ChemicalBook > CAS DataBase List > Y 11

Y 11

Product Name
Y 11
CAS No.
1086639-59-9
Chemical Name
Y 11
Synonyms
Y 11;NSC206142;1-(2-Hydroxyethyl)-3,5,7-triaza-1-azaniatricyclo[3.3.1.13,7]decane bromide;1-(2-Hydroxyethyl)-3,5,7-triaza-1-azoniatricyclo[3.3.1.13,7]decane BroMide;3,5,7-Triaza-1-azoniatricyclo[3.3.1.13,7]decane, 1-(2-hydroxyethyl)-, broMide
CBNumber
CB02603010
Molecular Formula
C8H17BrN4O
Formula Weight
265.15078
MOL File
1086639-59-9.mol
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Y 11 Property

storage temp. 
-20°C
solubility 
H2O: soluble25mg/mL, clear
form 
powder
color 
white to beige
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
36/37/39
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0968
Product name
Y11
Purity
≥98% (HPLC)
Packaging
5mg
Price
$94.6
Updated
2022/05/15
Cayman Chemical
Product number
18521
Product name
Y11
Purity
≥95%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
18521
Product name
Y11
Purity
≥95%
Packaging
5mg
Price
$87
Updated
2024/03/01
Cayman Chemical
Product number
18521
Product name
Y11
Purity
≥95%
Packaging
10mg
Price
$151
Updated
2024/03/01
Cayman Chemical
Product number
18521
Product name
Y11
Purity
≥95%
Packaging
25mg
Price
$321
Updated
2024/03/01
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Y 11 Chemical Properties,Usage,Production

Uses

Focal adhesion kinases (FAKs) are non-receptor tyrosine kinases that play roles in regulating diverse processes, including cell adhesion, spreading, migration, proliferation, and apoptosis. They are over-expressed in many types of cancer. Y11 inhibits FAK1 autophosphorylation by blocking phosphorylation of Y397. At 100 μM, it was shown to decrease cell viability of T47D breast cancer and C8161 melanoma cell lines.[Cayman Chemical]

Uses

Y 11 is a potent inhibitor of focal adhesion kinase (FAK); Y 11 prevents FAK autophosphorylation at the Y397 site (IC50 ~ 50 nM in an in vitro kinase assay). Displays selectivity for FAK over a panel of other kinases (concentration used in assay = 1 μM). Y 11 decreases cell viability in a number of cancer cell lines; blocks colony formation in SW620 and BT474 cell lines.

Y 11 Preparation Products And Raw materials

Raw materials

Preparation Products

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Y 11 Suppliers

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1086639-59-9, Y 11Related Search:

Y16 1,2,4,5-BENZENETETRAMINE TETRAHYDROCHLORIDE

  • Y 11
  • 3,5,7-Triaza-1-azoniatricyclo[3.3.1.13,7]decane, 1-(2-hydroxyethyl)-, broMide
  • 1-(2-Hydroxyethyl)-3,5,7-triaza-1-azoniatricyclo[3.3.1.13,7]decane BroMide
  • NSC206142
  • 1-(2-Hydroxyethyl)-3,5,7-triaza-1-azaniatricyclo[3.3.1.13,7]decane bromide
  • 1086639-59-9
  • C8H17N4OBr