ChemicalBook > CAS DataBase List > MC-Val-Cit-PAB

MC-Val-Cit-PAB

Product Name
MC-Val-Cit-PAB
CAS No.
159857-80-4
Chemical Name
MC-Val-Cit-PAB
Synonyms
N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide;6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)hexanamide;MC-Val-Cit-PAB-OH;EOS-60616;MC-Val-it-PAB;MC-Val-Cit-PAB;ML-Val-Cit-PAB;MC-Val-Cit-PAB/MC-VC-PAB-OH;Benzenemethanol,2-chloro-8-nitro-;MC-Val-Cit-PAB (ADC peptide linker)
CBNumber
CB02554361
Molecular Formula
C28H40N6O7
Formula Weight
572.65
MOL File
159857-80-4.mol
More
Less

MC-Val-Cit-PAB Property

Boiling point:
931.6±65.0 °C(Predicted)
Density 
1.276
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
DMSO: soluble
form 
powder to crystal
pka
13.41±0.70(Predicted)
color 
White to Almost white
InChIKey
UMDCMQHPXQLHGR-OFVILXPXSA-N
SMILES
C(N)(=O)[C@H](CCCNC(N)=O)N(C(=O)[C@H](C(C)C)NC(=O)CCCCCN1C(=O)C=CC1=O)C1=CC=C(CO)C=C1
CAS DataBase Reference
159857-80-4
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

TCI Chemical
Product number
M3224
Product name
MC-Val-Cit-PAB-OH
Packaging
100MG
Price
$281
Updated
2024/03/01
TCI Chemical
Product number
M3224
Product name
MC-Val-Cit-PAB-OH
Packaging
500MG
Price
$845
Updated
2024/03/01
Cayman Chemical
Product number
28285
Product name
Mc-Val-Cit-PAB
Packaging
5mg
Price
$100
Updated
2024/03/01
Cayman Chemical
Product number
28285
Product name
Mc-Val-Cit-PAB
Packaging
50mg
Price
$739
Updated
2024/03/01
Cayman Chemical
Product number
28285
Product name
Mc-Val-Cit-PAB
Packaging
1mg
Price
$34
Updated
2024/03/01
More
Less

MC-Val-Cit-PAB Chemical Properties,Usage,Production

Description

MC-Val-Cit-PAB-OH is a cleavable peptide linker. The Val-Cit was designed to be cleaved specifically by Cathepsin B. MC group is reactive with thiol moiety

Uses

N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide is used as a reagent to prepare antibody-drug conjugates, which are compounds that selectively deliver cytotoxic drugs to a tumour-associated antigen.

MC-Val-Cit-PAB Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

MC-Val-Cit-PAB Suppliers

Americas 1 China 165 Europe 1 India 1 Japan 1 United States 11 Global 180
More
Less

View Lastest Price from MC-Val-Cit-PAB manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
MC-Val-Cit-PAB-OH 159857-80-4
Price
US $0.00/g
Min. Order
1g
Purity
>98.00%
Supply Ability
1g
Release date
2024-03-29
Career Henan Chemical Co
Product
N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide 159857-80-4
Price
US $6.68/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg-1000kg
Release date
2020-01-08

159857-80-4, MC-Val-Cit-PABRelated Search:

FMoc-Val-Cit-PAB-PNP Val-cit-PAB-OH pyrene-2,7-diyldiboronic acid Fmoc-Val-Cit-OH FMoc-Val-Cit-PAB

  • MC-Val-it-PAB
  • N-[(2S)-1-[[(2S)-5-(carbamoylamino)-1-[4-(hydroxymethyl)anilino]-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-6-(2,5-dioxopyrrol-1-yl)hexanamide
  • N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide
  • L-OrnithinaMide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aMinocarbonyl)-N-[4-(hydroxyMethyl)phenyl]-
  • 6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)hexanamide
  • ML-Val-Cit-PAB
  • MC-Val-Cit-PAB, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-
  • MC-Val-Cit-PAB
  • EOS-60616
  • MC-Val-Cit-PAB-OH
  • N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymeth
  • 6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-[(S)-1-[[(S)-1-[[4-(hydroxymethyl)phenyl]amino]-1-oxo-5-ureidopentan-2-yl]amino]-3-methyl-1-ox
  • N-[6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]-L-valyl-N5-carbamoyl-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide
  • 6-(2,5-Dioxo-2,5-dihydro-1-pyrrolyl)-N-[(S)-1-[[(S)-1-[[4-(hydroxymethyl)phenyl]amino]-1-oxo-5-ureido-2-pentyl]amino]-3-methyl-1-oxo-2-butyl]hexanamide
  • N-[6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]-L-valyl-N<sup>5</sup>-carbamoyl-N<sup>2</sup>-[4-(hydroxymethyl)phenyl]-L-ornithinamide
  • Benzenemethanol,2-chloro-8-nitro-
  • MC-Val-Cit-PAB (ADC peptide linker)
  • 6-(2,5-dioxopyrrol-1-yl)-N-[(1S)-1-[[(1S)-1-[[4-(hydroxymethyl)phenyl]carbamoyl]-4-ureido-butyl]carbamoyl]-2-methyl-propyl]hexanamide
  • MC-Val-Cit-PAB/MC-VC-PAB-OH
  • 159857-80-4
  • 59857-80-4
  • C28H40N6O7
  • ADCs
  • ADC Linker
  • ADC-Linker
  • ADC-Linkers