2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE

Product Name: 2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE
CAS No.: 145100-51-2
Chemical Name: 2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE
Synonyms: Comins;N-(5-CHLORO-2-PYRIDYL)TRIFLIMIDE;N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-;N-(5-CHLORO-2-PYRIDYL)BIS(TRIFLUOROMETHANESULFONIMIDE);N,N-BIS(TRIFLUOROMETHYLSULFONYL)-5-CHLORO-2-PYRIDYLAMINE;2-[N,N-BIS(TRIFLUOROMETHYLSULPHONYL)AMINO]-5-CHLOROPYRIDINE;N-(5-Chloropyridin-2-yl)-1,1,1-trifluoro-N-(trifluoromethylsulfonyl)methanesulfonamide;Comins'reagent;Comins Triflating Reagent;N-(5-Chloropyridin-2-yl)triflimide
CBNumber: CB0248253
Molecular Formula: C7H3ClF6N2O4S2
Formula Weight: 392.68
MOL File: 145100-51-2.mol

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2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE Property

Melting point:: 45-47 °C(lit.)
Boiling point:: 77-90°C/0.2mmHg
Density: 1.892±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Benzene (Slightly)
form: Solid
pka: -7.71±0.10(Predicted)
color: yellow
Water Solubility: Reacts with water.
Sensitive: Moisture Sensitive
BRN: 5833971
Stability:: Moisture Sensitive, Unstable in DMSO Solution
InChI: InChI=1S/C7H3ClF6N2O4S2/c8-4-1-2-5(15-3-4)16(21(17,18)6(9,10)11)22(19,20)7(12,13)14/h1-3H
InChIKey: TUFGVZMNGTYAQD-UHFFFAOYSA-N
SMILES: C(F)(F)(F)S(N(C1=NC=C(Cl)C=C1)S(C(F)(F)F)(=O)=O)(=O)=O
CAS DataBase Reference: 145100-51-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
F: 9
Hazard Note: Irritant
HazardClass: AIR SENSITIVE, IRRITANT-HARMFUL, KEEP COLD
HS Code: 29350090
Storage Class: 11 - Combustible Solids
Hazard Classifications: Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 403644
Product name: N-(5-Chloro-2-pyridyl)bis(trifluoromethanesulfonimide)
Purity: 96%
Packaging: 1g
Price: $28.12
Updated: 2025/07/31

Sigma-Aldrich

Product number: 403644
Product name: N-(5-Chloro-2-pyridyl)bis(trifluoromethanesulfonimide)
Purity: 96%
Packaging: 5g
Price: $123.66
Updated: 2025/07/31

TCI Chemical

Product number: B1865
Product name: 2-[N,N-Bis(trifluoromethanesulfonyl)amino]-5-chloropyridine [Triflating Reagent]
Purity: >96.0%(GC)
Packaging: 5g
Price: $83
Updated: 2025/07/31

TCI Chemical

Product number: B1865
Product name: 2-[N,N-Bis(trifluoromethanesulfonyl)amino]-5-chloropyridine [Triflating Reagent]
Purity: >96.0%(GC)
Packaging: 25g
Price: $412
Updated: 2025/07/31

TRC

Product number: B585565
Product name: 2-[N,N-Bis(trifluoromethylsulfonyl)amino]-5-chloropyridine
Packaging: 5g
Price: $80
Updated: 2021/12/16

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2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE Chemical Properties,Usage,Production

Chemical Properties

White to pale yellow crystalline solid

Uses

2-[N,N-Bis(trifluoromethylsulfonyl)amino]-5-chloropyridine provides good yields of vinyl triflates from the corresponding ketone enolates or dienolates. It is used in the total synthesis of (-)-porantheridine and the trans decahydroquinoline alkaloid (+)-219A. It is also used as a reactant for Suzuki-Miyaura cross coupling, synthesis of nicotinic acetylcholine receptor-selective ligands, enantioselective desymmetrizing palladium catalyzed carbonylation reactions, synthesis of high affinity niacin receptor GPR109A agonists and in preparation of heteroaromatics.

Uses

Reactant for:
Suzuki-Miyaura cross coupling
Synthesis of nicotinic acetylcholine receptor-selective ligands
Enantioselective desymmetrizing palladium catalyzed carbonylation reactions
Synthesis of high affinity niacin receptor GPR109A agonists
Preparation of heteroaromatics

2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE Suppliers

Americas 1 Belgium 4 China 175 Europe 1 France 2 Germany 6 India 7 Japan 2 Switzerland 1 The Netherlands 1 United Kingdom 14 United States 36 Global 250

Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
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Jining Huanju Pharmaceutical Co., Ltd.

