6-HYDROXY-2-NAPHTHALENEBORONIC ACID
- Product Name
- 6-HYDROXY-2-NAPHTHALENEBORONIC ACID
- CAS No.
- 173194-95-1
- Chemical Name
- 6-HYDROXY-2-NAPHTHALENEBORONIC ACID
- Synonyms
- EOS-61102;AKOS BRN-0430;6-HYDROXY-2-NAPHTALENEBORONIC ACID;(6-Hydroxy-2-naphthyl)boronic acid;6-HYDROXY-2-NAPTHALENE BORONIC ACID;6-HYDROXY-2-NAPHTHYLENEBORONIC ACID;6-HYDROXY-2-NAPHTHALENEBORONIC ACID;6-HYDROXYNAPHTHALENE-2-BORONIC ACID;6-hydroxynaphthalen-2-ylboronic acid;(6-Hydroxynaphthalen-2-yl)boronicaci
- CBNumber
- CB0253307
- Molecular Formula
- C10H9BO3
- Formula Weight
- 187.99
- MOL File
- 173194-95-1.mol
6-HYDROXY-2-NAPHTHALENEBORONIC ACID Property
- Melting point:
- 218-224°C
- Boiling point:
- 458.6±37.0 °C(Predicted)
- Density
- 1.35±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 8.80±0.30(Predicted)
- form
- powder to crystal
- color
- Light yellow to Yellow to Orange
- LogP
- 2.47 at 21.6℃
- CAS DataBase Reference
- 173194-95-1(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- Hazard Note
- Harmful/Irritant/Keep Cold
- HS Code
- 29319090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- CDS015293
- Product name
- 6-hydroxy-2-naphthaleneboronic acid
- Purity
- AldrichCPR
- Packaging
- 100MG
- Price
- $73.1
- Updated
- 2025/07/31
- Product number
- H1402
- Product name
- 6-Hydroxy-2-naphthaleneboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 1g
- Price
- $57
- Updated
- 2025/07/31
- Product number
- H1402
- Product name
- 6-Hydroxy-2-naphthaleneboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 5g
- Price
- $167
- Updated
- 2025/07/31
- Product number
- H944640
- Product name
- 6-Hydroxynaphthalene-2-boronicAcid
- Packaging
- 1g
- Price
- $250
- Updated
- 2021/12/16
- Product number
- H3730
- Product name
- (6-Hydroxynaphthalen-2-yl)boronicacid
- Purity
- 98%
- Packaging
- 100mg
- Price
- $15
- Updated
- 2021/12/16
6-HYDROXY-2-NAPHTHALENEBORONIC ACID Chemical Properties,Usage,Production
Chemical Properties
White solid
Uses
6-Hydroxynaphthalene-2-boronic acid can be used to synthesize inhibitors for oxygenase, tyrosine and phosphoinositide kinases. Tyrosine and phosphoinositide kinases are an attractive target for developing cancer drugs.
Synthesis
15231-91-1
173194-95-1
Under argon protection, 5.58 g (25 mmol) of 6-bromo-2-naphthol was dissolved in 125 mL of anhydrous tetrahydrofuran. After cooling the resulting solution to -70°C, 33 mL (55 mmol) of hexane solution of n-butyllithium was added slowly and dropwise over a period of 30 minutes. Maintaining -70°C, the reaction mixture was continued to be stirred for 1.5 hours. Subsequently, 11.5 mL (50 mmol) of triisopropyl borate was added and stirring was continued at the same temperature for 30 minutes. After that, the reaction mixture was allowed to slowly warm up to room temperature and stirred for 3 hours in the process. After completion of the reaction, 100 mL of 2 M hydrochloric acid was added to the mixture and stirred at room temperature for 2 hours. The reaction solution was separated and the aqueous phase was extracted with ethyl acetate. All organic phases were combined, washed with saturated sodium chloride solution, dried over anhydrous sodium sulfate and the solvent was subsequently evaporated. The residue was washed with dichloromethane in suspension to give 4.02 g of 6-hydroxy-2-naphthaleneboronic acid in 85% yield.
References
[1] Patent: EP2597094, 2013, A1. Location in patent: Paragraph 0093
[2] Patent: WO2007/68905, 2007, A1. Location in patent: Page/Page column 69-70
[3] Patent: US2004/44258, 2004, A1. Location in patent: Page 60
6-HYDROXY-2-NAPHTHALENEBORONIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
6-HYDROXY-2-NAPHTHALENEBORONIC ACID Suppliers
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View Lastest Price from 6-HYDROXY-2-NAPHTHALENEBORONIC ACID manufacturers
- Product
- (6-Hydroxy-2-naphthyl)boronic acid 173194-95-1
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%, 99.5% Sublimated
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-31
- Product
- 6-HYDROXY-2-NAPHTHALENEBORONIC ACID 173194-95-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- 6-Hydroxy-2-naphthaleneboronic Acid (contains varying amounts of Anhydride) 173194-95-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27