ChemicalBook > CAS DataBase List > (R)-3-Methylmorpholine hydrochloride

(R)-3-Methylmorpholine hydrochloride

Product Name
(R)-3-Methylmorpholine hydrochloride
CAS No.
953780-78-4
Chemical Name
(R)-3-Methylmorpholine hydrochloride
Synonyms
(R)-3-MethylMorpholine HCl;(3R)-3-Methylmorpholine HCl;(R)-3-Methylmorpholine chloride;(R)-3-Methylmorpholine hydrochloride;(3R)-3-Methylmorpholine hydrochloride;O-Benzyl-L-Threoninebenzyleser oxalate;(3R)-3-Methylmorpholine hydrochloride 98%;(R)-3-Methylmorpholine Hydrochloride;Morpholine, 3-methyl-, hydrochloride, (3R)-;(3R)-3-methyl-Morpholine hydrochloride (1:1)
CBNumber
CB02520102
Molecular Formula
C5H12ClNO
Formula Weight
137.61
MOL File
953780-78-4.mol
More
Less

(R)-3-Methylmorpholine hydrochloride Property

Melting point:
123.0 to 127.0 °C
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
powder to crystal
color 
White to Orange to Green
More
Less

Safety

HS Code 
2934999090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

More
Less

N-Bromosuccinimide Price

TCI Chemical
Product number
M2847
Product name
(R)-3-Methylmorpholine Hydrochloride
Purity
>98.0%(T)
Packaging
200mg
Price
$47
Updated
2025/07/31
TCI Chemical
Product number
M2847
Product name
(R)-3-Methylmorpholine Hydrochloride
Purity
>98.0%(T)
Packaging
1g
Price
$138
Updated
2025/07/31
SynQuest Laboratories
Product number
4H56-5-CX
Product name
(R)-3-Methylmorpholine hydrochloride
Purity
98%
Packaging
250mg
Price
$70
Updated
2021/12/16
AK Scientific
Product number
X4857
Product name
(3R)-3-methylmorpholinehydrochloride
Packaging
1g
Price
$89
Updated
2021/12/16
Activate Scientific
Product number
AS12233-B
Product name
(R)-3-Methyl-morpholine HCl
Purity
95% ee
Packaging
1g
Price
$49
Updated
2021/12/16
More
Less

(R)-3-Methylmorpholine hydrochloride Chemical Properties,Usage,Production

Uses

(3R)-3-Methylmorpholine Hydrochloride is used in the discovery studies of novel 2-(alkylmorpholin-4-yl)-6-(3-fluoropyridin-4-yl)-pyrimidin-4(3H)-ones as orally active GSK-3β inhibitors for Alzheimer''s disease

Synthesis

954133-47-2

953780-78-4

General procedure for the synthesis of (R)-3-methylmorpholine hydrochloride from the compound (CAS: 954133-47-2): to a solution of (5R)-4-(4-methoxybenzyl)-5-methylmorpholine (17.8 g, 80.3 mmol) in 1,2-dichloroethane (180 mL) was added 1-chloroethyl chloroformate (46 g, 322 mmol). The reaction mixture was stirred at 80 °C for 6 hours. Upon completion of the reaction, the solvent was removed by evaporation under reduced pressure. The residue was dissolved in methanol (180 mL) and stirred at 80 °C for 1 hour. The solvent was again removed by evaporation under reduced pressure and the residue was washed with ethyl acetate and dried to give (3R)-3-methylmorpholine hydrochloride (8.2 g, 59.6 mmol, 74% yield) as white crystals.

References

[1] Patent: WO2007/119463, 2007, A1. Location in patent: Page/Page column 197; 198
[2] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 5, p. 1086 - 1091

(R)-3-Methylmorpholine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

(R)-3-Methylmorpholine hydrochloride Suppliers

Americas 1 China 102 Europe 1 India 5 Japan 1 United Kingdom 1 United States 5 Global 116
TCI AMERICA
Tel
800-4238616
Fax
+1-888-520-1075 / +1-503-283-1987
Email
sales@tciamerica.com
Country
Americas
ProdList
23653
Advantage
75
More
Less

View Lastest Price from (R)-3-Methylmorpholine hydrochloride manufacturers

Hong Kong Tiansheng New Material Trading Co., Ltd
Product
(R)-3-Methylmorpholine hydrochloride 953780-78-4
Price
US $2.80/KG
Min. Order
1KG
Purity
98%
Supply Ability
10KG
Release date
2021-09-24
Hong Kong Tiansheng New Material Trading Co., Ltd
Product
(R)-3-methylmorpholine hydrochloride 953780-78-4
Price
US $2.80/KG
Min. Order
1KG
Purity
99%
Supply Ability
10kg
Release date
2021-11-26
Career Henan Chemical Co
Product
(R)-3-methylmorpholine hydrochloride 953780-78-4
Price
US $1.00/g
Min. Order
1g
Purity
95--99%
Supply Ability
1ton
Release date
2020-01-09

953780-78-4, (R)-3-Methylmorpholine hydrochlorideRelated Search:

2-Amino-5-chloro-3-nitropyridine 5-Bromo-2-iodopyrimidine 3,5-Dibromo-4-hydroxybenzoic acid 5-Chlorovaleric acid 4-Phenyl-2-butanol 3,5-Dihydroxybenzamide 1-Allylcyclopropane-1-sulfonyl chloride (1-Benzyl-4-piperidyl)methanol 4-AMINO-3,5-DIIODOPYRIDINE 4-Methoxybenzylchloride 4-Hydroxy-2,6-dimethylpyridine (R)-1-Boc-3-(hyroxymethyl)piperidine 2,3-Dibromopyridine 5-Bromo-1,2,3-trichlorobenzene 1,3-Dibromo-2,2-dimethoxypropane 7-Fluoro-6-nitro-4-hydroxyquinazoline 4-Methylmorpholine N-oxide monohydrate Methylmorpholine

  • O-Benzyl-L-Threoninebenzyleser oxalate
  • (3R)-3-Methylmorpholine hydrochloride 98%
  • Morpholine, 3-methyl-, hydrochloride, (3R)-
  • (R)-3-Methylmorpholine hydrochloride
  • (R)-3-MethylMorpholine HCl
  • (<i>R</i>)-3-Methylmorpholine Hydrochloride
  • Morpholine, 3-methyl-, hydrochloride (1:1), (3R)-
  • (3R)-3-Methylmorpholine hydrochloride
  • (3R)-3-methyl-Morpholine hydrochloride (1:1)
  • (R)-3-Methylmorpholine chloride
  • (3R)-3-Methylmorpholine HCl
  • 953780-78-4
  • 952780-70-4