5-R-Rivaroxaban

Product Name: 5-R-Rivaroxaban
CAS No.: 865479-71-6
Chemical Name: 5-R-Rivaroxaban
Synonyms: R-Rivaroxaban;Rivaroxaban A;Rivaroxaban-6;ent-Rivaroxaban;5-R-Rivaroxaban;XARELTO; BAY 59-7939;Rivaroxaban R-Isomer;Rivaroxyban R-isomer;Rivaroxaban isomer F;R-Rivaroxaban Impurity
CBNumber: CB02624033
Molecular Formula: C19H18ClN3O5S
Formula Weight: 435.88
MOL File: 865479-71-6.mol

More

Less

5-R-Rivaroxaban Property

Melting point:: >227°C (dec.)
Boiling point:: 732.6±60.0 °C(Predicted)
Density: 1.460
storage temp.: Refrigerator
solubility: Acetonitrile (Slightly, Heated, Sonicated), DMSO (Slightly, Sonicated), Methanol
form: Solid
pka: 13.36±0.46(Predicted)
color: White to Off-White

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

TRC

Product number: R538005
Product name: ent-Rivaroxaban
Packaging: 25mg
Price: $180
Updated: 2021/12/16

Usbiological

Product number: 448268
Product name: ent-Rivaroxaban
Packaging: 10mg
Price: $368
Updated: 2021/12/16

ChemScene

Product number: CS-0730
Product name: 5-R-Rivaroxaban
Purity: 99.72%
Packaging: 50mg
Price: $370
Updated: 2021/12/16

ApexBio Technology

Product number: A3126
Product name: 5-R-Rivaroxaban
Packaging: 50mg
Price: $370
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 98910
Product name: ent-Rivaroxaban
Packaging: 1mg
Price: $385
Updated: 2021/12/16

More

Less

5-R-Rivaroxaban Chemical Properties,Usage,Production

Uses

ent-Rivaroxaban is the R-isomer of Rivaroxaban (R538000), which is a novel antithrombotic agent. A highly potent and selective, direct FXa inhibitor.

Biological Activity

5-r-rivaroxaban is a selective inhibitor of human factor xa with ic50 value of 0.7 nmol/l [1].factor xa is a serine endopeptidase enzyme and plays an important role in the convergence point of the intrinsic and extrinsic pathways in blood coagulation system [2].5-r-rivaroxaban is an oral, direct factor xa inhibitor and the inhibition is species-dependent. when tested with purified factoe xa from human or rabbit, 5-r-rivaroxaban showed similar affinity with ic50 value of 0.7 nmol/l and 0.8 nmol/l, respectively, while had a ic50 value as low as 3.4 nmol/l when tested with rat factor xa [1].pre-treated anaesthetised rat model with intravenous 5-r-rivaroxaban at a dose of 2 mg/kg, and after bleeding initiated intravenous treated with rfviia (100/400 μg/kg), pcc (25/50 u/kg) or apcc (50/100 u/kg), the result showed that 5-r-rivaroxaban pre-treatment significantly shorten bleeding time and clotting time compared with 5-r-rivaroxaban alone treated group [2]. similar results were obtained when tested with rabbit model [1].it has been reported that 5-r-rivaroxaban is a promising drug for atrial fibrillation, venous thromboembolism or thromboembolic disorders in clinic [3] [4] [1].

References

[1]. perzborn, e., et al., rivaroxaban: a new oral factor xa inhibitor. arterioscler thromb vasc biol, 2010. 30(3): p. 376-81.
[2]. perzborn, e., et al., reversal of rivaroxaban anticoagulation by haemostatic agents in rats and primates. thromb haemost, 2013. 110(1): p. 162-72.
[3]. beyer-westendorf, j., et al., efficacy and safety of rivaroxaban or fondaparinux thromboprophylaxis in major orthopedic surgery: findings from the ortho-tep registry. j thromb haemost, 2012. 10(10): p. 2045-52.
[4]. palareti, g., et al., clinical management of rivaroxaban-treated patients. expert opin pharmacother, 2013. 14(5): p. 655-67.

5-R-Rivaroxaban Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

5-R-Rivaroxaban Suppliers

Canada 1 China 112 India 9 United Kingdom 1 United States 17 Global 140

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32165
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Standardpharm Co. Ltd.

Tel: 86-714-3992388
Email: overseasales1@yongstandards.com
Country: United States
ProdList: 14332
Advantage: 58

BOC Sciences

Tel: +1-631-485-4226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
Country: United States
ProdList: 19553
Advantage: 58

Cato Research Chemicals Inc.

