ChemicalBook > CAS DataBase List > 2-[2-(2-Azidoethoxy)ethoxy]ethanamine

2-[2-(2-Azidoethoxy)ethoxy]ethanamine

Product Name
2-[2-(2-Azidoethoxy)ethoxy]ethanamine
CAS No.
166388-57-4
Chemical Name
2-[2-(2-Azidoethoxy)ethoxy]ethanamine
Synonyms
N3-PEG2-NH2;Azido-PEG2-NH2;H2N-C2-PEG2-N3;Azide-PEG3-Amine;Azido-PEG2-Amine;N3-PEG2-CH2CH2NH2;Azido-PEG2-C2-amine;Azido-PEG2-CH2CH2NH2;Azido-PEG2-CH2CH2-Amine;Amino-PEG2-azide,NH2-PEG2-N3
CBNumber
CB02484811
Molecular Formula
C6H14N4O2
Formula Weight
174.2
MOL File
166388-57-4.mol
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2-[2-(2-Azidoethoxy)ethoxy]ethanamine Property

solubility 
Soluble in Water, DMSO, DMF, DCM
form 
Liquid
color 
Colorless to light yellow
CAS DataBase Reference
166388-57-4
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Safety

HS Code 
2929900090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
B407568
Product name
2-[2-(2-Azidoethoxy)ethoxy]ethanamine
Packaging
1g
Price
$185
Updated
2021/12/16
Biosynth Carbosynth
Product number
FP73033
Product name
Azido-PEG2-amine
Packaging
1g
Price
$200
Updated
2021/12/16
BroadPharm
Product number
BP-20692
Product name
Azido-PEG2-amine
Purity
98%
Packaging
5G
Price
$295
Updated
2021/12/16
Biosynth Carbosynth
Product number
FP73033
Product name
Azido-PEG2-amine
Packaging
2g
Price
$300
Updated
2021/12/16
ChemScene
Product number
CS-0114352
Product name
Azido-PEG2-C2-amine
Packaging
5g
Price
$395
Updated
2021/12/16
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2-[2-(2-Azidoethoxy)ethoxy]ethanamine Chemical Properties,Usage,Production

Description

Azido-PEG2-amine is a bifunctional crosslinker containing an amino and an azide group. The amino group is reactive with carboxylic acids, activated NHS esters,. The azide(N3) group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage.

Synthesis

2-[2-(2-Hydroxyethoxy)ethoxy]ethyl chloride (15 g, 88.9 mmol), NaI(4.06 g, 27.1 mmol), and NaN3 (45.3 mg, 697 mmol) were dissolved in distilled water (90 mL), and the solution was stirred for 48 h at 50 °C. The reaction mixture extracted with ethyl acetate for three times. The organic layer was dried over Na2SO4 , and evaporated to collect 2-[2-(2-azidoethoxy)ethoxy]ethanol (14.0 g, 90.1%) as a yellow oil.To the solution 2-[2-(2-azidoethoxy)ethoxy]ethanol (8 g, 45.7 mmol) in THF (22.4 mL), 6 M NaOH(20.8 mL) and TsCl (13.1 g, 68.6 mmol) were added at 0 °C. The reaction mixture was stirred for 1 h at room temperature under nitrogen atmosphere. The solution was then extracted with diethyl ether four times, and the organic layer was washed with 1 M NaOH. After evaporation of the organic layer,2-[2-(2-azidoethoxy)ethoxy]ethyl tosylate (16.8 g, 98.6%) was obtained as a yellow oil.Finally, ammonia solution (28%, 14.8 mL, 365 mol) was added to the 2-[2-(2-azidoethoxy)ethoxy]-ethyl tosylate (8 g, 24.3 mmol) dissolved in THF (95.9 mL), and reaction mixture was stirred for 96 h at 40 °C. After the reaction, distilled water (50 mL) was added to the solution. The mixture was washed with diethyl ether and then extracted with dichloromethane. The organic layer was dried over NaSO4 and evaporated to obtain 2-[2-(2-azidoethoxy)ethoxy]ethanamine (2.49 g, 58.8%) as a yellow oil.

2-[2-(2-Azidoethoxy)ethoxy]ethanamine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-[2-(2-Azidoethoxy)ethoxy]ethanamine Suppliers

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ChemPep, Inc.
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View Lastest Price from 2-[2-(2-Azidoethoxy)ethoxy]ethanamine manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
azido-PEG2-amine 166388-57-4
Price
US $0.00/g
Min. Order
10g
Purity
>98.00%
Supply Ability
10g
Release date
2024-03-23

166388-57-4, 2-[2-(2-Azidoethoxy)ethoxy]ethanamineRelated Search:

2-(2-Azidoethoxy)ethanol Biotin-PEG3-propionic acid HS-PEG4-tBu 5,8,11,14-Tetraoxa-2-azahexadecanoic acid,16-amino-,1,1-dimethyl ester 3,6,9,12-tetraoxatridecylamine PENTAETHYLENE GLYCOL H2N-PEG4-tBu 1H-Thieno[3,4-d]imidazole-4-pentanamide,N-(14-amino-3,6,9,12-tetraoxatetradec-1-yl)hexahydro-2-oxo-,(3aS,4S,6aR)- Decaethylene glycol O-(2-AMINOETHYL)-O-(2-(BOC-AMINO)ETHYL)OCTAETHYLENE GLYCOL 6-Maleimidocaproic acid 2-[2-(2-methoxyethoxy)ethoxy]-ethanethiol 2,5,8,11,14,17,20,23-Octaoxapentacosane-25-thiol HEPTAETHYLENE GLYCOL FMOC-15-AMINO-4,7,10,13-TETRAOXAPENTADECANOIC ACID MPEG7-CH2CH2COOH (R)-N-(3,6,9,12-Tetraoxatridecyl)-alpha-lipoamide Z-15-aMino-4,7,10,13-tetraoxapentadecacanoic acid

  • N3-PEG2-CH2CH2NH2
  • Azido-PEG2-Amine
  • 2-[2-(2-Azidoethoxy)ethoxy]ethanamine
  • N3-PEG2-NH2
  • Azido-PEG2-NH2
  • 2-[2-(2-Azido-ethoxy)-ethoxy]-ethylamine
  • Azido-PEG2-C2-amine
  • Amino-PEG2-azide,NH2-PEG2-N3
  • Azide-PEG3-Amine
  • Ethanamine, 2-[2-(2-azidoethoxy)ethoxy]-
  • N3-PEG2-CH2CH2NH2/Ethanamine, 2-[2-(2-azidoethoxy)ethoxy]-
  • H2N-C2-PEG2-N3
  • Azido-PEG2-CH2CH2NH2
  • Azido-PEG2-CH2CH2-Amine
  • 166388-57-4
  • 1660388-57-4
  • peg