ChemicalBook > CAS DataBase List > (R)-3-Methylmorpholine hydrochloride

(R)-3-Methylmorpholine hydrochloride

Product Name
(R)-3-Methylmorpholine hydrochloride
CAS No.
953780-78-4
Chemical Name
(R)-3-Methylmorpholine hydrochloride
Synonyms
(R)-3-MethylMorpholine HCl;(3R)-3-Methylmorpholine HCl;(R)-3-Methylmorpholine chloride;(R)-3-Methylmorpholine hydrochloride;(3R)-3-Methylmorpholine hydrochloride;O-Benzyl-L-Threoninebenzyleser oxalate;(3R)-3-Methylmorpholine hydrochloride 98%;(R)-3-Methylmorpholine Hydrochloride;Morpholine, 3-methyl-, hydrochloride, (3R)-;(3R)-3-methyl-Morpholine hydrochloride (1:1)
CBNumber
CB02520102
Molecular Formula
C5H12ClNO
Formula Weight
137.61
MOL File
953780-78-4.mol
More
Less

(R)-3-Methylmorpholine hydrochloride Property

Melting point:
123.0 to 127.0 °C
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
powder to crystal
color 
White to Orange to Green
More
Less

Safety

HS Code 
2934999090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

More
Less

N-Bromosuccinimide Price

TCI Chemical
Product number
M2847
Product name
(R)-3-Methylmorpholine Hydrochloride
Purity
>98.0%(T)
Packaging
200mg
Price
$47
Updated
2025/07/31
TCI Chemical
Product number
M2847
Product name
(R)-3-Methylmorpholine Hydrochloride
Purity
>98.0%(T)
Packaging
1g
Price
$138
Updated
2025/07/31
SynQuest Laboratories
Product number
4H56-5-CX
Product name
(R)-3-Methylmorpholine hydrochloride
Purity
98%
Packaging
250mg
Price
$70
Updated
2021/12/16
AK Scientific
Product number
X4857
Product name
(3R)-3-methylmorpholinehydrochloride
Packaging
1g
Price
$89
Updated
2021/12/16
Activate Scientific
Product number
AS12233-B
Product name
(R)-3-Methyl-morpholine HCl
Purity
95% ee
Packaging
1g
Price
$49
Updated
2021/12/16
More
Less

(R)-3-Methylmorpholine hydrochloride Chemical Properties,Usage,Production

Uses

(3R)-3-Methylmorpholine Hydrochloride is used in the discovery studies of novel 2-(alkylmorpholin-4-yl)-6-(3-fluoropyridin-4-yl)-pyrimidin-4(3H)-ones as orally active GSK-3β inhibitors for Alzheimer''s disease

Synthesis

954133-47-2

953780-78-4

General procedure for the synthesis of (R)-3-methylmorpholine hydrochloride from the compound (CAS: 954133-47-2): to a solution of (5R)-4-(4-methoxybenzyl)-5-methylmorpholine (17.8 g, 80.3 mmol) in 1,2-dichloroethane (180 mL) was added 1-chloroethyl chloroformate (46 g, 322 mmol). The reaction mixture was stirred at 80 °C for 6 hours. Upon completion of the reaction, the solvent was removed by evaporation under reduced pressure. The residue was dissolved in methanol (180 mL) and stirred at 80 °C for 1 hour. The solvent was again removed by evaporation under reduced pressure and the residue was washed with ethyl acetate and dried to give (3R)-3-methylmorpholine hydrochloride (8.2 g, 59.6 mmol, 74% yield) as white crystals.

References

[1] Patent: WO2007/119463, 2007, A1. Location in patent: Page/Page column 197; 198
[2] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 5, p. 1086 - 1091

