CH5132799

Product Name: CH5132799
CAS No.: 1007207-67-1
Chemical Name: CH5132799
Synonyms: CS-541;100843;CS-1068;CH5132799;CH5132799 (PA-799);CH5132799 USP/EP/BP;CH5132799 CH-5132799;CH5132799;CH 5132799;CH-5132799;5-(7-methylsulfonyl-2-morpholin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl)pyrimidin-2-amine;5-(7-(Methylsulfonyl)-2-morpholino-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrimidin-2-ami
CBNumber: CB02621133
Molecular Formula: C15H19N7O3S
Formula Weight: 377.42
MOL File: 1007207-67-1.mol

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CH5132799 Property

Boiling point:: 751.1±70.0 °C(Predicted)
Density: 1.58
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Powder
pka: 3.96±0.20(Predicted)
color: White to gray

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 26410
Product name: CH5132799
Packaging: 25mg
Price: $788
Updated: 2024/03/01

Cayman Chemical

Product number: 26410
Product name: CH5132799
Packaging: 50mg
Price: $1082
Updated: 2024/03/01

Cayman Chemical

Product number: 26410
Product name: CH5132799
Packaging: 5mg
Price: $198
Updated: 2024/03/01

Cayman Chemical

Product number: 26410
Product name: CH5132799
Packaging: 10mg
Price: $355
Updated: 2024/03/01

TRC

Product number: C291700
Product name: CH5132799
Packaging: 5mg
Price: $220
Updated: 2021/12/16

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CH5132799 Chemical Properties,Usage,Production

Uses

CH5132799 is a selective class I phosphoinositide 3-kinase (PI3K) inhibitor that targets human cancers harboring oncogenic PIK3CA mutations. CH5132799 also showed potent antiproliferative and antitumor activity.

Biological Activity

ch5132799 is an inhibitor of class i phosphatidylinositol 3-kinase (pi3k) with ic50 value of 14nm against pi3kα [1].ch5132799 shows inhibitory effect on class i pi3k with ic50 values of 0.014μm, 0.12μm, 0.5μm and 0.036μm against pi3kα, pi3kβ, pi3kδ and pi3kγ, respectively. pi3kα is especially sensitive to ch5132799. ch5132799 is a selective inhibitor. it shows less effect on class ii pi3ks, class iii pi3k and mtor. for other 26 protein kinases, ch5132799 nearly has no inhibition with ic50 value of > 10μm. ch5132799 is found to have potent antitumor activity. it exerts ic50 values of 0.2μm, 0.032μm, 0.056μm and 0.12μm in hct116, kpl-4, t-47d and sk-ov-3 cell lines, respectively. moreover, ch5132799 is oral available in animal models. treatment of ch5132799 shows strong tumor regression at dose of 12.5 mg/kg in mice bearing human breast cancer xenografts [1].

target

PI3Kα

References

[1] ohwada j, ebiike h, kawada h, et al. discovery and biological activity of a novel class i pi3k inhibitor, ch5132799. bioorganic & medicinal chemistry letters, 2011, 21(6): 1767-1772.

CH5132799 Preparation Products And Raw materials

Raw materials

Preparation Products

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CH5132799 Suppliers

China 94 India 2 United Kingdom 1 United States 18 Global 115

Shanghai Tachizaki Biomedical Research Center

Tel: 18014399201
Email: sales@chemlab-tachizaki.com
Country: China
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Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
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Jinan Trio PharmaTech Co., Ltd.

Tel: +86 (531) 88811783
Fax: +86 (531) 55696010 QQ 1762738062
Email: sales@trio-pharmatech.com (International market)
Country: China
ProdList: 1856
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Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: meilunui@163.com
Country: China
ProdList: 4727
Advantage: 58

Wuhan TCASChem Technology Co., Ltd.

Tel: 027-027-86697669 13986148687
Fax: 86-027-86697669
Email: sales@tcaschem.com
Country: China
ProdList: 3889
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NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
Country: China
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Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
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SYN|thesis med chem P/L

Tel: +86-021-50720296
Fax: +86-021-50720297
Email: service@synkinase.com
Country: China
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Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-400-6206333 18521732826
Fax: 021-50323701
Email: market@aladdin-e.com
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MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
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Country: United States
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1007207-67-1, CH5132799Related Search:

MK-2206 2HCl BAY 80-6946 (Copanlisib) Alpelisib (BYL719) Pictilisib PF-04691502 BEZ235 (NVP-BEZ235, Dactolisib)

CH5132799

CH5132799,5-(7-(Methylsulfonyl)-2-Morpholino-6,7-dihydro-5H-pyrrolo[2,3-d]pyriMidin-4-yl)pyriMidin-2-aMine

[5-[7-Methylsulfonyl-2-(morpholin-4-yl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl]pyrimidin-2-yl]amine

5-(7-(Methylsulfonyl)-2-Morpholino-6,7-dihydro-5H-pyrrolo[2,3-d]pyriMidin-4-yl)pyriMidin-2-aMine

[5-[7-Methylsulfonyl-2-(morpholin-4-yl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl]pyrimidin-2-yl]amine CH5132799

CH5132799;CH 5132799;CH-5132799

5-(7-(Methylsulfonyl)-2-morpholino-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrimidin-2-ami

CS-541

CS-1068

100843

5-(7-methylsulfonyl-2-morpholin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl)pyrimidin-2-amine

2-Pyrimidinamine, 5-[6,7-dihydro-7-(methylsulfonyl)-2-(4-morpholinyl)-5H-pyrrolo[2,3-d]pyrimidin-4-yl]-

CH5132799 (PA-799)

CH5132799 USP/EP/BP

CH5132799 CH-5132799

1007207-67-1

Inhibitors

PI3K/Akt/mTOR

JAK

STAT

Akt

mTOR

PI3K