FMoc-Val-Cit-PAB

Uses

Product Name: FMoc-Val-Cit-PAB
CAS No.: 159858-22-7
Chemical Name: FMoc-Val-Cit-PAB
Synonyms: Fmoc-Val-Cit-PAB-OH;(9H-fluoren-9-yl)methyl ((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate;FMoc-Val-Cit-PAB;Fomc-Val-Cit-PAB;TrastuzumabImpurity2;Fmoc-L-Val-Cit-PAB-OH;Fmoc-val-citrulline-para-aminobenzyl-OH;Trastuzumab Impurity 2 (Fmoc-Val-Cit-PAB-OH);4-(N-((9H-fluoren-9-yl)methoxycarbonyl)-L-valinyl-D-citrullinamido)benzyl alcohol;N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide
CBNumber: CB02730901
Molecular Formula: C33H39N5O6
Formula Weight: 601.69
MOL File: 159858-22-7.mol

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FMoc-Val-Cit-PAB Property

Melting point:: 204 °C(dec.)
Boiling point:: 914.2±65.0 °C(Predicted)
Density: 1.276±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
form: powder to crystal
pka: 10.63±0.46(Predicted)
color: White to Almost white
InChIKey: BJFFTMRUMPZMSZ-VMPREFPWSA-N
SMILES: C(N)(=O)[C@H](CCCNC(N)=O)N(C(=O)[C@H](C(C)C)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O)C1=CC=C(CO)C=C1
CAS DataBase Reference: 159858-22-7

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Safety

HS Code: 2924.29.7790

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TCI Chemical

Product number: F1223
Product name: Fmoc-Val-Cit-PAB-OH
Packaging: 25MG
Price: $16
Updated: 2025/07/31

TCI Chemical

Product number: F1223
Product name: Fmoc-Val-Cit-PAB-OH
Packaging: 100MG
Price: $35
Updated: 2025/07/31

AK Scientific

Product number: 2998DP
Product name: Fmoc-Val-Cit-PAB
Packaging: 25mg
Price: $259
Updated: 2021/12/16

ChemScene

Product number: CS-5170
Product name: Fmoc-Val-Cit-PAB
Purity: 97.15%
Packaging: 250mg
Price: $300
Updated: 2021/12/16

Iris Biotech GmbH

Product number: ADC1030
Product name: Fmoc-Val-Cit-PAB
Packaging: 250mg
Price: $303.75
Updated: 2021/12/16

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FMoc-Val-Cit-PAB Chemical Properties,Usage,Production

Uses

Fmoc-Val-Cit-PAB is a commonly used bridge for a degradable antibody-conjugated drug (ADC).

Description

Fmoc-Val-Cit-PAB-OH is a cleavable ADC linker. The Val-Cit will specifically be cleaved by Cathepsin B. As this enzyme is only present in the lysosome, the ADC payload will be released only in the cell. Fmoc can be deprotected under basic condition.

Uses

Fmoc-Val-Cit-PAB is a cleavable antibody-conjugated active molecule (ADC) commonly used linker.

Synthesis

159858-21-6

623-04-1

159858-22-7

The general procedure for the synthesis of the target compound (CAS:159858-22-7) from (S)-2-((S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-methylbutanoylamino) and p-aminobenzenemethanol (PABOH) was carried out as follows: 60 ml of dichloromethane (DCM) mixed with methanol (MeOH) in the ratio of 2:1, by volume of the Solvent was added to the reaction flask, followed by 4.2 mmol Fmoc-vc2g and 1.04 g (2 eq.) of PABOH. after stirring until complete dissolution, 2.0 g (2 eq.) of EEDQ was added. the reaction system was protected from light at room temperature, and the reaction was continuously stirred for 2.0 days. After completion of the reaction, the reaction mixture was concentrated under reduced pressure at 40 °C to give a white solid. The white solid was collected, 100 ml of methyl tert-butyl ether (MTBE) was added, stirred and filtered, and the filter cake was washed with methyl tert-butyl ether. The resulting white solid was dried under reduced pressure at 40 °C to give 2.2 g of the target product in about 88% yield.

