ChemicalBook > CAS DataBase List > 2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE

2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE

Product Name
2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE
CAS No.
145100-51-2
Chemical Name
2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE
Synonyms
Comins;N-(5-CHLORO-2-PYRIDYL)TRIFLIMIDE;N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-;N-(5-CHLORO-2-PYRIDYL)BIS(TRIFLUOROMETHANESULFONIMIDE);N,N-BIS(TRIFLUOROMETHYLSULFONYL)-5-CHLORO-2-PYRIDYLAMINE;2-[N,N-BIS(TRIFLUOROMETHYLSULPHONYL)AMINO]-5-CHLOROPYRIDINE;N-(5-Chloropyridin-2-yl)-1,1,1-trifluoro-N-(trifluoromethylsulfonyl)methanesulfonamide;Comins'reagent;Comins Triflating Reagent;N-(5-Chloropyridin-2-yl)triflimide
CBNumber
CB0248253
Molecular Formula
C7H3ClF6N2O4S2
Formula Weight
392.68
MOL File
145100-51-2.mol
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2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE Property

Melting point:
45-47 °C(lit.)
Boiling point:
77-90°C/0.2mmHg
Density 
1.892±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Benzene (Slightly)
form 
Solid
pka
-7.71±0.10(Predicted)
color 
yellow
Water Solubility 
Reacts with water.
Sensitive 
Moisture Sensitive
BRN 
5833971
Stability:
Moisture Sensitive, Unstable in DMSO Solution
InChIKey
TUFGVZMNGTYAQD-UHFFFAOYSA-N
CAS DataBase Reference
145100-51-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
F 
9
Hazard Note 
Irritant
HazardClass 
AIR SENSITIVE, IRRITANT-HARMFUL, KEEP COLD
HS Code 
29350090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
403644
Product name
N-(5-Chloro-2-pyridyl)bis(trifluoromethanesulfonimide)
Purity
96%
Packaging
1g
Price
$28.7
Updated
2024/03/01
Sigma-Aldrich
Product number
403644
Product name
N-(5-Chloro-2-pyridyl)bis(trifluoromethanesulfonimide)
Purity
96%
Packaging
5g
Price
$127
Updated
2024/03/01
TCI Chemical
Product number
B1865
Product name
2-[N,N-Bis(trifluoromethanesulfonyl)amino]-5-chloropyridine [Triflating Reagent]
Purity
>96.0%(GC)
Packaging
5g
Price
$83
Updated
2024/03/01
TCI Chemical
Product number
B1865
Product name
2-[N,N-Bis(trifluoromethanesulfonyl)amino]-5-chloropyridine [Triflating Reagent]
Purity
>96.0%(GC)
Packaging
25g
Price
$412
Updated
2024/03/01
Alfa Aesar
Product number
L16929
Product name
2-[N,N-Bis(trifluoromethylsulfonyl)amino]-5-chloropyridine, 99%
Packaging
1g
Price
$37.65
Updated
2024/03/01
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2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE Chemical Properties,Usage,Production

Chemical Properties

White to pale yellow crystalline solid

Uses

2-[N,N-Bis(trifluoromethylsulfonyl)amino]-5-chloropyridine provides good yields of vinyl triflates from the corresponding ketone enolates or dienolates. It is used in the total synthesis of (-)-porantheridine and the trans decahydroquinoline alkaloid (+)-219A. It is also used as a reactant for Suzuki-Miyaura cross coupling, synthesis of nicotinic acetylcholine receptor-selective ligands, enantioselective desymmetrizing palladium catalyzed carbonylation reactions, synthesis of high affinity niacin receptor GPR109A agonists and in preparation of heteroaromatics.

Uses

Reactant for:
Suzuki-Miyaura cross coupling
Synthesis of nicotinic acetylcholine receptor-selective ligands
Enantioselective desymmetrizing palladium catalyzed carbonylation reactions
Synthesis of high affinity niacin receptor GPR109A agonists
Preparation of heteroaromatics

