ChemicalBook > CAS DataBase List > MC-Val-Cit-PAB

MC-Val-Cit-PAB

Product Name
MC-Val-Cit-PAB
CAS No.
159857-80-4
Chemical Name
MC-Val-Cit-PAB
Synonyms
N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide;6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)hexanamide;MC-Val-Cit-PAB-OH;EOS-60616;MC-Val-it-PAB;MC-Val-Cit-PAB;ML-Val-Cit-PAB;MC-Val-Cit-PAB/MC-VC-PAB-OH;Benzenemethanol,2-chloro-8-nitro-;MC-Val-Cit-PAB (ADC peptide linker)
CBNumber
CB02554361
Molecular Formula
C28H40N6O7
Formula Weight
572.65
MOL File
159857-80-4.mol
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MC-Val-Cit-PAB Property

Boiling point:
931.6±65.0 °C(Predicted)
Density 
1.276
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
DMSO: soluble
form 
powder to crystal
pka
13.41±0.70(Predicted)
color 
White to Almost white
InChIKey
UMDCMQHPXQLHGR-OFVILXPXSA-N
SMILES
C(N)(=O)[C@H](CCCNC(N)=O)N(C(=O)[C@H](C(C)C)NC(=O)CCCCCN1C(=O)C=CC1=O)C1=CC=C(CO)C=C1
CAS DataBase Reference
159857-80-4
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
M3224
Product name
MC-Val-Cit-PAB-OH
Packaging
100MG
Price
$281
Updated
2024/03/01
TCI Chemical
Product number
M3224
Product name
MC-Val-Cit-PAB-OH
Packaging
500MG
Price
$845
Updated
2024/03/01
Cayman Chemical
Product number
28285
Product name
Mc-Val-Cit-PAB
Packaging
5mg
Price
$100
Updated
2024/03/01
Cayman Chemical
Product number
28285
Product name
Mc-Val-Cit-PAB
Packaging
50mg
Price
$739
Updated
2024/03/01
Cayman Chemical
Product number
28285
Product name
Mc-Val-Cit-PAB
Packaging
1mg
Price
$34
Updated
2024/03/01
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MC-Val-Cit-PAB Chemical Properties,Usage,Production

Description

MC-Val-Cit-PAB-OH is a cleavable peptide linker. The Val-Cit was designed to be cleaved specifically by Cathepsin B. MC group is reactive with thiol moiety

Uses

N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide is used as a reagent to prepare antibody-drug conjugates, which are compounds that selectively deliver cytotoxic drugs to a tumour-associated antigen.

MC-Val-Cit-PAB Preparation Products And Raw materials

Raw materials

Preparation Products

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MC-Val-Cit-PAB Suppliers

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View Lastest Price from MC-Val-Cit-PAB manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
MC-Val-Cit-PAB-OH 159857-80-4
Price
US $0.00/g
Min. Order
1g
Purity
>98.00%
Supply Ability
1g
Release date
2024-03-29
Career Henan Chemical Co
Product
N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide 159857-80-4
Price
US $6.68/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg-1000kg
Release date
2020-01-08

159857-80-4, MC-Val-Cit-PABRelated Search:

FMoc-Val-Cit-PAB-PNP Val-cit-PAB-OH pyrene-2,7-diyldiboronic acid Fmoc-Val-Cit-OH FMoc-Val-Cit-PAB

  • MC-Val-it-PAB
  • N-[(2S)-1-[[(2S)-5-(carbamoylamino)-1-[4-(hydroxymethyl)anilino]-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-6-(2,5-dioxopyrrol-1-yl)hexanamide
  • N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide
  • L-OrnithinaMide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aMinocarbonyl)-N-[4-(hydroxyMethyl)phenyl]-
  • 6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)hexanamide
  • ML-Val-Cit-PAB
  • MC-Val-Cit-PAB, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-
  • MC-Val-Cit-PAB
  • EOS-60616
  • MC-Val-Cit-PAB-OH
  • N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymeth
  • 6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-[(S)-1-[[(S)-1-[[4-(hydroxymethyl)phenyl]amino]-1-oxo-5-ureidopentan-2-yl]amino]-3-methyl-1-ox
  • N-[6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]-L-valyl-N5-carbamoyl-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide
  • 6-(2,5-Dioxo-2,5-dihydro-1-pyrrolyl)-N-[(S)-1-[[(S)-1-[[4-(hydroxymethyl)phenyl]amino]-1-oxo-5-ureido-2-pentyl]amino]-3-methyl-1-oxo-2-butyl]hexanamide
  • N-[6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]-L-valyl-N<sup>5</sup>-carbamoyl-N<sup>2</sup>-[4-(hydroxymethyl)phenyl]-L-ornithinamide
  • Benzenemethanol,2-chloro-8-nitro-
  • MC-Val-Cit-PAB (ADC peptide linker)
  • 6-(2,5-dioxopyrrol-1-yl)-N-[(1S)-1-[[(1S)-1-[[4-(hydroxymethyl)phenyl]carbamoyl]-4-ureido-butyl]carbamoyl]-2-methyl-propyl]hexanamide
  • MC-Val-Cit-PAB/MC-VC-PAB-OH
  • 159857-80-4
  • 59857-80-4
  • C28H40N6O7
  • ADCs
  • ADC Linker
  • ADC-Linker
  • ADC-Linkers