tert-Butyl[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin -2-yl]carbamate

Product Name: tert-Butyl[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin -2-yl]carbamate
CAS No.: 1095708-32-9
Chemical Name: tert-Butyl[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin -2-yl]carbamate
Synonyms: Boc-2-AMinopyridine-4-boronic acid pinacol ester;2-boc-aminopyridine-4-borate frequency alcohol ester;2-(tert-Butoxycarbonylamino)pyridine-4-boronic acid pinacol ...;2-(tert-ButoxycarbonylaMino)pyridine-4-boronic acid pinacol ester;(2-((TERT-BUTOXYCARBONYL)AMINO)PYRIDIN-4-YL)BORONIC ACID PINACOL ESTER;tert-butyl N-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]carbamate;2-(tert-Butoxycarbonylamino)pyridine-4-boronic acid pinacol ester - [A12056];N-tert-butyl-N-[3-(tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]carbaMate;ert-Butyl[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin -2-yl]carbamate;tert-Butyl[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin -2-yl]carbamate
CBNumber: CB02500414
Molecular Formula: C16H25BN2O4
Formula Weight: 320.19
MOL File: 1095708-32-9.mol

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tert-Butyl[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin -2-yl]carbamate Property

Boiling point:: 400.7±30.0 °C(Predicted)
Density: 1.10
storage temp.: Sealed in dry,Store in freezer, under -20°C
pka: 12.66±0.70(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: B621203
Product name: Boc-2-aminopyridine-4-boronicAcidPinacolEster
Packaging: 100mg
Price: $85
Updated: 2021/12/16

TRC

Product number: B621203
Product name: Boc-2-aminopyridine-4-boronicAcidPinacolEster
Packaging: 25mg
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 093840
Product name: tert-Butyl (4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)carbamate
Purity: 95+%
Packaging: 250mg
Price: $515
Updated: 2021/12/16

AK Scientific

Product number: Y7027
Product name: tert-Butyl4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-ylcarbamate
Packaging: 5g
Price: $736
Updated: 2021/12/16

Synthonix

Product number: A12056
Product name: 2-(tert-Butoxycarbonylamino)pyridine-4-boronicacidpinacolester
Purity: 97.0%
Packaging: 10g
Price: $930
Updated: 2021/12/16

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tert-Butyl[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin -2-yl]carbamate Chemical Properties,Usage,Production

Synthesis

207799-10-8

73183-34-3

1095708-32-9

A reaction mixture was prepared in dimethyl sulfoxide (8 mL) with 2-Boc amine-4-bromopyridine (0.494 g, 1.81 mmol), pinacol ester of bisboronic acid (1.4 g, 5.51 mmol) and potassium acetate (0.535 g, 5.45 mmol). The mixture was purged with nitrogen for 10 min to deoxygenate. Subsequently, [1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloride (0.150 g, 0.184 mmol) was added and again purged with nitrogen for 5 min. Under nitrogen protection, the reaction mixture was heated to 85 °C and stirred for 1 hour. Upon completion of the reaction, the mixture was diluted with ethyl acetate (15 mL) and washed with 0.2 M aqueous hydrochloric acid (10 mL). Note that some of the product may be present in the aqueous layer. Carefully adjust the pH of the aqueous layer to about 6 with saturated aqueous sodium carbonate, and then extract the product from the aqueous layer with ethyl acetate (10 mL). The organic layers were combined, dried over anhydrous sodium sulfate, filtered and concentrated in vacuum to afford 2-(Boc-amino)pyridine-4-boronic acid pinacol ester as a white solid (0.44 g, 76% yield). The product was characterized by 1H NMR (DMSO-d6) and LCMS: 1H NMR (DMSO-d6) δ 1.29 (s, 12H), 1.45 (s, 9H), 7.15-7.17 (d, 1H), 8.07 (s, 1H), 8.24-8.25 (d, 1H), 9.77 (s, 1H); LCMS Rt = 0.68 min, MS m/z 183.1 [M+H]+.

References

[1] Journal of Medicinal Chemistry, 2017, vol. 60, # 13, p. 5613 - 5637
[2] Patent: WO2012/4714, 2012, A2. Location in patent: Page/Page column 62
[3] Patent: US2014/194443, 2014, A1. Location in patent: Paragraph 0543-0545
[4] Patent: WO2014/108337, 2014, A1. Location in patent: Page/Page column 69; 70
[5] Patent: US2010/179154, 2010, A1. Location in patent: Page/Page column 29

tert-Butyl[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin -2-yl]carbamate Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-Butyl[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin -2-yl]carbamate Suppliers

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View Lastest Price from tert-Butyl[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin -2-yl]carbamate manufacturers

Career Henan Chemical Co

Product: tert-butyl N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]carbamate 1095708-32-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98% HPLC
Supply Ability: 10 tons/month
Release date: 2020-01-09

1095708-32-9, tert-Butyl[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin -2-yl]carbamate Related Search:

1-(BOC-AMINOMETHYL)-3,3-DFLUOROCYCLOBUTANE-1-METHAMINE 3,5-DIMETHYLPYRIDINE-4-BORONIC ACID PINACOL ESTER 4-Isoquinolineboronic acid 4-CHLORO-(N-BOC)ANILINE 97 (4-Bromo-2-fluoro-5-methyl-phenyl)-carbamic acid tert-butyl ester N-BOC-4-broMo-3-Methylaniline 2-BOC-AMINO-4-BROMOTOLUENE (6-BROMO-2-PYRIDINYL)-CARBAMIC ACID,1,1-DIMETHYLETHYL ESTER (5-BROMO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER CARBAMIC ACID, (5-BROMO-4-METHYL-2-PYRIDINYL)-,1,1-DIMETHYLETHYL ESTER (2-Bromo-5-methyl-phenyl)-carbamic acid tert-butyl ester tert-butyl 4-Methyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-ylcarbaMate Tert-butyl (4-bromo-2,3-dimethylphenyl)carbamate tert-butyl N-[3-(4-amino-1H-pyrazol-1-yl)propyl]carbamate N-(3-Iodo-5-methylpyridin-2-yl)pivalamide tert-Butyl (2,6-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)biscarbamate Carbamic acid, N-(4-bromo-2,5-difluorophenyl)-, 1,1-dimethylethyl ester Carbamic acid, N-(4-bromo-2,6-difluorophenyl)-, 1,1-dimethylethyl ester

tert-Butyl[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin -2-yl]carbamate

N-tert-butyl-N-[3-(tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]carbaMate

2-(tert-ButoxycarbonylaMino)pyridine-4-boronic acid pinacol ester

Boc-2-AMinopyridine-4-boronic acid pinacol ester

tert-butyl N-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]carbamate

[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-2-yl]-carbamic acid tert-butyl ester 97%

(2-((TERT-BUTOXYCARBONYL)AMINO)PYRIDIN-4-YL)BORONIC ACID PINACOL ESTER

tert-butyl (4-(hydroxy((3-hydroxy-2,3-dimethylbutan-2-yl)oxy)boranyl)pyridin-2-yl)carbamate

tert-butyl N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]carbamate

Carbamic acid, N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]-, 1,1-dimethylethyl ester

2-(tert-Butoxycarbonylamino)pyridine-4-boronic acid pinacol ...

1,1-Dimethylethyl N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]carbamate

2-boc-aminopyridine-4-borate frequency alcohol ester

ert-Butyl[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin -2-yl]carbamate

2-(tert-Butoxycarbonylamino)pyridine-4-boronic acid pinacol ester - [A12056]

1095708-32-9