5-R-Rivaroxaban
- Product Name
- 5-R-Rivaroxaban
- CAS No.
- 865479-71-6
- Chemical Name
- 5-R-Rivaroxaban
- Synonyms
- R-Rivaroxaban;Rivaroxaban A;Rivaroxaban-6;ent-Rivaroxaban;5-R-Rivaroxaban;XARELTO; BAY 59-7939;Rivaroxaban R-Isomer;Rivaroxyban R-isomer;Rivaroxaban isomer F;R-Rivaroxaban Impurity
- CBNumber
- CB02624033
- Molecular Formula
- C19H18ClN3O5S
- Formula Weight
- 435.88
- MOL File
- 865479-71-6.mol
5-R-Rivaroxaban Property
- Melting point:
- >227°C (dec.)
- Boiling point:
- 732.6±60.0 °C(Predicted)
- Density
- 1.460
- storage temp.
- Refrigerator
- solubility
- Acetonitrile (Slightly, Heated, Sonicated), DMSO (Slightly, Sonicated), Methanol
- form
- Solid
- pka
- 13.36±0.46(Predicted)
- color
- White to Off-White
N-Bromosuccinimide Price
- Product number
- R538005
- Product name
- ent-Rivaroxaban
- Packaging
- 25mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- 448268
- Product name
- ent-Rivaroxaban
- Packaging
- 10mg
- Price
- $368
- Updated
- 2021/12/16
- Product number
- CS-0730
- Product name
- 5-R-Rivaroxaban
- Purity
- 99.72%
- Packaging
- 50mg
- Price
- $370
- Updated
- 2021/12/16
- Product number
- A3126
- Product name
- 5-R-Rivaroxaban
- Packaging
- 50mg
- Price
- $370
- Updated
- 2021/12/16
- Product number
- 98910
- Product name
- ent-Rivaroxaban
- Packaging
- 1mg
- Price
- $385
- Updated
- 2021/12/16
5-R-Rivaroxaban Chemical Properties,Usage,Production
Uses
ent-Rivaroxaban is the R-isomer of Rivaroxaban (R538000), which is a novel antithrombotic agent. A highly potent and selective, direct FXa inhibitor.
Biological Activity
5-r-rivaroxaban is a selective inhibitor of human factor xa with ic50 value of 0.7 nmol/l [1].factor xa is a serine endopeptidase enzyme and plays an important role in the convergence point of the intrinsic and extrinsic pathways in blood coagulation system [2].5-r-rivaroxaban is an oral, direct factor xa inhibitor and the inhibition is species-dependent. when tested with purified factoe xa from human or rabbit, 5-r-rivaroxaban showed similar affinity with ic50 value of 0.7 nmol/l and 0.8 nmol/l, respectively, while had a ic50 value as low as 3.4 nmol/l when tested with rat factor xa [1].pre-treated anaesthetised rat model with intravenous 5-r-rivaroxaban at a dose of 2 mg/kg, and after bleeding initiated intravenous treated with rfviia (100/400 μg/kg), pcc (25/50 u/kg) or apcc (50/100 u/kg), the result showed that 5-r-rivaroxaban pre-treatment significantly shorten bleeding time and clotting time compared with 5-r-rivaroxaban alone treated group [2]. similar results were obtained when tested with rabbit model [1].it has been reported that 5-r-rivaroxaban is a promising drug for atrial fibrillation, venous thromboembolism or thromboembolic disorders in clinic [3] [4] [1].
References
[1]. perzborn, e., et al., rivaroxaban: a new oral factor xa inhibitor. arterioscler thromb vasc biol, 2010. 30(3): p. 376-81.
[2]. perzborn, e., et al., reversal of rivaroxaban anticoagulation by haemostatic agents in rats and primates. thromb haemost, 2013. 110(1): p. 162-72.
[3]. beyer-westendorf, j., et al., efficacy and safety of rivaroxaban or fondaparinux thromboprophylaxis in major orthopedic surgery: findings from the ortho-tep registry. j thromb haemost, 2012. 10(10): p. 2045-52.
[4]. palareti, g., et al., clinical management of rivaroxaban-treated patients. expert opin pharmacother, 2013. 14(5): p. 655-67.
5-R-Rivaroxaban Preparation Products And Raw materials
Raw materials
Preparation Products
5-R-Rivaroxaban Suppliers
- Tel
- --
- Fax
- --
- sales@carbosynth.com
- Country
- United Kingdom
- ProdList
- 6005
- Advantage
- 58
View Lastest Price from 5-R-Rivaroxaban manufacturers
- Product
- 5-R-Rivaroxaban 865479-71-6
- Price
- US $8.00-2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-25