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J & K SCIENTIFIC LTD.

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Alfa Aesar

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TCI (Shanghai) Development Co., Ltd.

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Energy Chemical

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Wuhan Chemwish Technology Co., Ltd

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View Lastest Price from 2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE 145100-51-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-26

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE 145100-51-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2025-03-14

Zibo Hangyu Biotechnology Development Co., Ltd

Product: 2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE 145100-51-2
Price: US $50.00-500.00/kg
Min. Order: 10kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-10-31

145100-51-2, 2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINERelated Search:

Mesitylene-2-sulfonyl chloride 2-[N,N-BIS(TRIFLUOROMETHYLSULFONYL)AMINO]PYRIDINE 2-Amino-5-chloropyridine Trifluoromethanesulfonamide 2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE Trifluoromethanesulfonimide

Comins Reagent, N,N-Bis(trifluoromethylsulfonyl)-5-chloro-2-pyridylamine, 2-[N,N-Bis(trifluoromethylsulfonyl)amino]-5-chloropyridine

N-(5-CHLORO-2-PYRIDYL)BIS(TRILFUOROMETHANESULFONIMIDE)

N-(5-Chloropyridin-2-yl)-1,1,1-trifluoro-N-(trifluoromethylsulfonyl)methanesulfonamide

2-[N,N-Bis(trifluoromethanesulfonyl)amino]-5-chloropyridine ,98%

Comins Triflating Reagent

N-(5-Chloro-2-pyridyl)triflimide N-(5-Chloro-2-pyridyl)bis(trifluoromethanesulfonyl)imide Comins Triflating Reagent

N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-(trifluoroMethane)sulfonylMethanesulfonaMide

2-{Bis[(trifluoromethyl)sulphonyl]amino}-5-chloropyridine

N-(5-Chloropyridin-2-yl)triflimide

N-(5-CHLORO-2-PYRIDYL)BIS(TRIFLUOROMETHANESULFONIMIDE)

N-(5-CHLORO-2-PYRIDYL)TRIFLIMIDE

N,N-BIS(TRIFLUOROMETHYLSULFONYL)-5-CHLORO-2-PYRIDYLAMINE

2-[N,N-BIS(TRIFLUOROMETHYLSULPHONYL)AMINO]-5-CHLOROPYRIDINE

2-[N,N-BIS(TRIFLUOROMETHANESULPHONYL)AMINO]-5-CHLOROPYRIDINE

2-[N,N-BIS(TRIFLUOROMETHYLSULFONYL)AMINO]-5-CHLOROPYRIDINE

2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE

Bistrifluoromethylsulfonylaminochloropyridine

Comins

Comins'reagent

N-(5-chloropyridin-2-yl)trifluoro-N-(trifluoromethylsulfonyl)methanesulfonamide

n-(5-chloro-2-pyridyl)bis(trifluoromethanesulfonyl)imide

2-[N,N-bis(trifluoromethylsulphony)amino]-5-chloropyridine

2-[N,N-BIS(TRIFLUROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE

N-(5-chloro-2-pyridyl)bis(trifluromethanesulfonimide

2-[N,N-Bis(trifluoromethanesulfonyl)amino]-5-chloropyridine [Triflating Reagent]

2-N,N-Bis(trifluoromethanesulfonyl)aminoü-5-chloropyridine, 99%

2-[N,N-Bis(trifluoromethanesulfonyl)amino]-5-chloropyridine[TriflatingReagent]&gt

Methanesulfonamide, N-(5-chloro-2-pyridinyl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulfonyl]-

2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE ISO 9001：2015 REACH

N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-

N-(5-chloro-2-pyridyl)-1,1,1-trifluoro-N-(trifluoromethylsulfonyl)methanesulfonamide

<i>N</i>-(5-Chloro-2-pyridyl)bis(trifluoromethanesulfonimide)

145100-51-2

C7Cl1F6H3N2O4S2

C7H3ClF6N2O4S2

Halopyridines

Chloropyridines

Building Blocks

C7 and C8

Heterocyclic Building Blocks

Pyridines

Chloropyridines

Halopyridines