(R)-3-Methylmorpholine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

(R)-3-Methylmorpholine hydrochloride Suppliers

Americas 1 China 102 Europe 1 India 5 Japan 1 United Kingdom 1 United States 5 Global 116
ShangHai DEMO Chemical Co.,Ltd
Tel
400-021-7337 2355568890
Fax
0086-21-50182339
Email
sales@demochem.com
Country
China
ProdList
2572
Advantage
57
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
Advantage
66
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9310
Advantage
66
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
16075
Advantage
64
Wuhan Arike Technology Co., Ltd.
Tel
027- 51832457 94518350
Fax
E-Mail Inquiry
Country
China
ProdList
746
Advantage
62
Xi'an Manareco New Materials Co., Ltd.
Tel
029-68669089-8816
Fax
+86-29-68669073
Email
market@xarlm.com
Country
China
ProdList
499
Advantage
55
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
Amatek Scientific Co. Ltd.
Tel
0512-56316828 4008675858
Fax
+86-512-56316826
Email
sales@amateksci.com
Country
China
ProdList
9874
Advantage
55
Taizhou Tongxin Bio-Tech Co., Ltd
Tel
0523-86818997 18652728585
Email
sales@allyrise.com
Country
China
ProdList
2966
Advantage
60
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Chengdu Firster Pharmaceutical Co., Ltd.
Tel
028-87078428 028-87074958
Fax
8772-8116
Email
chengzhenyong@cdfirster.com
Country
China
ProdList
2598
Advantage
60
Hunan HuaTeng Pharmaceutical Co., Ltd.,
Tel
400-8592883
Fax
0731-82251112
Email
sales@huatengsci.com
Country
China
ProdList
5872
Advantage
58
Shanghai Balmxy Pharmaceutical Co., Ltd
Tel
021-24206007 13764915196
Fax
86-021-23027023
Email
sales@balmxy.com
Country
China
ProdList
6874
Advantage
55
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10263
Advantage
55
Shanghai Xingui Biotechnology Co., Ltd.
Tel
15121041756
Email
xingui2022@126.com
Country
China
ProdList
9976
Advantage
58
Shanghai HuanChuan Industry Co.,Ltd.
Tel
021-61478794
Fax
021-61478794
Email
sales@hcshhai.com
Country
China
ProdList
9793
Advantage
50
Shanghai Yongye Biotechnology Co., Ltd.
Tel
86-021-61559134 15921386130
Fax
021-55068248
Email
3423497944@qq.com
Country
China
ProdList
8144
Advantage
55
Nanjing Endesa Bio-tech Co., Ltd.
Tel
025-58862853 18915922038
Fax
+86-025-58862853
Email
sales@endesachem.com
Country
China
ProdList
591
Advantage
58
JW & Y Pharmlab Co., Ltd.
Tel
021-64340559 13651849907;
Fax
021- 64345308
Email
xinyu_shi@jwypharmlab.com.cn
Country
China
ProdList
12000
Advantage
58
Shanghai Carlow Chemicals Co., Ltd.
Tel
21-33526724 18930996265
Fax
+86 21 37023730
Email
info@carlowchem.com
Country
China
ProdList
1969
Advantage
50
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Shanghai Changyan Chem & Tech Co., Ltd.
Tel
021-20242659 18930833303
Fax
+86 (21) 2024-2659
Email
Sales@changyanchem.cn
Country
China
ProdList
5001
Advantage
55
ChengDu TongChuangYuan Pharmaceutical Co.Ltd
Tel
028-83379370 13880556291
Fax
028-87747383
Email
tcy@tcypharm.com
Country
China
ProdList
7218
Advantage
58
Zhengzhou Acme Chemical Co., Ltd.
Tel
0371-0371-55629727 13323845623
Fax
037155629727
Email
2885676761@qq.com
Country
China
ProdList
10110
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Nanjing YakeLun Pharmaceutical Co., Ltd.
Tel
025-66096098 3165145969
Fax
QQ3165145969
Email
sales@accoronpharm.com
Country
China
ProdList
3924
Advantage
55
Hangzhou Molcore Biopharmatech Co.,Ltd
Tel
400-711-5280 86-571-81025280
Fax
86-571-85806285
Email
sales@molcore.com
Country
China
ProdList
9967
Advantage
58
Wuxi AppTec
Tel
022-59987777 13552403979
Email
jia_guoqiang@wuxiapptec.com
Country
China
ProdList
22345
Advantage
58
Capot Chemical Co.,Ltd.
Tel
+86-（0）57185586718; +8613336195806
Fax
+86-571-85864795
Email
sales@capot.com
Country
China
ProdList
29735
Advantage
60
Aikon International Limited
Tel
025-66061636 18013972705
Fax
(3)02557626880
Email
qqyang@aikonchem.com
Country
China
ProdList
15814
Advantage
58
SHANGHAI FDC-CHEMICAL CO.,LTD
Tel
021-61469567 13482353728
Fax
021-61161605
Email
sales@fdc-chemical.com
Country
China
ProdList
9717
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 400821072
Fax
021-58955996
Email
malulu@leyan.com
Country
China
ProdList
25000
Advantage
58
Jinan Kabotang Biological Technology Co.,Ltd.
Tel
0531-61320525 15866703830
Email
figo.gao@foxmail.com
Country
China
ProdList
5178
Advantage
58
3A Chemicals
Tel
400-668-9898
Fax
010-51582189
Email
service@3achem.com
Country
China
ProdList
20557
Advantage
58
TCI Chemicals
Tel
021-67121386, 800-988-0390
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
5391
Advantage
58
Hefei Molake Biotechnology Co., Ltd.
Tel
0551-66336380 18956014586
Fax
055166336380
Email
983438788@qq.com
Country
China
ProdList
2297
Advantage
58
Shanghai zhigan biotechnology co., LTD
Tel
Email
zhiqianbio@126.com
Country
China
ProdList
19778
Advantage
58
Jinan Carbotang Biotech Co.,Ltd.
Tel
+8615866703830
Email
figo.gao@foxmail.com
Country
China
ProdList
8497
Advantage
58
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
+86-0551-65418684 +8618949823763
Fax
0086-551-65418684
Email
sales@tnjchem.com
Country
China
ProdList
25356
Advantage
58
Labnetwork lnc.
Tel
+86-27-50766799 +8618062016861
Email
contact@labnetwork.com
Country
China
ProdList
19987
Advantage
58
sgtlifesciences pvt ltd
Tel
+8617013299288
Email
dj@sgtlifesciences.com
Country
China
ProdList
12373
Advantage
58
Nextpeptide Inc
Tel
+86-0571-81612335 +8613336028439
Email
sales@nextpeptide.com
Country
China
ProdList
19908
Advantage
58
Hong Kong Tiansheng New Material Trading Co., Ltd
Tel
+8617320695765
Fax
17320695765
Email
zxx@hktiansheng.com
Country
China
ProdList
973
Advantage
58
Dayang Chem (Hangzhou) Co.,Ltd.
Tel
+86-0571-88938639 +8617705817739
Fax
+86-571-88938652，+86-571- 88492614
Email
info@dycnchem.com
Country
China
ProdList
52846
Advantage
58
Career Henan Chemica Co
Tel
+86-0371-86658258 +8613203830695
Fax
0371-86658258
Email
laboratory@coreychem.com
Country
China
ProdList
30229
Advantage
58
Shanghai Qitong Pharmaceutical Technology Co., Ltd.
Tel
18918399319
Email
24907461@qq.com
Country
China
ProdList
259
Advantage
58
Chongqing Chemdad Co., Ltd
Tel
+86-023-6139-8061 +86-86-13650506873
Email
sales@chemdad.com
Country
China
ProdList
39927
Advantage
58
Shanghai Boyi Biomedical Technology Co., Ltd.
Tel
021-021-54331997 18321536537
Email
info@ansionpharma.com
Country
China
ProdList
2336
Advantage
58
CONIER CHEM AND PHARMA LIMITED
Tel
+8618523575427
Email
sales@conier.com
Country
China
ProdList
49975
Advantage
58
More
Less

