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LDN-193189 HCl

Product Name
LDN-193189 HCl
CAS No.
1062368-62-0
Chemical Name
LDN-193189 HCl
Synonyms
CS-1451;LDN-193189 HCl;LDN-193189 4HCl;LDN-193189 HCl USP/EP/BP;LDN193189 (Hydrochloride);LDN-193189 HCL;LDN 193189 HCL;4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyriMidin-3-yl)quinoline HCl;LDN-193189 HCL;LDN 193189 HCL;LDN 193189 HYDROCHLORIDE;LDN-193189 HYDROCHLORIDE;LDN193189 hydrochloride, 98%, a selective BMP type I receptor kinases inhibitor;4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline hydrochloride
CBNumber
CB02517951
Molecular Formula
C25H23ClN6
Formula Weight
442.94332
MOL File
1062368-62-0.mol
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LDN-193189 HCl Property

Melting point:
>240°C (dec.)
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
Methanol (Slightly), DMSO (Very Slightly, Heated)
form 
Solid
color 
Dark Orange
CAS DataBase Reference
1062368-62-0
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
19396
Product name
LDN-193189 (hydrochloride)
Purity
≥98%
Packaging
1mg
Price
$25
Updated
2021/12/16
Cayman Chemical
Product number
19396
Product name
LDN-193189 (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$75
Updated
2021/12/16
Cayman Chemical
Product number
19396
Product name
LDN-193189 (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$138
Updated
2021/12/16
Cayman Chemical
Product number
19396
Product name
LDN-193189 (hydrochloride)
Purity
≥98%
Packaging
25mg
Price
$300
Updated
2021/12/16
TRC
Product number
P480133
Product name
LDN193189 hydrochloride
Packaging
10mg
Price
$195
Updated
2021/12/16
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LDN-193189 HCl Chemical Properties,Usage,Production

Uses

4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline Hydrochoride is a selective inhibitor of bone morphogenetic protein (BMP) pathway, useful in the treatment of diseases.

Uses

LDN-193189 HCl has been used to inhibit BMP type I receptor activity to study the pathogenesis of fibrodysplasia ossificans progressive, a congenital hyperossification disorder, and to examine the role of osteogenesis in prostate tumor metastases in bone.

Biological Activity

ldn193189 is a selective transcriptional activity morphogenetic protein (bmp) type i receptors inhibitor. it inhibits activin receptor-like kinase-2 (alk2) and alk3 with ic50 values of 5 nm and 30 nm, respectively [1].ldn193189 has been showed to inhibit bmp induced phosphorylation of smad signaling (smad1/5/8) and non-smad signaling including p38 and akt in c2c12 cells [2].pharmacological inhibition of bmp by ldn193189 has shown to prevent down-regulation of e-cadherin in response to bmp2 both in bronchial epithelial (beas2b) cells and in c57bl/6 mice. ldn193189 also inhibits the bmp-induced reduction of epithelial permeability at cellular level [3].

References

[1] yu pb, deng dy, lai cs, hong cc, cuny gd, bouxsein ml, hong dw, mcmanus pm, katagiri t, sachidanandan c, kamiya n, fukuda t, mishina y, peterson rt, bloch kd. bmp type i receptor inhibition reduces heterotopic [corrected] ossification. nat med. 2008 dec;14(12):1363-9.
[2] boergermann jh1, kopf j, yu pb, knaus p. dorsomorphin and ldn-193189 inhibit bmp-mediated smad, p38 and akt signalling in c2c12 cells. int j biochem cell biol. 2010 nov;42(11):1802-7.
[3] helbing t1, herold em, hornstein a, wintrich s, heinke j, grundmann s, patterson c, bode c, moser m. inhibition of bmp activity protects epithelial barrier function in lung injury. j pathol. 2013 sep;231(1):105-16. doi: 10.1002/path.4215. epub 2013 jul 10.

LDN-193189 HCl Preparation Products And Raw materials

Raw materials

Preparation Products

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LDN-193189 HCl Suppliers

China 83 India 1 The Netherlands 1 United States 13 Global 98
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
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View Lastest Price from LDN-193189 HCl manufacturers

Career Henan Chemical Co
Product
LDN-193189 HCl 1062368-62-0
Price
US $1.00/g
Min. Order
1g
Purity
99.99%
Supply Ability
200kg
Release date
2019-12-23

1062368-62-0, LDN-193189 HClRelated Search:

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  • 4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline hydrochloride
  • 4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyriMidin-3-yl)quinoline HCl
  • LDN193189 (Hydrochloride)
  • 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline hydrochloride (1:1)
  • LDN-193189 HCl
  • LDN193189 hydrochloride, 98%, a selective BMP type I receptor kinases inhibitor
  • LDN-193189 HCL;LDN 193189 HCL;LDN 193189 HYDROCHLORIDE;LDN-193189 HYDROCHLORIDE
  • LDN-193189 HCL;LDN 193189 HCL
  • CS-1451
  • LDN-193189 HCl USP/EP/BP
  • LDN-193189 4HCl
  • 1062368-62-0
  • C25H26Cl4N6
  • C25H22N6HCl
  • C25H22N6ClH
  • Inhibitors