4-CHLORO-2,5-DIFLUOROBENZONITRILE

Product Name: 4-CHLORO-2,5-DIFLUOROBENZONITRILE
CAS No.: 135748-35-5
Chemical Name: 4-CHLORO-2,5-DIFLUOROBENZONITRILE
Synonyms: 4-CHLORO-2,5-DIFLUOROBENZONITRILE;2, 5-difluoro-4-chlorobenzonitrile;Benzonitrile, 4-chloro-2,5-difluoro-
CBNumber: CB0262525
Molecular Formula: C7H2ClF2N
Formula Weight: 173.55
MOL File: 135748-35-5.mol

More

Less

4-CHLORO-2,5-DIFLUOROBENZONITRILE Property

Boiling point:: 206.8±35.0 °C(Predicted)
Density: 1.43±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
Appearance: White to off-white Solid
InChI: InChI=1S/C7H2ClF2N/c8-5-2-6(9)4(3-11)1-7(5)10/h1-2H
InChIKey: OMVDTUXOHXQKML-UHFFFAOYSA-N
SMILES: C(#N)C1=CC(F)=C(Cl)C=C1F
CAS DataBase Reference: 135748-35-5(CAS DataBase Reference)

More

Less

Safety

HS Code: 2926907090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

TRC

Product number: T775673
Product name: 4-Chloro-2,5-difluorobenzonitrile
Packaging: 50mg
Price: $45
Updated: 2021/12/16

ChemScene

Product number: CS-0063913
Product name: 4-Chloro-2,5-difluorobenzonitrile
Purity: 97.87%
Packaging: 1g
Price: $62
Updated: 2021/12/16

ChemScene

Product number: CS-0063913
Product name: 4-Chloro-2,5-difluorobenzonitrile
Purity: 97.87%
Packaging: 10g
Price: $328
Updated: 2021/12/16

AK Scientific

Product number: 6381AA
Product name: 4-Chloro-2,5-difluorobenzonitrile
Packaging: 5g
Price: $331
Updated: 2021/12/16

Apolloscientific

Product number: PC902770
Product name: 4-Chloro-2,5-difluorobenzonitrile
Purity: 95%
Packaging: 5g
Price: $409
Updated: 2021/12/16

More

Less

4-CHLORO-2,5-DIFLUOROBENZONITRILE Chemical Properties,Usage,Production

Uses

4-Chloro-2,5-difluorobenzonitrile is an organic compound that is often used as an intermediate in organic synthesis. It can participate in a variety of reactions and can also be used to prepare other organic compounds.

Synthesis

508203-26-7

135748-35-5

The general procedure for the synthesis of 4-chloro-2,5-difluorobenzonitrile from 4-chloro-2,5-difluorobenzamide was as follows: a mixture of 4-bromo-2,5-difluorobenzoic acid (11a, 53.28 g), thionyl chloride (165 mL), and N,N-dimethylformamide (DMF, 0.87 mL) was stirred for 1.5 hr at 80 °C, and subsequently cooled to room temperature. The reaction mixture was concentrated under reduced pressure and the resulting residue was dissolved in chloroform (300 mL). To this solution, 28 wt% ammonia (300 mL) was slowly added dropwise at 5 °C and stirred for 0.5 h at the same temperature. After completion of the reaction, the mixture was extracted with chloroform, the organic layers were combined and dried over anhydrous sodium sulfate. The desiccant was removed by filtration and the filtrate was concentrated under reduced pressure to give a pale yellow solid. The solid was mixed with phosphoryl chloride (195 mL) and stirred at 80 °C for 2 h. After completion of the reaction it was cooled to room temperature. The reaction mixture was concentrated under reduced pressure and the residue was treated with ether (500 mL) and ice water (300 mL) followed by stirring for 0.5 h at room temperature. The mixture was extracted with ether and the organic layer was washed sequentially with saturated aqueous sodium bicarbonate and brine, then dried over anhydrous sodium sulfate. The desiccant was removed by filtration and the filtrate was concentrated under reduced pressure to afford the target product 4-chloro-2,5-difluorobenzonitrile (9h, 41.57 g, 85% yield) as a light yellow solid.

References

[1] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 17, p. 5235 - 5246

4-CHLORO-2,5-DIFLUOROBENZONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

4-CHLORO-2,5-DIFLUOROBENZONITRILE Suppliers

China 117 Germany 1 India 1 United Kingdom 4 United States 19 Global 142

Accela ChemBio Inc.