View Lastest Price from (R)-3-Methylmorpholine hydrochloride manufacturers

Hong Kong Tiansheng New Material Trading Co., Ltd
Product
(R)-3-Methylmorpholine hydrochloride 953780-78-4
Price
US $2.80/KG
Min. Order
1KG
Purity
98%
Supply Ability
10KG
Release date
2021-09-24
Hong Kong Tiansheng New Material Trading Co., Ltd
Product
(R)-3-methylmorpholine hydrochloride 953780-78-4
Price
US $2.80/KG
Min. Order
1KG
Purity
99%
Supply Ability
10kg
Release date
2021-11-26
Career Henan Chemical Co
Product
(R)-3-methylmorpholine hydrochloride 953780-78-4
Price
US $1.00/g
Min. Order
1g
Purity
95--99%
Supply Ability
1ton
Release date
2020-01-09

953780-78-4, (R)-3-Methylmorpholine hydrochlorideRelated Search:

2-Amino-5-chloro-3-nitropyridine 5-Bromo-2-iodopyrimidine 3,5-Dibromo-4-hydroxybenzoic acid 5-Chlorovaleric acid 4-Phenyl-2-butanol 3,5-Dihydroxybenzamide 1-Allylcyclopropane-1-sulfonyl chloride (1-Benzyl-4-piperidyl)methanol 4-AMINO-3,5-DIIODOPYRIDINE 4-Methoxybenzylchloride 4-Hydroxy-2,6-dimethylpyridine (R)-1-Boc-3-(hyroxymethyl)piperidine 2,3-Dibromopyridine 5-Bromo-1,2,3-trichlorobenzene 1,3-Dibromo-2,2-dimethoxypropane 7-Fluoro-6-nitro-4-hydroxyquinazoline 4-Methylmorpholine N-oxide monohydrate Methylmorpholine

  • O-Benzyl-L-Threoninebenzyleser oxalate
  • (3R)-3-Methylmorpholine hydrochloride 98%
  • Morpholine, 3-methyl-, hydrochloride, (3R)-
  • (R)-3-Methylmorpholine hydrochloride
  • (R)-3-MethylMorpholine HCl
  • (<i>R</i>)-3-Methylmorpholine Hydrochloride
  • Morpholine, 3-methyl-, hydrochloride (1:1), (3R)-
  • (3R)-3-Methylmorpholine hydrochloride
  • (3R)-3-methyl-Morpholine hydrochloride (1:1)
  • (R)-3-Methylmorpholine chloride
  • (3R)-3-Methylmorpholine HCl
  • 953780-78-4
  • 952780-70-4