Ganetespib

Product Name: Ganetespib
CAS No.: 888216-25-9
Chemical Name: Ganetespib
Synonyms: CS-654;SAT9090;STA-9090;Ganetespib;STA-9090;STA9090;Ganetespib, >=98%;STA-9090/Ganetespib;Ganetespib USP/EP/BP;Ganetespib (STA-9090);STA-9090; STA 9090; STA9090
CBNumber: CB02566762
Molecular Formula: C20H20N4O3
Formula Weight: 364.4
MOL File: 888216-25-9.mol

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Ganetespib Property

Density: 1.39
storage temp.: -20°C
solubility: Soluble in DMSO (up to at least 25 mg/ml)
form: solid
pka: 7.38±0.20(Predicted)
color: White
Stability:: Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19432
Product name: Ganetespib
Purity: ≥98%
Packaging: 1mg
Price: $49
Updated: 2021/12/16

Cayman Chemical

Product number: 19432
Product name: Ganetespib
Purity: ≥98%
Packaging: 5mg
Price: $196
Updated: 2021/12/16

Cayman Chemical

Product number: 19432
Product name: Ganetespib
Purity: ≥98%
Packaging: 10mg
Price: $294
Updated: 2021/12/16

Cayman Chemical

Product number: 19432
Product name: Ganetespib
Purity: ≥98%
Packaging: 25mg
Price: $674
Updated: 2021/12/16

ChemScene

Product number: CS-0697
Product name: Ganetespib
Purity: 99.94%
Packaging: 5mg
Price: $70
Updated: 2021/12/16

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Ganetespib Chemical Properties,Usage,Production

Description

Ganetespib, also known as STA-9090, is a unique resorcinolic triazolone inhibitor of Hsp90, which is currently in clinical trials for a number of human cancers. It has shown promise in preclinical tests against various cancers, including lung cancer, prostate cancer, and leukemia. Moreover, It has also shown strong activity toward breast cancer, non-small cell lung cancer, gastric cancer, and acute myeloid leukemia.

Definition

ChEBI: Ganetespib is a member of triazoles and a ring assembly. It is a synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity.

General Description

A synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Ganetespib binds to and inhibits Hsp90, resulting in the proteasomal degradation of oncogenic client proteins, the inhibition of cell proliferation and the elevation of heat shock protein 72 (Hsp72); it may inhibit the activity of multiple kinases, such as c-Kit, EGFR, and Bcr-Abl, which as client proteins depend on functional HsP90 for maintenance. Hsp90, a 90 kDa molecular chaperone upregulated in a variety of tumor cells, plays a key role in the conformational maturation, stability and function of "client" proteins within the cell, many of which are involved in signal transduction, cell cycle regulation and apoptosis, including kinases, transcription factors and hormone receptors. Hsp72 exhibits anti-apoptotic functions; its up-regulation may be used as a surrogate marker for Hsp90 inhibition.

target

HSP90

References

Ganetespib (STA-9090), a Nongeldanamycin HSP90 Inhibitor, Has Potent Antitumor Activity in In Vitro and In Vivo Models of Non–Small Cell Lung Cancer DOI:10.1158/1078-0432.CCR-11-2967
https://www.cancer.gov/publications/dictionaries/cancer-drug/def/ganetespib
Ganetespib, a unique triazolone-containing Hsp90 inhibitor, exhibits potent antitumor activity and a superior safety profile for cancer therapy DOI: 10.1158/1535-7163.MCT-11-0755
Role of Ganetespib, an HSP90 Inhibitor, in Cancer Therapy: From Molecular Mechanisms to Clinical Practice doi: 10.3390/ijms24055014
A first in human, safety, pharmacokinetics, and clinical activity phase I study of once weekly administration of the Hsp90 inhibitor ganetespib (STA-9090) in patients with solid malignancies DOI:10.1186/1471-2407-13-152
Ganetespib synergizes with cyclophosphamide to improve survival of mice with autochthonous tumors in a mutant p53-dependent manner DOI:10.1038/cddis.2017.108

Ganetespib Preparation Products And Raw materials

Raw materials

Preparation Products

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Ganetespib Suppliers

China 119 India 3 United Kingdom 2 United States 19 Global 143

MedChemexpress LLC

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Aladdin Scientific

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Santa Cruz Biotechnology, Inc.

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View Lastest Price from Ganetespib manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Ganetespib 888216-25-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Ganetespib 888216-25-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

Career Henan Chemical Co

Product: GANETESPIB 888216-25-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95-99%
Supply Ability: 500kg/month
Release date: 2019-08-01

888216-25-9, GanetespibRelated Search:

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5-[2,4-Dihydroxy-5-(1-methylethyl)phenyl]-2,4-dihydro-4-(1-methyl-1H-indol-5-yl)-3H-1,2,4-triazol-3-one

Ganetespib (STA-9090)

3H-1,2,4-Triazol-3-one, 5-[2,4-dihydroxy-5-(1-Methylethyl)phenyl]-2,4-dihydro-4-(1-Methyl-1H-indol-5-yl)-

SAT9090

2,4-Dihydro-5-[2,4-dihydroxy-5-isopropylphenyl]-4-(1-methyl-1H-indol-5-yl)-3H-1,2,4-triazol-3-one

5-{1,5-Dihydro-3-[2,4-dihydroxy-5-(prop-2-yl)phenyl]-5-oxo-4H-1,2,4-triazol-4-yl}-1-methyl-1H-indole, 4-[4,5-Dihydro-4-(1-methyl-1H-indol-5-yl)-5-oxo-1H-1,2,4-triazol-3-yl]-6-(prop-2-yl)benzene-1,3-di ol

5-(2,4-dihydroxy-5-isopropylphenyl)-4-(1-methyl-1H-indol-5-yl)-2H-1,2,4-triazol-3(4H)-one

STA-9090/Ganetespib

STA9090; STA 9090; STA-9090; GANETESPIB

STA-9090; STA 9090; STA9090

CS-654

3-[2,4-Dihydroxy-5-(propan-2-yl)phenyl]-4-(1-methyl-1H-indol-5-yl)-4,5-dihydro-1H-1,2,4-triazol-5-one

5-[2,4-Dihydroxy-5-(1-methylethyl)phenyl]-2,4-dihydro-4-(1-methyl-1H-indol-5-yl)-3H-1,2,4-triazol-3-one Ganete

ganetespib (Hsp90 inhibitor)

3-(2,4-Dihydroxy-5-isopropylphenyl)-4-(1-methyl-1H-indol-5-yl)-1H-1,2,4-triazol-5(4H)-one

STA-9090;STA9090

GANETESPIB (STA-9090);STA-9090;STA 9090;STA9090

5-[2,4-Dihydroxy-5-(1-methylethyl)phenyl]-2,4-dihydro-4-(1-methyl-1H-indol-5-yl)-3H-1,2,4-tria

Ganetespib, >=98%

Ganetespib

STA-9090

3-(2,4-Dihydroxy-5-isopropylphenyl)-4-(1-methylindol-5-yl)-5-hydroxy-4H-1,2,4-triazole

Ganetespib USP/EP/BP

(5Z)-5-(4-hydroxy-6-oxo-3-propan-2-ylcyclohexa-2,4-dien-1-ylidene)-4-(1-methylindol-5-yl)-1,2,4-triazolidin-3-one

888216-25-9

Inhibitors