(R)-1-Boc-3-Aminopiperidine

Product Name: (R)-1-Boc-3-Aminopiperidine
CAS No.: 188111-79-7
Chemical Name: (R)-1-Boc-3-Aminopiperidine
Synonyms: tert-butyl (R)-3-aminopiperidine-1-carboxylate;(R)-TERT-BUTYL 3-AMINOPIPERIDINE-1-CARBOXYLATE;tert-Butyl (3R)-3-aminopiperidine-1-carboxylate;(R)-3-AMINO-1-N-BOC-PIPERIDINE;LigliptinImpurity69;(R)-BOC-PIP(3-NH2) HCL;Linagliptin Impurity 69;Linagliptin Impurity 98;(R)-1-BOC-3-PIPERIDINAMINE;(R)-1-Boc-3-AMinopiperidin
CBNumber: CB7326716
Molecular Formula: C10H20N2O2
Formula Weight: 200.28
MOL File: 188111-79-7.mol

More

Less

(R)-1-Boc-3-Aminopiperidine Property

alpha: 28.5 º (c=1, DMF)
Boiling point:: 277.3±33.0 °C(Predicted)
Density: 1.041±0.06 g/cm3(Predicted)
refractive index: 1.4730
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: Chloroform (Slightly), DMF (Slightly), DMSO (Slightly)
pka: 10.35±0.20(Predicted)
form: Liquid
color: Colorless to pale yellow
optical activity: [α]/D -28.5±2°, c = 1 in DMF
Water Solubility: Immiscible with water.
Sensitive: Moisture Sensitive
InChI: InChI=1S/C10H20N2O2/c1-10(2,3)14-9(13)12-6-4-5-8(11)7-12/h8H,4-7,11H2,1-3H3/t8-/m1/s1
InChIKey: AKQXKEBCONUWCL-MRVPVSSYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCC[C@@H](N)C1
CAS DataBase Reference: 188111-79-7(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26
RIDADR: UN2735
WGK Germany: 3
F: 10-34
HazardClass: 8
PackingGroup: III
HS Code: 29333990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 07858
Product name: (R)-(−)-3-Amino-1-Boc-piperidine
Purity: ≥98.0% (TLC)
Packaging: 1g
Price: $292
Updated: 2025/07/31

Sigma-Aldrich

Product number: 07858
Product name: (R)-(−)-3-Amino-1-Boc-piperidine
Purity: ≥98.0% (TLC)
Packaging: 1G-F
Price: $283
Updated: 2024/03/01

TRC

Product number: B692215
Product name: tert-Butyl(R)-3-Aminopiperidine-1-carboxylate
Packaging: 1g
Price: $150
Updated: 2021/12/16

Chem-Impex

Product number: 16109
Product name: (R)-1-Boc-3-aminopiperidine,99%(HPLC,Chiralpurity)
Purity: 99%(HPLC,Chiralpurity)
Packaging: 1G
Price: $13.44
Updated: 2021/12/16

Activate Scientific

Product number: AS2214
Product name: (R)-(1-Boc)-3-aminopiperidine
Purity: 97+% ee
Packaging: 1g
Price: $19
Updated: 2021/12/16

More

Less

(R)-1-Boc-3-Aminopiperidine Chemical Properties,Usage,Production

Chemical Properties

Yellow liquid

Uses

(R)-3-Amino-1-Boc-piperidine can be used to prepare a benzoxazepine derivative named (R)-7-(3,5-dimethoxyphenyl)-N-(piperidin-3-yl)-4-propionyl-2,3,4,5-tetrahydro-1,4-benzoxazepine-9-carboxamide, a potent CBP/P300 bromodomain inhibitor.

Uses

(R)-(-)-3-Amino-1-Boc-piperidine(tert-Butyl (R)-3-Aminopiperidine-1-carboxylate), is an heterocyclic building block used for the synthesis of more complex pharmaceutical compounds. It is also found to act as a γ-secretase modulators, and a potent structure for lowering Ab42 production in both in vitro and in vivo.

General Description

(R)-3-Amino-1-Boc-piperidine can be used as a precursor for the preparation of dipeptidyl peptidase IV inhibitors like linagliptin, alogliptin, and other antidiabetic agents.

