tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate
- Product Name
- tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate
- CAS No.
- 1181816-12-5
- Chemical Name
- tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate
- Synonyms
- tert-butyl 6-oxo-2-azaspiro[3.4]octane-2-carboxylate;2-Boc-6-oxo-2-azaspiro[3....;6-oxo-2-azaspiro[3.3]hept...;2-Boc-6-oxo-2-azaspiro[3.3]heptane;6-oxo-2-azaspiro[3.3]heptane-2-carboxyL;tert-butyl 6-oxo-2-azaspiro[3.4]octane-2-ca;ert-Butyl6-oxo-2-azaspiro[3.3]heptane-2-carboxylate;Tert-butyl-6-oxo-2-azaspiro[3,3]heptane-2-carxylate;tert-Butyl 7-oxo-2-azaspiro[3.4]octane-2-carboxylate;tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate
- CBNumber
- CB02470890
- Molecular Formula
- C11H17NO3
- Formula Weight
- 211.26
- MOL File
- 1181816-12-5.mol
tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate Property
- Melting point:
- 114.5-116 °C
- Boiling point:
- 314.7±42.0 °C(Predicted)
- Density
- 1.16±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- -0.93±0.20(Predicted)
- form
- solid
- color
- Pale yellow
- InChI
- InChI=1S/C11H17NO3/c1-10(2,3)15-9(14)12-6-11(7-12)4-8(13)5-11/h4-7H2,1-3H3
- InChIKey
- HQHRAGXKFOTSQE-UHFFFAOYSA-N
- SMILES
- C1C2(CC(=O)C2)CN1C(OC(C)(C)C)=O
- CAS DataBase Reference
- 1181816-12-5
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
N-Bromosuccinimide Price
- Product number
- B809410
- Product name
- tert-Butyl6-Oxo-2-azaspiro[3.3]heptane-2-carboxylate
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- B809410
- Product name
- tert-Butyl6-Oxo-2-azaspiro[3.3]heptane-2-carboxylate
- Packaging
- 500mg
- Price
- $165
- Updated
- 2021/12/16
- Product number
- B809410
- Product name
- tert-Butyl6-Oxo-2-azaspiro[3.3]heptane-2-carboxylate
- Packaging
- 2.5g
- Price
- $605
- Updated
- 2021/12/16
- Product number
- OR308105
- Product name
- tert-Butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate
- Packaging
- 1g
- Price
- $141
- Updated
- 2021/12/16
- Product number
- 070594
- Product name
- 6-Oxo-2-azaspiro[3.3]heptane-2-carboxylicacid tert-butyl ester
- Purity
- 95%
- Packaging
- 250mg
- Price
- $457
- Updated
- 2021/12/16
tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate Chemical Properties,Usage,Production
Uses
tert-Butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate is a reagent used for the preparation of γ-butyrolactone derivative via Baeyer-Villiger monooxygenase (BVMO)-catalyzed oxidation.
Synthesis
A solution of crude tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate (1.00 g,4.69mmol, 1.00 equiv) in dichloromethane(20 mL) was treated with Dess-Martin periodinane(2.10g,4.95 mmol, 1.06 equiv) in two batches a few min apart at 0 °C. After 10 min, the ice bath wasremoved, and the reaction was monitored by TLC (50% ethyl acetate, PMA stain). After 30 min.the reaction was diluted with ethyl acetate and washed twice with satd sodium bicarbonate. Theorganic layer was dried over sodium sulfate, filtered, and concentrated. The crude product waspurified by flash chromatography (80g silica gel, 10 to 50% ethyl acetate/heptane; pure fractionswere identified by TLC with PMA stain; an unidentified impurity elutes slightly earlier than theproduct) to give tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate as a white solid (721 mg,73%). mp 114.5-116C.
tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate Suppliers
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- sales@apolloscientific.co.uk
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View Lastest Price from tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate manufacturers
- Product
- tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate 1181816-12-5
- Price
- US $100.00-1600.00/g
- Min. Order
- 5g
- Purity
- 99%
- Supply Ability
- 30
- Release date
- 2024-07-11
- Product
- tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate 1181816-12-5
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000 tons
- Release date
- 2020-04-27
- Product
- Tert-Butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate 1181816-12-5
- Price
- US $0.00/KG
- Min. Order
- 25KG
- Purity
- 95%
- Supply Ability
- Inquiry
- Release date
- 2022-09-20