6-HYDROXY-2-NAPHTHALENEBORONIC ACID

Product Name: 6-HYDROXY-2-NAPHTHALENEBORONIC ACID
CAS No.: 173194-95-1
Chemical Name: 6-HYDROXY-2-NAPHTHALENEBORONIC ACID
Synonyms: EOS-61102;AKOS BRN-0430;6-HYDROXY-2-NAPHTALENEBORONIC ACID;(6-Hydroxy-2-naphthyl)boronic acid;6-HYDROXY-2-NAPTHALENE BORONIC ACID;6-HYDROXY-2-NAPHTHYLENEBORONIC ACID;6-HYDROXY-2-NAPHTHALENEBORONIC ACID;6-HYDROXYNAPHTHALENE-2-BORONIC ACID;6-hydroxynaphthalen-2-ylboronic acid;(6-Hydroxynaphthalen-2-yl)boronicaci
CBNumber: CB0253307
Molecular Formula: C10H9BO3
Formula Weight: 187.99
MOL File: 173194-95-1.mol

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6-HYDROXY-2-NAPHTHALENEBORONIC ACID Property

Melting point:: 218-224°C
Boiling point:: 458.6±37.0 °C(Predicted)
Density: 1.35±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 8.80±0.30(Predicted)
form: powder to crystal
color: Light yellow to Yellow to Orange
LogP: 2.47 at 21.6℃
CAS DataBase Reference: 173194-95-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
Hazard Note: Harmful/Irritant/Keep Cold
HS Code: 29319090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CDS015293
Product name: 6-hydroxy-2-naphthaleneboronic acid
Purity: AldrichCPR
Packaging: 100MG
Price: $73.1
Updated: 2025/07/31

TCI Chemical

Product number: H1402
Product name: 6-Hydroxy-2-naphthaleneboronic Acid (contains varying amounts of Anhydride)
Packaging: 1g
Price: $57
Updated: 2025/07/31

TCI Chemical

Product number: H1402
Product name: 6-Hydroxy-2-naphthaleneboronic Acid (contains varying amounts of Anhydride)
Packaging: 5g
Price: $167
Updated: 2025/07/31

TRC

Product number: H944640
Product name: 6-Hydroxynaphthalene-2-boronicAcid
Packaging: 1g
Price: $250
Updated: 2021/12/16

Synthonix

Product number: H3730
Product name: (6-Hydroxynaphthalen-2-yl)boronicacid
Purity: 98%
Packaging: 100mg
Price: $15
Updated: 2021/12/16

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6-HYDROXY-2-NAPHTHALENEBORONIC ACID Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

6-Hydroxynaphthalene-2-boronic acid can be used to synthesize inhibitors for oxygenase, tyrosine and phosphoinositide kinases. Tyrosine and phosphoinositide kinases are an attractive target for developing cancer drugs.

Synthesis

15231-91-1

173194-95-1

Under argon protection, 5.58 g (25 mmol) of 6-bromo-2-naphthol was dissolved in 125 mL of anhydrous tetrahydrofuran. After cooling the resulting solution to -70°C, 33 mL (55 mmol) of hexane solution of n-butyllithium was added slowly and dropwise over a period of 30 minutes. Maintaining -70°C, the reaction mixture was continued to be stirred for 1.5 hours. Subsequently, 11.5 mL (50 mmol) of triisopropyl borate was added and stirring was continued at the same temperature for 30 minutes. After that, the reaction mixture was allowed to slowly warm up to room temperature and stirred for 3 hours in the process. After completion of the reaction, 100 mL of 2 M hydrochloric acid was added to the mixture and stirred at room temperature for 2 hours. The reaction solution was separated and the aqueous phase was extracted with ethyl acetate. All organic phases were combined, washed with saturated sodium chloride solution, dried over anhydrous sodium sulfate and the solvent was subsequently evaporated. The residue was washed with dichloromethane in suspension to give 4.02 g of 6-hydroxy-2-naphthaleneboronic acid in 85% yield.

