Fmoc-Val-Ala-OH

Product Name: Fmoc-Val-Ala-OH
CAS No.: 150114-97-9
Chemical Name: Fmoc-Val-Ala-OH
Synonyms: Fmoc-Val-Ala;(((9H-Fluoren-9-yl)methoxy)carbonyl)-L-valyl-L-alanine;Fmoc-Val-Ala-OH;N-Fmoc-L-valyl-L-alanine;(9H-Fluoren-9-yl)MethOxy]Carbonyl Val-Ala-OH;N-(9-fluorenylmethoxycarbonyl)-L-valyl-L-alanine;(((9H-fluoren-9-yl)methoxy)carbonyl)-D-valyl-L-alanine;N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-valyl-L-alanine;L-Alanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-valyl-;(((9H-Fluoren-9-yl)methoxy)carbonyl)-L-valyl-L-alanine - [F88310]
CBNumber: CB43054763
Molecular Formula: C23H26N2O5
Formula Weight: 410.46
MOL File: 150114-97-9.mol

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Fmoc-Val-Ala-OH Property

Melting point:: 217 - 219°C
Boiling point:: 676.7±45.0 °C(Predicted)
Density: 1.236±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMF (Slightly), DMSO (Slightly)
form: Solid
pka: 3.47±0.10(Predicted)
color: White to Off-White
InChIKey: KQZMZNLKVKGMJS-XOBRGWDASA-N
SMILES: C(O)(=O)[C@H](C)NC(=O)[C@H](C(C)C)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O

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Safety

WGK Germany: WGK 3
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-24076
Product name: Fmoc-Val-Ala-OH
Purity: 95%
Packaging: 1g
Price: $350
Updated: 2021/12/16

Activate Scientific

Product number: AS117516
Product name: Fmoc-Val-Ala-OH
Purity: 97+%
Packaging: 5G
Price: $412
Updated: 2021/12/16

Ambeed

Product number: A597473
Product name: (S)-2-((S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-methylbutanamido)propanoicacid
Purity: 97%
Packaging: 25g
Price: $450
Updated: 2021/12/16

BLDpharm

Product number: BD628448
Product name: (S)-2-((S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-methylbutanamido)propanoicacid
Purity: 97%
Packaging: 25g
Price: $459
Updated: 2021/12/16

BLDpharm

Product number: BD628448
Product name: (S)-2-((S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-methylbutanamido)propanoicacid
Purity: 97%
Packaging: 250mg
Price: $16
Updated: 2021/12/16

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Fmoc-Val-Ala-OH Chemical Properties,Usage,Production

Uses

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-valyl-L-alanine is a reagent used in the synthesis of novel antibody-drug candidates in the improvement of current cancer treatment strategies.

Synthesis

1115-74-8

28920-43-6

150114-97-9

The general procedure for the synthesis of N-[Fmoc]-L-valyl-L-alanine from the compound (CAS:1115-74-8) and 9-fluorenylmethyl chloroformate is as follows: (a) (R)-2-((R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-methylbutanoylpropionic acid (20a, 350 mg, 1.86 mmol) and Na2CO3 (493 mg, 4.65 mmol) were dissolved in distilled water (15 mL) and the mixture was cooled to 0 °C. Dioxane (15 mL) was then added (some precipitation appeared). A solution of Fmoc-Cl (504 mg, 1.95 mmol) in dioxane (15 mL) was added dropwise with vigorous stirring over 10 min. The resulting mixture was stirred at 0°C for 2 hours. After removing the ice bath, stirring was continued for 16 hours. The solvent was removed by rotary evaporation under reduced pressure and the residue was dissolved in water (150 mL). The pH was adjusted from 9 to 2 with aqueous 1N HCl. The aqueous layer was subsequently extracted with EtOAc (3 x 100 mL). The organic layers were combined, washed with brine (100 mL), dried with MgSO4, filtered and the volatiles were removed by rotary evaporation under reduced pressure to give pure HO-Ala-Val-Fmoc (20b, 746 mg, 97% yield). LC/MS analysis: 2.85 min (ES+) m/z (relative intensity) 410.60. 1H-NMR (400 MHz, CDCl3) δ 7.79 (d, J = 7.77 Hz, 2H), 7.60 (d, J = 7.77 Hz, 2H), 7.43 (d, J = 7.5 Hz, 2H), 7.34 (d, J = 7.5 Hz, 2H), 6.30 (bs, 1H), 5.30 (bs, 1H), 4.71- 7.56 (m, 1H), 4.54-4.36 (m, 2H), 4.08-3.91 (m, 1H), 2.21-2.07 (m, 1H), 1.50 (d, J = 1AHz, 3H), 1.06-0.90 (m, 6H).

References

[1] Patent: WO2014/57073, 2014, A1. Location in patent: Page/Page column 123; 124
[2] Patent: WO2014/57072, 2014, A1. Location in patent: Page/Page column 43
[3] Patent: WO2014/96365, 2014, A1. Location in patent: Page/Page column 200-201
[4] Patent: WO2014/130879, 2014, A2. Location in patent: Page/Page column 124; 125
[5] Patent: WO2015/52533, 2015, A1. Location in patent: Page/Page column 47; 48

Fmoc-Val-Ala-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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Fmoc-Val-Ala-OH Suppliers

China 108 India 1 United States 3 Global 112

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View Lastest Price from Fmoc-Val-Ala-OH manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Fmoc-Val-Ala-OH 150114-97-9
Price: US $0.00/g
Min. Order: 25g
Purity: >95.00%
Supply Ability: 25g
Release date: 2024-03-29

150114-97-9, Fmoc-Val-Ala-OHRelated Search:

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(2S)-2-[(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methylbutanamido]propanoic acid

N-(9-fluorenylmethoxycarbonyl)-L-valyl-L-alanine

(9H-Fluoren-9-yl)MethOxy]Carbonyl Val-Ala-OH

Fmoc-Val-Ala-OH

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-valyl-L-alanine

L-Alanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-valyl-

(((9H-Fluoren-9-yl)methoxy)carbonyl)-L-valyl-L-alanine

Fmoc-Val-Ala

N-Fmoc-L-valyl-L-alanine

(2S)-2-[[(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methylbutanoyl]amino]propanoic acid

(((9H-fluoren-9-yl)methoxy)carbonyl)-D-valyl-L-alanine

(((9H-Fluoren-9-yl)methoxy)carbonyl)-L-valyl-L-alanine - [F88310]

150114-97-9

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