Tributyltin chloride Property

Melting point:

-9 °C

Boiling point:

171-173 °C25 mm Hg(lit.)

Density 

1.2 g/mL at 25 °C(lit.)

vapor pressure 

<0.01 mm Hg ( 20 °C)

refractive index 

n20/D 1.492(lit.)

Flash point:

>230 °F

storage temp. 

2-8°C

solubility 

0.017g/l

form 

liquid

Specific Gravity

1.186

color 

colorless

Water Solubility 

PRACTICALLY INSOLUBLE

Sensitive 

Moisture Sensitive

BRN 

3535715

Exposure limits

ACGIH: TWA 0.1 mg/m3; STEL 0.2 mg/m3 (Skin)
NIOSH: IDLH 25 mg/m3; TWA 0.1 mg/m3

Stability:

Hygroscopic

InChIKey

GCTFWCDSFPMHHS-UHFFFAOYSA-M

LogP

2.21 at 23℃

CAS DataBase Reference

1461-22-9(CAS DataBase Reference)

NIST Chemistry Reference

Tri-n-butyltin chloride(1461-22-9)

EPA Substance Registry System

Tributyltin chloride (1461-22-9)

Safety

Hazard Codes 

T,N

Risk Statements 

21-25-36/38-48/23/25-50/53

Safety Statements 

35-36/37/39-45-60-61-26

RIDADR 

UN 2788 6.1/PG 3

WGK Germany 

3

RTECS 

WH6820000

F 

3-9-21

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

II

HS Code 

29310095

Hazardous Substances Data

1461-22-9(Hazardous Substances Data)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H312Harmful in contact with skin

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H372Causes damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Tributyltin chloride Chemical Properties,Usage,Production

Description

Tributyltin chloride is also as Chlorotributyltin, is the chloride of tributyltin. It is a biocide that contaminates foods, especially shellfish. It is an endocrine disrupter in several marine species and is neurotoxic and immuno-toxic in mammals. It has been used as a heat stabilizer, agricultural pesticide and component of antifouling paints². However, it is perhaps the most acutely toxic chemical to aquatic organisms ever deliberately introduced to water. It has been demonstrated to have an adverse effect on shellfish in France and England, and as a consequence the use of tributyltin‐containing antifouling paints has been restricted in these countries. Other countries have banned the use of tributyltin‐containing antifouling paints or are contemplating restrictions³.

References

1. Cooke, G. M., et al. Food & Chemical Toxicology An International Journal Published for the British Industrial Biological Research Association 42.2(2004):211-220.
2. Nakatsu, Yusuke, Y. Kotake, and S. Ohta. "Tributyltin-induced cell death is mediated by calpain in PC12 cells."Neurotoxicology 27.4(2006):587-593.
3. Maguire, R. James. "Environmental aspects of tributyltin." Applied Organometallic Chemistry 1.6(1987):475-498.

Chemical Properties

Colorless or light yellow clear liquid. Soluble in the common organic solvents; including alcohol, heptane, benzene, and toluene; insoluble in cold water, but hydrolyzes in hot water.

Uses

Tributyltin Chloride is a triorganotin compound with insecticidal acitivity. It is an endocrine disruptor as well as an inhibitor for the V-ATPases (potential targets in the treatmen t of diseases such as osteoporosis and cancer). Tributyltin Chloride has the functions of antiseptic, sterilization and mildew proof and widely used in wood preservation, ship paint, etc. Further, it is used in hot end glass coating and rodent-repellent for cable coatings.

Preparation

Tributyltin chloride is prepared by a redistribution reaction by combining stannic chloride and tetrabutyltin:
3 (C4H9)4Sn + SnCl4 → 4 (C4H9)3SnCl.

Definition

ChEBI: Tributyltin chloride is an inorganic molecular entity.

Hazard

A poison by ingestion and skin contact. A severe eye irritant. Tributyl tin compounds are extremely toxic to marine life.

Flammability and Explosibility

Not classified

Toxicology

Tributyltin chloride (TBTCL) is a widely used biocide and heat stabiliser for PVC compositions. TBTCL has been detected in humans and may cause harmful effects on the thyroid, cardiovascular and other organs in humans. It is also an endocrine disruptor with toxic effects on the male reproductive system.TBTCL causes apoptosis and cell cycle arrest. Activation of endoplasmic reticulum stress and inhibition of autophagy are responsible for TBTCL-induced apoptosis and cell cycle arrest.