LDN-193189 HCl
- Product Name
- LDN-193189 HCl
- CAS No.
- 1062368-62-0
- Chemical Name
- LDN-193189 HCl
- Synonyms
- CS-1451;LDN-193189 HCl;LDN-193189 4HCl;LDN-193189 HCl USP/EP/BP;LDN193189 (Hydrochloride);LDN-193189 HCL;LDN 193189 HCL;4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyriMidin-3-yl)quinoline HCl;LDN-193189 HCL;LDN 193189 HCL;LDN 193189 HYDROCHLORIDE;LDN-193189 HYDROCHLORIDE;LDN193189 hydrochloride, 98%, a selective BMP type I receptor kinases inhibitor;4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline hydrochloride
- CBNumber
- CB02517951
- Molecular Formula
- C25H23ClN6
- Formula Weight
- 442.94332
- MOL File
- 1062368-62-0.mol
LDN-193189 HCl Property
- Melting point:
- >240°C (dec.)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- Methanol (Slightly), DMSO (Very Slightly, Heated)
- form
- Solid
- color
- Dark Orange
- CAS DataBase Reference
- 1062368-62-0
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 19396
- Product name
- LDN-193189 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $25
- Updated
- 2021/12/16
- Product number
- 19396
- Product name
- LDN-193189 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 19396
- Product name
- LDN-193189 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $138
- Updated
- 2021/12/16
- Product number
- 19396
- Product name
- LDN-193189 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $300
- Updated
- 2021/12/16
- Product number
- P480133
- Product name
- LDN193189 hydrochloride
- Packaging
- 10mg
- Price
- $195
- Updated
- 2021/12/16
LDN-193189 HCl Chemical Properties,Usage,Production
Uses
4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline Hydrochoride is a selective inhibitor of bone morphogenetic protein (BMP) pathway, useful in the treatment of diseases.
Uses
LDN-193189 HCl has been used to inhibit BMP type I receptor activity to study the pathogenesis of fibrodysplasia ossificans progressive, a congenital hyperossification disorder, and to examine the role of osteogenesis in prostate tumor metastases in bone.
Biological Activity
ldn193189 is a selective transcriptional activity morphogenetic protein (bmp) type i receptors inhibitor. it inhibits activin receptor-like kinase-2 (alk2) and alk3 with ic50 values of 5 nm and 30 nm, respectively [1].ldn193189 has been showed to inhibit bmp induced phosphorylation of smad signaling (smad1/5/8) and non-smad signaling including p38 and akt in c2c12 cells [2].pharmacological inhibition of bmp by ldn193189 has shown to prevent down-regulation of e-cadherin in response to bmp2 both in bronchial epithelial (beas2b) cells and in c57bl/6 mice. ldn193189 also inhibits the bmp-induced reduction of epithelial permeability at cellular level [3].
References
[1] yu pb, deng dy, lai cs, hong cc, cuny gd, bouxsein ml, hong dw, mcmanus pm, katagiri t, sachidanandan c, kamiya n, fukuda t, mishina y, peterson rt, bloch kd. bmp type i receptor inhibition reduces heterotopic [corrected] ossification. nat med. 2008 dec;14(12):1363-9.
[2] boergermann jh1, kopf j, yu pb, knaus p. dorsomorphin and ldn-193189 inhibit bmp-mediated smad, p38 and akt signalling in c2c12 cells. int j biochem cell biol. 2010 nov;42(11):1802-7.
[3] helbing t1, herold em, hornstein a, wintrich s, heinke j, grundmann s, patterson c, bode c, moser m. inhibition of bmp activity protects epithelial barrier function in lung injury. j pathol. 2013 sep;231(1):105-16. doi: 10.1002/path.4215. epub 2013 jul 10.
LDN-193189 HCl Preparation Products And Raw materials
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View Lastest Price from LDN-193189 HCl manufacturers
- Product
- LDN-193189 HCl 1062368-62-0
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99.99%
- Supply Ability
- 200kg
- Release date
- 2019-12-23