References

[1] Patent: EP2597094, 2013, A1. Location in patent: Paragraph 0093
[2] Patent: WO2007/68905, 2007, A1. Location in patent: Page/Page column 69-70
[3] Patent: US2004/44258, 2004, A1. Location in patent: Page 60

6-HYDROXY-2-NAPHTHALENEBORONIC ACID Preparation Products And Raw materials

Raw materials

Nitrogen Tin Tetrahydrofuran Diethyl ether Bromine Triisopropyl borate Acetic acid 6-Bromo-2-naphthol 2-Naphthol n-Butyllithium

Preparation Products

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6-HYDROXY-2-NAPHTHALENEBORONIC ACID Suppliers

Americas 1 China 163 Europe 2 France 2 Germany 8 India 12 Italy 1 Japan 2 Russia 1 Switzerland 1 United Kingdom 10 United States 22 Global 225

J & K SCIENTIFIC LTD.

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View Lastest Price from 6-HYDROXY-2-NAPHTHALENEBORONIC ACID manufacturers

Henan Fengda Chemical Co., Ltd

Product: (6-Hydroxy-2-naphthyl)boronic acid 173194-95-1
Price: US $200.00-1.00/KG
Min. Order: 1KG
Purity: 99%, 99.5% Sublimated
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-31

Zhuozhou Wenxi import and Export Co., Ltd

Product: 6-HYDROXY-2-NAPHTHALENEBORONIC ACID 173194-95-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Zhuozhou Wenxi import and Export Co., Ltd

Product: 6-Hydroxy-2-naphthaleneboronic Acid (contains varying amounts of Anhydride) 173194-95-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

173194-95-1, 6-HYDROXY-2-NAPHTHALENEBORONIC ACIDRelated Search:

4-Hydroxyphenylboronic acid 2-Hydroxyphenylboronic acid 4-phenylnaphthalen-1-ylboronic acid 6-HYDROXY-2-NAPHTHALENEBORONIC ACID 6-(BENZYLOXY)-2-NAPHTHYLBORONIC ACID 6-Ethoxy-2-naphthaleneboronic acid 6-METHOXY-2-NAPHTHALENEBORONIC ACID 6-T-BUTYLDIMETHYSILYLOXY-2-NAPHTHALENEBORONIC ACID 2-Naphthaleneboronic acid 2-(6-Benzyloxynaphthalen-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane 2-(6-METHOXY-2-NAPHTHYL)-5,5-DIMETHYL-1,3,2-DIOXABORINANE 2-(6-Methoxynaphthalen-2-yl)-4,4,6-trimethyl-1,3,2-dioxaborinane 6-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)-2-naphthol 2-(6-Benzyloxynaphthalen-2-yl)-4,4,6-trimethyl-1,3,2-dioxaborinane 6-(TETRAHYDRO-2H-PYRAN-2-YLOXY)-2-NAPHTHYLBORONIC ACID 6-PENTYLOXYNAPHTHALENE-2-BORONIC ACID 6-(4,4,6-Trimethyl-1,3,2-dioxaborinan-2-yl)-2-naphthol

6-HYDROXYNAPHTHALENE-2-BORONIC ACID

6-HYDROXY-2-NAPHTHALENEBORONIC ACID

6-HYDROXY-2-NAPHTHYLENEBORONIC ACID

AKOS BRN-0430

6-HYDROXY-2-NAPTHALENE BORONIC ACID

6-Hydroxynaphthalene-2-boronic acid 98%

6-HYDROXY-2-NAPHTALENEBORONIC ACID

6-Hydroxy-2-naphthaleneboronic acid ,98%

6-hydroxynaphthalen-2-ylboronic acid

6-Hydroxy-2-naphthaleneboronic Acid (contains varying aMounts of Anhydride)

EOS-61102

(6-hydroxy-2-naphthalenyl)-boronic acid

Boronic acid, B-(6-hydroxy-2-naphthalenyl)-

(6-Hydroxy-2-naphthyl)boronic acid

(6-Hydroxynaphthalen-2-yl)boronicaci

(6-Hydroxynaphthalen-2-yl)boronic acid - [H3730]

(6-Hydroxynaphtha|en -2- y|)boronic acid

173194-95-1

C10H9BO3

6

blocks

BoronicAcids