IC 50

Protease Cleavable Linker; Cleavable Linker

References

[1] International Journal of Molecular Sciences, 2017, vol. 18, # 9,
[2] Patent: CN107789630, 2018, A. Location in patent: Paragraph 0073; 0074; 0075
[3] Patent: WO2017/66668, 2017, A1. Location in patent: Paragraph 000187-000189
[4] Journal of Controlled Release, 2012, vol. 160, # 3, p. 618 - 629
[5] Patent: KR2017/41562, 2017, A. Location in patent: Paragraph 0431-0432

FMoc-Val-Cit-PAB Preparation Products And Raw materials

Raw materials

Preparation Products

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FMoc-Val-Cit-PAB Suppliers

Americas 1 China 239 Europe 1 India 4 Japan 1 United States 7 Global 253

Chemyouth Life Science（Suzhou）Co.,Ltd

Tel: 13752065514
Email: jianwei@chemyouth.com
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Shenzhen Yuzhong Pharmaceutical Technology Co., Ltd.

Tel: 13414494621
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Email: chenchao02lzu@126.com
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Zhenjiang Renzhi Biotechnology Co., Ltd.

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Email: 865612999@qq.com
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Changzhou PBpharmaceutical R&D Co.,Ltd

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Email: info@pbpharm.com
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Hangzhou Sinoda Pharmaceutical Technology Co. LTD

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Shanghai Yanfen Biochemical Technology Co.,LTD

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Suzhou Yimaike Pharmaceutical Co., Ltd.

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Hunan Hui Bai Shi Biotechnology Co., Ltd.

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Email: ivy@hnhbsj.com
Country: China
ProdList: 7247
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Chengdu Pukang Biotechnology Co., Ltd

Tel: +86-028-82550498 +86-19102685862
Fax: 086-28-82550468
Email: sales@pu-kang.com
Country: China
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Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9510
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View Lastest Price from FMoc-Val-Cit-PAB manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: FMoc-Val-Cit-PAB 159858-22-7
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-05-24

Henan Aochuang Chemical Co.,Ltd.

Product: FMoc-Val-Cit-PAB 159858-22-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-13

Xian confluore Biological Technology Co., Ltd.

Product: Fmoc-Val-Cit-PAB-OH 159858-22-7
Price: US $0.00/g
Min. Order: 10g
Purity: >95.00%
Supply Ability: 10g
Release date: 2024-03-29

159858-22-7, FMoc-Val-Cit-PABRelated Search:

FMoc-Val-Cit-PAB-PNP Val-cit-PAB-OH pyrene-2,7-diyldiboronic acid Fmoc-Val-Cit-OH MC-Val-Cit-PAB N-[(9H-Fluoren-9-ylmethoxy)carbonyl]glycylglycylglycylglycine Fmoc-Val-Ala-OH H-GLY-GLY-PHE-OH Fmoc-Val-Ala-PAB-OH Fomc-Gly-Gly-Phe-Gly-OH

FMoc-Val-Cit-PAB

Fmoc-Val-Cit-PAB-OH

(9H-fluoren-9-yl)methyl ((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate

L-Ornithinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-

(9H-fluoren-9-yl)methyl((S)-1-((())-1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate

(9H-fluoren-9-yl)methyl N-[(1S)-1-{[(1S)-4-(carbamoylamino)-1-{[4-(hydroxymethyl)phenyl]carbamoyl}butyl]carbamoyl}-2-methylpropyl]carbamate

Fmoc-val-citrulline-para-aminobenzyl-OH

(9H-fluoren-9-yl)methyl ((2S)-1-((1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate

4-(N-((9H-fluoren-9-yl)methoxycarbonyl)-L-valinyl-D-citrullinamido)benzyl alcohol

TrastuzumabImpurity2

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide

9H-fluoren-9-yl)methyl ((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbam

9H-fluoren-9-ylmethyl N-[(2S)-1-[[(2S)-5-(carbamoylamino)-1-[4-(hydroxymethyl)anilino]-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate

Trastuzumab Impurity 2 (Fmoc-Val-Cit-PAB-OH)

Fmoc-L-Val-Cit-PAB-OH

Fomc-Val-Cit-PAB

159858-22-7

159858-22-8

1959858-22-7

ADCs

ADC Linker

ADC-Linker

ADC-Linkers