Tel: +1-858-6993322
Fax: (+1)-858-876-1948
Email: info@accelachem.com
Country: United States
ProdList: 21193
Advantage: 58

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63687
Advantage: 58

Aladdin Scientific

Tel
Email: tp@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

Aceschem Inc.

Tel: +1-817863-6948 +1-（817）863-6948
Email: sales@aceschem.com
Country: United States
ProdList: 19632
Advantage: 58

Synthonix Inc

Tel: --
Fax: --
Email: info@synthonix.com
Country: United States
ProdList: 6872
Advantage: 58

Alfa Chemistry

Tel: --
Fax: --
Email: info@Alfa-Chemistry.com
Country: United States
ProdList: 6814
Advantage: 0

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6962
Advantage: 56

AlliChem, LLC

Tel: --
Fax: --
Email: sales@allichemllc.com
Country: United States
ProdList: 6516
Advantage: 60

Waterstone Technology, LLC

Tel: --
Fax: --
Email: sales@waterstonetech.com
Country: United States
ProdList: 6786
Advantage: 30

Combi-Blocks Inc.

Tel: --
Fax: --
Email: sales@combi-blocks.com
Country: United States
ProdList: 6618
Advantage: 69

SynQuest Laboratories, Inc.

Tel: --
Fax: --
Email: info@synquestlabs.com
Country: United States
ProdList: 6871
Advantage: 62

HONEST JOY HOLDINGS LIMITED

Tel: --
Fax: --
Email: sales@honestjoy.cn
Country: United States
ProdList: 6675
Advantage: 54

2A PharmaChem USA

Tel: --
Fax: --
Email: sales@2apharmachem.com
Country: United States
ProdList: 6137
Advantage: 39

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6718
Advantage: 47

APAC Pharmaceutical, LLC

Tel: --
Fax: --
Email: sales@apacpharma.com
Country: United States
ProdList: 6322
Advantage: 38

Beta Pharma, Inc.

Tel: --
Fax: --
Email: sales@betapharma.com
Country: United States
ProdList: 6226
Advantage: 60

ChemPacific Corporation

Tel: --
Fax: --
Email: sales@chempacific.com
Country: United States
ProdList: 6891
Advantage: 51

AcceleDev Chemical LLC

Tel: --
Fax: --
Email: info@acceledev.com
Country: United States
ProdList: 632
Advantage: 42

BOSCHE SCIENTIFIC, LLC

Tel: --
Fax: --
Email: Sales@BoscheSci.com
Country: United States
ProdList: 6477
Advantage: 55

More

Less

View Lastest Price from 4-CHLORO-2,5-DIFLUOROBENZONITRILE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4-CHLORO-2,5-DIFLUOROBENZONITRILE 135748-35-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Career Henan Chemical Co

Product: 4-CHLORO-2,5-DIFLUOROBENZONITRILE 135748-35-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg; 2kg；10kg; 100kg
Release date: 2019-08-30

135748-35-5, 4-CHLORO-2,5-DIFLUOROBENZONITRILERelated Search:

Ethyl maltol Hypophosphorous acid Imidacloprid BISMERTHIAZOL Ethyl nicotinate Benzonitrile 5-CHLORO-2,4-DIFLUOROBENZONITRILE 2,5-Difluorobenzonitrile 4-Chloro-2-fluorobenzonitrile 4-Chloro-3-fluorobenzonitrile 4-Chlorobenzonitrile 4-CHLORO-2,5-DIFLUOROBENZONITRILE 3-CHLORO-2,6-DIFLUOROBENZONITRILE 2-CHLORO-3,6-DIFLUOROBENZONITRILE 2-CHLORO-4,5-DIFLUOROBENZONITRILE,2-Chloro-4,5-difluorobenzonitrile 98%,2-Chloro-4,5-difluorobenzonitrile98% 4-CHLORO-2,6-DIFLUOROBENZONITRILE 3-CHLORO-2,4-DIFLUOROBENZONITRILE

Benzonitrile, 4-chloro-2,5-difluoro-

4-CHLORO-2,5-DIFLUOROBENZONITRILE

2, 5-difluoro-4-chlorobenzonitrile

135748-35-5

Fluorine series

Nitrile