2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE Suppliers

Americas 1 Belgium 4 China 172 Europe 1 France 2 Germany 6 India 8 Japan 2 Switzerland 1 The Netherlands 1 United Kingdom 14 United States 36 Global 248
NovoChemy Ltd.
Tel
021-31261262/ 49 (0)17662837245
Fax
(0)21-33250524
Email
sales@novochemy.com
Country
Germany
ProdList
6328
Advantage
58
Alfa Aesar, Thermo Fisher Scientific
Tel
--
Fax
--
Email
es@alfa.com
Country
Germany
ProdList
5123
Advantage
58
CHEMOS GmbH & Co. KG
Tel
--
Fax
--
Email
chemos@chemos.de
Country
Germany
ProdList
6727
Advantage
58
Central Glass Germany GmbH
Tel
--
Fax
--
Email
info@cg-germany.com
Country
Germany
ProdList
98
Advantage
58
ABCR GmbH & CO. KG
Tel
--
Fax
--
Email
info@abcr.de
Country
Germany
ProdList
6831
Advantage
75
Service Chemical Inc.
Tel
--
Fax
--
Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71
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View Lastest Price from 2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE 145100-51-2
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2024-12-11
Zibo Hangyu Biotechnology Development Co., Ltd
Product
2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE 145100-51-2
Price
US $50.00-500.00/kg
Min. Order
10kg
Purity
0.99
Supply Ability
20tons
Release date
2023-10-31
Hebei Mojin Biotechnology Co., Ltd
Product
2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE 145100-51-2
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-08-17

145100-51-2, 2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINERelated Search:

Mesitylene-2-sulfonyl chloride 2-[N,N-BIS(TRIFLUOROMETHYLSULFONYL)AMINO]PYRIDINE 2-Amino-5-chloropyridine Trifluoromethanesulfonamide 2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE Trifluoromethanesulfonimide

  • Comins Reagent, N,N-Bis(trifluoromethylsulfonyl)-5-chloro-2-pyridylamine, 2-[N,N-Bis(trifluoromethylsulfonyl)amino]-5-chloropyridine
  • N-(5-CHLORO-2-PYRIDYL)BIS(TRILFUOROMETHANESULFONIMIDE)
  • N-(5-Chloropyridin-2-yl)-1,1,1-trifluoro-N-(trifluoromethylsulfonyl)methanesulfonamide
  • 2-[N,N-Bis(trifluoromethanesulfonyl)amino]-5-chloropyridine ,98%
  • Comins Triflating Reagent
  • N-(5-Chloro-2-pyridyl)triflimide N-(5-Chloro-2-pyridyl)bis(trifluoromethanesulfonyl)imide Comins Triflating Reagent
  • N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-(trifluoroMethane)sulfonylMethanesulfonaMide
  • 2-{Bis[(trifluoromethyl)sulphonyl]amino}-5-chloropyridine
  • N-(5-Chloropyridin-2-yl)triflimide
  • N-(5-CHLORO-2-PYRIDYL)BIS(TRIFLUOROMETHANESULFONIMIDE)
  • N-(5-CHLORO-2-PYRIDYL)TRIFLIMIDE
  • N,N-BIS(TRIFLUOROMETHYLSULFONYL)-5-CHLORO-2-PYRIDYLAMINE
  • 2-[N,N-BIS(TRIFLUOROMETHYLSULPHONYL)AMINO]-5-CHLOROPYRIDINE
  • 2-[N,N-BIS(TRIFLUOROMETHANESULPHONYL)AMINO]-5-CHLOROPYRIDINE
  • 2-[N,N-BIS(TRIFLUOROMETHYLSULFONYL)AMINO]-5-CHLOROPYRIDINE
  • 2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE
  • Bistrifluoromethylsulfonylaminochloropyridine
  • Comins
  • Comins'reagent
  • N-(5-chloropyridin-2-yl)trifluoro-N-(trifluoromethylsulfonyl)methanesulfonamide
  • n-(5-chloro-2-pyridyl)bis(trifluoromethanesulfonyl)imide
  • 2-[N,N-bis(trifluoromethylsulphony)amino]-5-chloropyridine
  • 2-[N,N-BIS(TRIFLUROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE
  • N-(5-chloro-2-pyridyl)bis(trifluromethanesulfonimide
  • 2-[N,N-Bis(trifluoromethanesulfonyl)amino]-5-chloropyridine [Triflating Reagent]
  • 2-N,N-Bis(trifluoromethanesulfonyl)aminoü-5-chloropyridine, 99%
  • 2-[N,N-Bis(trifluoromethanesulfonyl)amino]-5-chloropyridine[TriflatingReagent]&gt
  • Methanesulfonamide, N-(5-chloro-2-pyridinyl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulfonyl]-
  • 2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE ISO 9001：2015 REACH
  • N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-
  • N-(5-chloro-2-pyridyl)-1,1,1-trifluoro-N-(trifluoromethylsulfonyl)methanesulfonamide
  • 145100-51-2
  • C7Cl1F6H3N2O4S2
  • C7H3ClF6N2O4S2
  • Halopyridines
  • Chloropyridines
  • Building Blocks
  • C7 and C8
  • Heterocyclic Building Blocks
  • Pyridines
  • Chloropyridines
  • Halopyridines