Synthesis

915226-43-6

188111-79-7

The general procedure for the synthesis of (R)-1- tert-butyl tert-butyloxycarbonyl-3-aminopiperidine from (R)-3-carbamoylpiperidine-1-carboxylic acid is as follows: in Example 28, (R)-1-(tert-butoxycarbonyl)-3-aminopiperidine was prepared as follows: firstly, (R)-1-(tert-butoxycarbonyl)piperidine amide (9 g of a solution, wherein the net weight of (R)-1 -(tert-butoxycarbonyl)piperidine amide is 0.7 g), sodium hydroxide (1.3 g, 10 equiv) and sodium hypochlorite aqueous solution (2.2 g, 10 equiv) are combined. Oxycarbonyl)piperidinamide has a net weight of 0.7 g), sodium hydroxide (1.3 g, 10 eq.) and aqueous sodium hypochlorite (2.2 g, 1.1 eq.) were mixed. The reaction mixture was stirred at 15 to 25°C for 16 hours. Upon completion of the reaction, the aqueous layer was separated and removed, followed by evaporation of the solvent under reduced pressure. Toluene (10 mL) and saturated brine (5 mL) were added to the residue and the aqueous layer was again separated and removed. Finally, the solvent was evaporated under reduced pressure to afford (R)-1-tert-butoxycarbonyl-3-aminopiperidine, the product was a yellow oil (0.7 g, net weight: 0.5 g, yield: 80%).

References

[1] Patent: US2010/105917, 2010, A1. Location in patent: Page/Page column 21

(R)-1-Boc-3-Aminopiperidine Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

(R)-1-Boc-3-Aminopiperidine Suppliers

Canada 1 China 308 Europe 3 France 2 Germany 8 India 6 Japan 3 Switzerland 2 United Kingdom 16 United States 60 Global 409

Ningbo Enzyme Chemical Co., LTD

Tel: 0574-+86-574-8773-0716-654-654 18042089573
Email: yufang.jiang@enzymaster.com
Country: China
ProdList: 46
Advantage: 58

Chengdu Firster Pharmaceutical Co., Ltd.

Tel: 028-87078428 028-87074958
Fax: 8772-8116
Email: chengzhenyong@cdfirster.com
Country: China
ProdList: 2598
Advantage: 60

Chengdu Aminotp Pharmaceutical Technology Co.,Ltd.

Tel: 028-85755578 18140172005
Fax: 028-85755578
Email: sales@aminotp.com
Country: China
ProdList: 298
Advantage: 58

Shanghai NAIFU Biotechnology Co., Ltd

Tel: 18939876937 18939876937;
Email: sales@naifuchem.com
Country: China
ProdList: 49
Advantage: 58

Chemyouth Life Science（Suzhou）Co.,Ltd

Tel: 13752065514
Email: jianwei@chemyouth.com
Country: China
ProdList: 133
Advantage: 58

Chengdu Firster Pharmaceutical Co., Ltd.

Tel: 19138996873
Email: 670603485@qq.com
Country: China
ProdList: 172
Advantage: 58

Nanjing Tianyuexing Bio-tech Co.,Ltd.

Tel: 15305186370
Email: david@chicopharm.com
Country: China
ProdList: 318
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

More

Less

View Lastest Price from (R)-1-Boc-3-Aminopiperidine manufacturers

Xingtai Haoxun Import and Export Trade Co., Ltd.

Product: (R)-1-Boc-3-Aminopiperidine 188111-79-7
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10tons
Release date: 2020-07-17

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: (R)-1-Boc-3-Aminopiperidine 188111-79-7
Price: US $100.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2021-09-14

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: tert-butyl (3R)-3-aminopiperidine-1-carboxylate 188111-79-7
Price: US $100.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 10KG
Release date: 2021-09-17

