CH5132799
- Product Name
- CH5132799
- CAS No.
- 1007207-67-1
- Chemical Name
- CH5132799
- Synonyms
- CS-541;100843;CS-1068;CH5132799;CH5132799 (PA-799);CH5132799 USP/EP/BP;CH5132799 CH-5132799;CH5132799;CH 5132799;CH-5132799;5-(7-methylsulfonyl-2-morpholin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl)pyrimidin-2-amine;5-(7-(Methylsulfonyl)-2-morpholino-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrimidin-2-ami
- CBNumber
- CB02621133
- Molecular Formula
- C15H19N7O3S
- Formula Weight
- 377.42
- MOL File
- 1007207-67-1.mol
CH5132799 Property
- Boiling point:
- 751.1±70.0 °C(Predicted)
- Density
- 1.58
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Powder
- pka
- 3.96±0.20(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 26410
- Product name
- CH5132799
- Packaging
- 25mg
- Price
- $788
- Updated
- 2024/03/01
- Product number
- 26410
- Product name
- CH5132799
- Packaging
- 50mg
- Price
- $1082
- Updated
- 2024/03/01
- Product number
- 26410
- Product name
- CH5132799
- Packaging
- 5mg
- Price
- $198
- Updated
- 2024/03/01
- Product number
- 26410
- Product name
- CH5132799
- Packaging
- 10mg
- Price
- $355
- Updated
- 2024/03/01
- Product number
- C291700
- Product name
- CH5132799
- Packaging
- 5mg
- Price
- $220
- Updated
- 2021/12/16
CH5132799 Chemical Properties,Usage,Production
Uses
CH5132799 is a selective class I phosphoinositide 3-kinase (PI3K) inhibitor that targets human cancers harboring oncogenic PIK3CA mutations. CH5132799 also showed potent antiproliferative and antitumor activity.
Biological Activity
ch5132799 is an inhibitor of class i phosphatidylinositol 3-kinase (pi3k) with ic50 value of 14nm against pi3kα [1].ch5132799 shows inhibitory effect on class i pi3k with ic50 values of 0.014μm, 0.12μm, 0.5μm and 0.036μm against pi3kα, pi3kβ, pi3kδ and pi3kγ, respectively. pi3kα is especially sensitive to ch5132799. ch5132799 is a selective inhibitor. it shows less effect on class ii pi3ks, class iii pi3k and mtor. for other 26 protein kinases, ch5132799 nearly has no inhibition with ic50 value of > 10μm. ch5132799 is found to have potent antitumor activity. it exerts ic50 values of 0.2μm, 0.032μm, 0.056μm and 0.12μm in hct116, kpl-4, t-47d and sk-ov-3 cell lines, respectively. moreover, ch5132799 is oral available in animal models. treatment of ch5132799 shows strong tumor regression at dose of 12.5 mg/kg in mice bearing human breast cancer xenografts [1].
target
PI3Kα
References
[1] ohwada j, ebiike h, kawada h, et al. discovery and biological activity of a novel class i pi3k inhibitor, ch5132799. bioorganic & medicinal chemistry letters, 2011, 21(6): 1767-1772.