Y 11
- Product Name
- Y 11
- CAS No.
- 1086639-59-9
- Chemical Name
- Y 11
- Synonyms
- Y 11;NSC206142;1-(2-Hydroxyethyl)-3,5,7-triaza-1-azaniatricyclo[3.3.1.13,7]decane bromide;1-(2-Hydroxyethyl)-3,5,7-triaza-1-azoniatricyclo[3.3.1.13,7]decane BroMide;3,5,7-Triaza-1-azoniatricyclo[3.3.1.13,7]decane, 1-(2-hydroxyethyl)-, broMide
- CBNumber
- CB02603010
- Molecular Formula
- C8H17BrN4O
- Formula Weight
- 265.15078
- MOL File
- 1086639-59-9.mol
Y 11 Property
- storage temp.
- -20°C
- solubility
- H2O: soluble25mg/mL, clear
- form
- powder
- color
- white to beige
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML0968
- Product name
- Y11
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $94.6
- Updated
- 2022/05/15
- Product number
- 18521
- Product name
- Y11
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 18521
- Product name
- Y11
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $87
- Updated
- 2024/03/01
- Product number
- 18521
- Product name
- Y11
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $151
- Updated
- 2024/03/01
- Product number
- 18521
- Product name
- Y11
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $321
- Updated
- 2024/03/01
Y 11 Chemical Properties,Usage,Production
Uses
Focal adhesion kinases (FAKs) are non-receptor tyrosine kinases that play roles in regulating diverse processes, including cell adhesion, spreading, migration, proliferation, and apoptosis. They are over-expressed in many types of cancer. Y11 inhibits FAK1 autophosphorylation by blocking phosphorylation of Y397. At 100 μM, it was shown to decrease cell viability of T47D breast cancer and C8161 melanoma cell lines.[Cayman Chemical]
Uses
Y 11 is a potent inhibitor of focal adhesion kinase (FAK); Y 11 prevents FAK autophosphorylation at the Y397 site (IC50 ~ 50 nM in an in vitro kinase assay). Displays selectivity for FAK over a panel of other kinases (concentration used in assay = 1 μM). Y 11 decreases cell viability in a number of cancer cell lines; blocks colony formation in SW620 and BT474 cell lines.