ChemicalBook > CAS DataBase List > PH 797804

PH 797804

Product Name
PH 797804
CAS No.
586379-66-0
Chemical Name
PH 797804
Synonyms
3-(4-(2,4-difluorobenzyloxy)-3-bromo-6-methyl-2-oxopyridin-1(2H)-yl)-N,4-dimethylbenzamide;CS-45;PH 797804;PH-797804, >=98%;PH 797804;PH797804;PH 797804 USP/EP/BP;PH-797804 PH797804 MAPK Inhibitor;PH 797804, (±)- - rac-PH 797804 | rac-PH 797804;3-(3-Bromo-4-((2,4-difluorobenzyl)oxy)-6-methyl-2-oxopyridin-1(2H)-yl)-N,4-dimethylbenzamide;3-Bromo-4-[(2,4-difluorobenzyl)oxy]-1-[5-[(methylamino)carbonyl]-2-methylphenyl]-6-methylpyridin-2(1H)-one
CBNumber
CB02522106
Molecular Formula
C22H19BrF2N2O3
Formula Weight
477.3
MOL File
586379-66-0.mol
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PH 797804 Property

Density 
1.51
storage temp. 
20-25°C
solubility 
≥23.85 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form 
powder
color 
white to beige
CAS DataBase Reference
586379-66-0
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PZ0259
Product name
PH-797804
Purity
≥98% (HPLC)
Packaging
5MG
Price
$112
Updated
2023/06/20
Sigma-Aldrich
Product number
PZ0259
Product name
PH-797804
Purity
≥98% (HPLC)
Packaging
25MG
Price
$451
Updated
2023/06/20
Cayman Chemical
Product number
20244
Product name
PH-797804
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
20244
Product name
PH-797804
Purity
≥98%
Packaging
5mg
Price
$172
Updated
2024/03/01
Cayman Chemical
Product number
20244
Product name
PH-797804
Purity
≥98%
Packaging
10mg
Price
$321
Updated
2024/03/01
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PH 797804 Chemical Properties,Usage,Production

Uses

PH-797804 is a novel N-phenylpyridinone inhibitor of p38 mitogen-activated protein (MAP) kinase derived from a racemic mixture as the more potent atropisomer and is also known to exerts anti-inflammatory properties.

Definition

ChEBI: A member of the class of benzamides obtained by formal condensation of the carboxy group of 3-{3-bromo-4-[(2,4-difluorobenzyl)oxy]-6-methyl-2-oxopyridin-1-yl}-4-methylbenzoic acid with the amino group of methylamine.

Biological Activity

ph-797804 is a novel, potent, atp-competitive and reversible inhibitor of human p38 map kinase. it specifically inhibits p38α with ic50 value of 26 nm and k(i) value of 5.8 nm.ph-797804 inhibits lps induced tnf-α and il-1β production in monocytes with a concentration-dependently manner. ph-797804 blocks rankl and m-csf induced osteoclast formation in primary rat bone marrow cells.orally administered ph-797804 suppresses tnf-α level in a dose-dependent manner in lps induced lewis rats and also in cynomolgus monkeys. additionally, ph-797804 has been shown to inhibit chronic inflammation in arthritis models induced by mouse collagen-induced or rat streptococcal cell wall (scw) extract.

Biochem/physiol Actions

PH-797804 is an orally active, potent and readily reversible ATP competitive inhibitor of the alpha isoform of human p38 MAP kinase. PH-797804 blocks inflammation-induced production of cytokines and proinflammatory mediators.

target

p38α

References

[1] hope hr1, anderson gd, burnette bl, compton rp, devraj rv, hirsch jl, keith rh, li x, mbalaviele g, messing dm, saabye mj,schindler jf, selness sr, stillwell li, webb eg, zhang j, monahan jb. anti-inflammatory properties of a novel n-phenyl pyridinone inhibitor of p38 mitogen-activated protein kinase: preclinical-to-clinical translation. j pharmacol exp ther. 2009 dec;331(3):882-95.

PH 797804 Preparation Products And Raw materials

Raw materials

Preparation Products

586379-66-0, PH 797804Related Search:


  • 3-(3-Bromo-4-((2,4-difluorobenzyl)oxy)-6-methyl-2-oxopyridin-1(2H)-yl)-N,4-dimethylbenzamide
  • PH 797804
  • 3-Bromo-4-[(2,4-difluorobenzyl)oxy]-1-[5-[(methylamino)carbonyl]-2-methylphenyl]-6-methylpyridin-2(1H)-one
  • 3-(4-(2,4-difluorobenzyloxy)-3-bromo-6-methyl-2-oxopyridin-1(2H)-yl)-N,4-dimethylbenzamide
  • PH-797804, >=98%
  • PH 797804, (±)- - rac-PH 797804 | rac-PH 797804
  • PH 797804;PH797804
  • CS-45
  • PH 797804 USP/EP/BP
  • 3-ChemicalbookBromo-4-[(2,4-difluorobenzyl)oxy]-1-[5-[(methylamino)carbonyl]-2-methylphenyl]-6-methylpyridin-2(1H)-one
  • PH-797804 PH797804 MAPK Inhibitor
  • 586379-66-0
  • C22H19BrF2N2O3
  • MAPK
  • Inhibitors