(S)-3-Amino-1-N-Boc-piperidine

Product Name: (S)-3-Amino-1-N-Boc-piperidine
CAS No.: 625471-18-3
Chemical Name: (S)-3-Amino-1-N-Boc-piperidine
Synonyms: S-1-BOC-3-aminopiperdine;(S)-1-BOC-3-PIPERIDINAMINE;(S)-1-BOC-3-AMINOPIPERIDINE;(S)-1-BOC-3-AMNIOPIPERIDINE;(S)-N-BOC-3-AMINOPIPERIDINE;(S)-3-AMINO-1-BOC-PIPERIDINE;(S)-3-AMino-1-Boc-piperid...;(S)-3-AMINO-N-TBOC-PIPERIDINE;（S）-3-Amino-1-N-Boc-pieridine;(S)-3-AMINO-1-N-BOC-PIPERIDINE
CBNumber: CB0258317
Molecular Formula: C10H20N2O2
Formula Weight: 200.28
MOL File: 625471-18-3.mol

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(S)-3-Amino-1-N-Boc-piperidine Property

alpha: -28.5 º (c=1, DMF)
Boiling point:: 277.3±33.0 °C(Predicted)
Density: 1.02
refractive index: 1.4690-1.4730
Flash point:: 122℃
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: Soluble in dimethylsulfoxide.
pka: 10.35±0.20(Predicted)
form: Gum or Semi-Solid
color: Colorless to yellow
optical activity: [α]/D +32.0±3°, c = 1 in DMF
Sensitive: Air Sensitive
InChI: InChI=1S/C10H20N2O2/c1-10(2,3)14-9(13)12-6-4-5-8(11)7-12/h8H,4-7,11H2,1-3H3/t8-/m0/s1
InChIKey: AKQXKEBCONUWCL-QMMMGPOBSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCC[C@H](N)C1
CAS DataBase Reference: 625471-18-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26
RIDADR: 2735
WGK Germany: 3
F: 10-34
HazardClass: 8
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 19929
Product name: (S)-(+)-3-Amino-1-Boc-piperidine
Purity: ≥98.0% (TLC)
Packaging: 1g
Price: $90.7
Updated: 2025/07/31

TCI Chemical

Product number: A2335
Product name: (S)-3-Amino-1-tert-butoxycarbonylpiperidine
Purity: >95.0%(GC)(T)
Packaging: 1g
Price: $149
Updated: 2025/07/31

TRC

Product number: S960110
Product name: (S)-tert-Butyl3-Aminopiperidine-1-carboxylate
Packaging: 100mg
Price: $70
Updated: 2021/12/16

Activate Scientific

Product number: AS12152-A
Product name: (S)-1-Boc-3-aminopiperidine
Purity: 98+% ee
Packaging: 5G
Price: $68
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB37134
Product name: (S)-1-Boc-3-aminopiperidine
Packaging: 5G
Price: $100
Updated: 2021/12/16

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(S)-3-Amino-1-N-Boc-piperidine Chemical Properties,Usage,Production

Chemical Properties

Light yellow liquid

Uses

(S)-(+)-3-Amino-1-Boc-piperidine is used to prepare selective noncovalent inhibitors of the bacterial cysteine protease IdeS. The product obtained by the reductive elimination reaction with ethylglyoxalte is used as a reference compound, which is used to determine the absolute configuration of the two enantiomers.

Synthesis

1271240-70-0

625471-18-3

General procedure for the synthesis of (S)-1-Boc-3-aminopiperidine from the compound (CAS:1271240-70-0): the azido derivative 42a (6.77 g, 29.9 mmol) was mixed with Pd/C catalyst (150 mg) in ethanol (200 mL) and subjected to a hydrogenation reaction at atmospheric pressure overnight. Upon completion of the reaction, the catalyst was removed by diatomaceous earth filtration followed by evaporation of the solvent. The product 43a was obtained as a colorless liquid in 90% yield (5.39 g, 26.9 mmol) without further purification. The 1H NMR, 13C NMR and IR spectral data of the product were in agreement with those reported in the literature30 . High-resolution mass spectrometry (HRMS, ESI) analysis showed a calculated and measured value of 201.1598 for C10H21O2N2 ([M + H]+); the specific spin [α]D20 was +26.0 (c 0.308, EtOH).

References

[1] Tetrahedron, 2011, vol. 67, # 7, p. 1485 - 1500
[2] Patent: WO2005/305, 2005, A1. Location in patent: Page 60
[3] Patent: WO2005/20976, 2005, A2. Location in patent: Page/Page column 239
[4] Patent: WO2005/60949, 2005, A2. Location in patent: Page/Page column 238

(S)-3-Amino-1-N-Boc-piperidine Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-3-Amino-1-N-Boc-piperidine Suppliers

Americas 1 Canada 1 China 248 Europe 4 Germany 3 India 3 Japan 2 Switzerland 1 United Kingdom 12 United States 48 Global 323

Sichuan Argalbio Technology Co,.Ltd

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View Lastest Price from (S)-3-Amino-1-N-Boc-piperidine manufacturers

Hangzhou ICH Biofarm Co., Ltd

Product: (S)-1-N-Boc-3-aminopiperidine 625471-18-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99.0%
Supply Ability: 20 tons
Release date: 2023-06-27

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: (S)-3-Amino-1-N-Boc-piperidine 625471-18-3
Price: US $7.90/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10kg
Release date: 2021-09-24

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: (S)-3-Amino-1-N-Boc-piperidine 625471-18-3
Price: US $7.90/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 10KG
Release date: 2021-09-24