188111-79-7, (R)-1-Boc-3-AminopiperidineRelated Search:

tert-Butyl carbazate N-Carbobenzyloxyglycine tert-Butanol 6-Aminocaproic acid Glycine Haloperidol 3-AMINOPIPERIDINE ALTRENOGEST 8-Bromo-3-methyl-xanthine 2-Aminoacetophenone (R)-Boc-Nipecotic acid Tris(hydroxymethyl)aminomethane Diphenoxylate 1-Piperidinecarboxylic acid, 3-[[(phenylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester, (3R)- 1,1'-Diacetylferrocene (R)-1-Boc-3-Aminopiperidine-3-carboxylic acid (R)-1-N-BOC-3-METHYLAMINO PIPERIDINE Piperidine

tert-Butyl (3R)-3-aminopiperidine-1-carboxylate

(R)-3-Aminopiperidine, N1-BOC protected

(R)-1-t-Butyloxycarbonyl-3-aminopiperidine hydrochloride

(R)-1-Boc-3-piperidinamine, tert-Butyl (R)-3-amino-1-piperidinecarboxylate

(R)-3-Amino-1-N-Boc-Piperidine (R)-1-Boc-3-Aminopiperidine

1-TERT-BUTYLOXYCARBONYL-3-R-AMINOPIPERIDINE HYDROCHLORIDE

1-Piperidinecarboxylicacid,3-amino-,1,1-dimethylethylester,(3R)-(9CI)

(R)-3-AMINO-N-BOC-PIPERIDINE

(R)-3-AMINO-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

(R)-3-AMINO-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER HCL

(R)-1-TERT-BUTYLOXYCARBONYL-3-AMINOPIPERIDINE HYDROCHLORIDE

(R)-1-BOC-3-PIPERIDINAMINE

(R)-1-BOC-3-AMNIOPIPERIDINE

(R)-1-BOC-3-AMINOPIPERIDINE

(R)-1-BOC-3-AMINOPIPERIDINE HCL

(R)-1-N-BOC-3-AMINO PIPERIDINE

(R)-N-BOC-3-AMINOPIPERIDINE

(R)-TERT-BUTYL 3-AMINOPIPERIDINE-1-CARBOXYLATE

TERT-BUTYL (R)-3-AMINO-1-PIPERIDINECARBOXYLATE

2-Methyl-2-propanyl (3S)-3-amino-1-piperidinecarboxylate

(3R)-3-Aminopiperidine, N1-BOC protected

(3R)-3-Amino-N1-Boc-piperidine

(R)-1-Boc-3-aMinopiperidi...

(R)-1-Boc-3-AMinopiperidin

tert-Butyl (3R)-3-aminopiperidine-1-carboxylate, (3R)-3-Amino-1-(tert-butoxycarbonyl)piperidine

(R)-1-Boc-3-AMniopiperidine SynonyMs (R)-3-AMino-1-N-Boc-piperidine

(R)-tert-Butyl 3-aMinopiperidine-1-carboxylate, >95%

(R)-(-)-3-Amino-1-Boc-piperidine,98%

tert-butyl (R)-3-aminopiperidine-1-carboxylate

(R)-1-Boc-3-aminopiperidine,99%e.e.

1-T-BUTYLOXYCARBONYL-3-R-AMINOPIPERIDINE HYDROCHLORIDE

1-tert-butyloxycarbonyl-3-r-aminopiperidine

1-PIPERIDINECARBOXYLIC ACID, 3-AMINO-, 1,1-DIMETHYLETHYL ESTER, (3R)-

(R)-BOC-PIP(3-NH2) HCL

(R)-3-AMINO-1-N-BOC-PIPERIDINE

(R)-3-AMINO-1-BOC-PIPERIDINE

(R)-3-AMINO-1-BOC-PIPERIDINE HYDROCHLORIDE

(R)-1-tert-butoxycarbonyl-3-aminoperidol

3-aminopiperidine-1-carboxyL

Linagliptin Impurity 69

Linagliptin N-t-BOC Piperidine Impurity

Linagliptin Impurity 98

(R)-3-aminopiperidine-1-carboxylate

ert-butyl(3R)-3-aminopiperidine-1-carboxylate

(R)-1-Boc-3-Aminopiperidine USP/EP/BP

LigliptinImpurity69

(R)-tert-Butyl 3-amino-piperidin-1-carboxylate

(<i>R</i>)-(?)-3-Amino-1-Boc-piperidine

(R)-1-tert-Butyloxycarbonyl-3-aminopiperidine

188111-79-7

1152113-32-0

1118-90-1

C10H21ClN2O2

CHIRAL CHEMICALS

Piperidines

Piperidine Series

pharmacetical

Piperidine