Tel: 020-81215950 4000-868-328
Email: customer@uwalab.com
Country: United States
ProdList: 10404
Advantage: 58

TargetMol Chemicals Inc.

Tel: +8613564774135
Email: zijue.cai@tsbiochem.com
Country: United States
ProdList: 19885
Advantage: 58

TargetMol Chemicals Inc.

Tel
Email: support@targetmol.com
Country: United States
ProdList: 38632
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

ApexBio Technology

Tel: --
Fax: --
Email: sales@apexbt.com
Country: United States
ProdList: 6251
Advantage: 58

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

United States Biological

Tel: --
Fax: --
Email: chemicals@usbio.net
Country: United States
ProdList: 6214
Advantage: 80

Creative Enzymes

Tel: --
Fax: --
Email: info@creative-enzymes.com
Country: United States
ProdList: 6057
Advantage: 58

Combi-Blocks Inc.

Tel: --
Fax: --
Email: sales@combi-blocks.com
Country: United States
ProdList: 6618
Advantage: 69

Fragmenta

Tel: --
Fax: --
Email: sales@fragmenta.com
Country: United States
ProdList: 1068
Advantage: 0

More

Less

View Lastest Price from 5-R-Rivaroxaban manufacturers

Henan Fengda Chemical Co., Ltd

Product: 5-R-Rivaroxaban 865479-71-6
Price: US $8.00-2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-25

865479-71-6, 5-R-RivaroxabanRelated Search:

4-(3-nitrophenyl)-3-Morpholinone 3-Morpholinone, 4-phenyl- 3-MORPHOLINONE, 4-[4-[(5S)-5-(AMINOMETHYL)-2-OXO-3-OXAZOLIDINYL]PHENYL]- Palbociclib Impurity 21 3'-N-DesMethyl-3'-N-tosyl AzithroMycin [[p-(2-methoxyethyl)phenoxy]methyl]oxirane 1,2-BenzenedicarboxaMide, N1,N2-bis[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]- 1H-ISOINDOLE-1,3(2H)-DIONE, 2-[[(5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL)PHENYL]-5-OXAZOLIDINYL]METHYL]- Rivaroxaban (S)-4,5-dichloro-N-((2-oxo-3-(4-(3-oxoMorpholino)phenyl)oxazolidin-5-yl)Methyl)thiophene-2-carboxaMide Urea, N,N'-bis[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]- AcetaMide, N-[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]- 2-ThiophenecarboxaMide, N-[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]- 5-Methyl-2-thiophenecarboxylic acid 5-chloro-N-(4-((S)-5-((5-chlorothiophene-2-carboxamido)methyl)-2-oxooxazolidin-3-yl)phenyl)-N-(2-(2-oxo-2-((((S)-2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)amino)ethoxy)ethyl)thiophene-2-carboxamide 3,5-dichlorothiophene-2-carboxylic acid Rivaroxaban Impurity H 1H-Benzotriazole, 1-hydroxy-, sodium salt

5-R-Rivaroxaban

5-Chloro-N-[[(5R)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-2-thiophenecarboxamide

R-Rivaroxaban

(R)-5-chloro-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)thiophene-2-carboxamide

ent-Rivaroxaban

Rivaroxaban R-Isomer Impurity

(R)-Rivaroxaban, ent-Rivaroxaban

Rivaroxaban R-Isomer

Rivaroxaban Impurity 6(Rivaroxaban R-Isomer)

(S)-4-(4-(5-(((2-methyl-4-oxopentan-2-yl)amino)methyl)-2- oxooxazolidin-3-yl)phenyl)morpholin-3-one

XARELTO; BAY 59-7939

Rivaroxaban impurity H: 5-R Rivaroxaban

Rivaroxaban A

2-Thiophenecarboxamide, 5-chloro-N-[[(5R)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-

Rivaroxaban impurity 7/5-R-Rivaroxaban/ent-Rivaroxaban/5-Chloro-N-[[(5R)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-2-thiophenecarboxamide

Rivaroxaban-6

R-Rivaroxaban Impurity

Rivaroxaban R-Isomer (ent-Rivaroxaban)

Rivaroxaban EP Impurity A/Rivaroxaban R-isomer Impurity

Rivaroxyban R-isomer

R-ENANTIOMER OF RIVAROXABAN

Rivaroxaban Impurities364

Rivaroxaban EP Impurity A

5-Chloro-N-[[(5R)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl]thiophene-2-carboxamide

Rivaroxaban Enantiomer (R-Isomer)

R-Isomer of Rivaroxaban

Rivaroxaban isomer F

865479-71-6