625471-18-3, (S)-3-Amino-1-N-Boc-piperidineRelated Search:

4-AMINO-1-BOC-PIPERIDINE HYDROCHLORIDE N-BOC-3-Aminopiperidine DL-3-AMINO-1-N-BOC-PIPERIDINE (S)-3-Amino-1-N-Boc-piperidine (S)-3-AMINO-1-(TERT-BUTOXYCARBONYL)PIPERIDINE-3-CARBOXYLIC ACID 4-AMINO-1-N-BOC-PIPERIDINE (R)-3-AMINO-1-N-BOC-PIPERIDINE,(R)-3-Amino-1-N-Boc-Piperidine (R)-1-Boc-3-Aminopiperidine,(R)-3-AMINO-1-BOC-PIPERIDINE HYDROCHLORIDE 3-AMINOPIPERIDINE (S)-3-Aminopiperidine (S)-1-Boc-3-(Cbz-amino)-piperidine (S)-tert-Butyl 3-(methylsulfonamido)piperidine-1-carboxylate (1S,4S)-2-BOC-2,5-DIAZABICYCLO[2.2.2]OCTANE HYDROCHLORIDE (S)-1-BOC-3-N-(PYRIDIN-4-YLMETHYL)-AMINO-PIPERIDINE R-3-Dimethylamino-N-Boc-piperidine (1S,4S)-2-BOC-2,5-DIAZABICYCLO(2.2.2)OCTANE 1-N-Boc-3-(S)-Methylamino-piperidine 3-N-CBZ-AMINO-3-(3'-BOC)PIPERIDINE-PROPIONIC ACID S-3-(Carbamylamino)-N-Boc-piperidine

(S)-1-BOC-3-PIPERIDINAMINE

(S)-1-BOC-3-AMINOPIPERIDINE

(S)-1-BOC-3-AMINOPIPERIDINE HYDROCHLORIDE

(S)-1-BOC-3-AMNIOPIPERIDINE

(S)-3-AMINO-1-BOC-PIPERIDINE

(S)-3-AMINO-1-BOC-PIPERIDINE HYDROCHLORIDE

(S)-3-AMINO-1-N-BOC-PIPERIDINE

(S)-3-AMINO-N-TBOC-PIPERIDINE

(S)-3-AMINO-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

TERT-BUTYL (S)-3-AMINO-1-PIPERIDINECARBOXYLATE

(S)-N-BOC-3-AMINOPIPERIDINE

(S)-TERT-BUTYL 3-AMINOPIPERIDINE-1-CARBOXYLATE

(S)-TERT-BUTYL 3-AMINOPIPERIDINE-CARBOXYLATE

(S)-(-)-1-N-Boc-3-aminopiperidine

1-Piperidinecarboxylicacid,3-amino-,1,1-dimethylethylester,(3S)-(9CI)

1-PIPERIDINECARBOXYLIC ACID, 3-AMINO-, 1,1-DIMETHYLETHYL ESTER, (3S)-

tert-Butyl (3S)-3-aminopiperidine-1-carboxylate

tert-butyl 3-aminopiperidine-1-carboxylate (as citrate salt)

(S)-3-Aminopiperidine, N1-BOC protected

(S)-1-Boc-3-piperidinamine, tert-Butyl (S)-3-amino-1-piperidinecarboxylate

(S)-(-)-3-Amino-1-Boc-piperidi

S-1-BOC-3-aminopiperdine

(S)-3-Amino-1-N-Boc-piperidine ,98%

(3S)-3-Aminopiperidine, N1-BOC protected

(S)-3-AMino-1-tert-butoxycarbonylpiperidine

tert-Butyl (3S)-3-aminopiperidine-1-carboxylate, (3S)-3-Amino-1-(tert-butoxycarbonyl)piperidine

tert-Butyl (S)-3-aMino-4-piperidinecarboxylate

tert-Butyl (S)-3-aMino-2-piperidinecarboxylate

tert-Butyl (S)-3-aMino-3-piperidinecarboxylate

tert-Butyl (S)-3-aMino-5-piperidinecarboxylate

tert-Butyl (S)-3-aMino-6-piperidinecarboxylate

(S)-1-Boc-3-AMinopiperidine citric acid salt

(S)-3-Amino-1-Boc-piperidine tert-Butyl 3-Amino-1-piperidinecarboxylate

(S)-3-AMino-1-Boc-piperid...

(S)-t-butyl 3-aMinopiperidine-1-carboxylate

(S)-(+)-3-Amino-1-Boc-piperidine,97%

(S)-1-tert-Butoxycarbonyl-3-aminopiperidine

(S)-1-Boc-3-aminopiperidine,99%e.e.

(S)-3-Amino-1-tert-butoxycarbonylpiperidine &gt

(S)-3-aminopiperidine-1-carboxylate

(S)-tert-Butyl 3-Amino-1-piperidinecarboxylate

(S)-3-Amino-1-N-Boc-piperidine USP/EP/BP

tert-Butyl(S)-3-aminopiperidine-1-carboxylate

(S)-tert-Butyl 3-amino-piperidin-1-carboxylate

（S）-3-Amino-1-N-Boc-pieridine

(<i>S</i>)-(+)-3-Amino-1-Boc-piperidine

S-3-amino-1-N-Boc-piperidine 98%

625471-18-3

625471-18-8

625471-18-4

625471-18-6

625471-18-5

625471-18-7

pharmacetical

Amines

Pyrans, Piperidines &Piperazines

Piperidine

Piperidine Series