ChemicalBook > CAS DataBase List > 2-BroMo-5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine

2-BroMo-5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine

Product Name
2-BroMo-5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine
CAS No.
143150-92-9
Chemical Name
2-BroMo-5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine
Synonyms
Edoxaban Impurity 64;2-Bromo-5-methyl-4H,6H,7H-[1,3]thiazolo[5,4-c]pyridine;2-bromo-5-methyl-4H,5H,6H,7H-[1,3]thiazolo[5,4-c]pyridine;2-BroMo-5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine;2-bromo-4,5,6,7-tetrahydro-5-methyl-Thiazolo[5,4-c]pyridine;2-bromo-5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine;Thiazolo[5,4-c]pyridine, 2-broMo-4,5,6,7-tetrahydro-5-Methyl-;2-BroMo-5-Methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine
CBNumber
CB02629588
Molecular Formula
C7H9BrN2S
Formula Weight
233.13
MOL File
143150-92-9.mol
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2-BroMo-5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine Property

Boiling point:
286.4±30.0 °C(Predicted)
Density 
1.594±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Acetonitrile (Slightly), Chloroform (Slightly)
pka
6.41±0.20(Predicted)
form 
Solid
color 
Grey
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B809005
Product name
2-bromo-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine
Packaging
100mg
Price
$75
Updated
2021/12/16
TRC
Product number
B809005
Product name
2-bromo-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine
Packaging
500mg
Price
$245
Updated
2021/12/16
AK Scientific
Product number
CS-0041774
Product name
2-Bromo-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine
Packaging
1g
Price
$93
Updated
2021/12/16
SynQuest Laboratories
Product number
7H70-9-15
Product name
2-Bromo-5-methyl-4H,6H,7H-[1,3]thiazolo[5,4-c]pyridine
Packaging
250mg
Price
$125
Updated
2021/12/16
SynQuest Laboratories
Product number
7H70-9-15
Product name
2-Bromo-5-methyl-4H,6H,7H-[1,3]thiazolo[5,4-c]pyridine
Packaging
1g
Price
$375
Updated
2021/12/16
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2-BroMo-5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine Chemical Properties,Usage,Production

Synthesis

17899-48-8

143150-92-9

5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-amine (12) (600.0 g, 3.545 mol) was used as a raw material and suspended in water (6.0 L). 48% hydrobromic acid (4.2 L) was added slowly and dropwise at 0 to 15 °C. Subsequently, a solution of sodium nitrite (367.2 g, 3.56 mol) in water (1.8 L) was added dropwise over 1.5 to 5 hours. After the dropwise addition, the reaction mixture was heated to 30°C and stirred continuously for 24 hours. After completion of the reaction, the reaction mixture was neutralized with 5N aqueous sodium hydroxide solution (6.0 L) to a strong base (pH = 12.5). Then, the aqueous layer was extracted with toluene (12.0 L and 6.0 L) in two batches. The toluene layers were combined and dried by adding anhydrous sodium sulfate (1202.0 g). After filtration to remove insoluble matter, the mother liquor was concentrated under reduced pressure at 40 °C to afford the target product 2-bromo-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine (11a) (557.6 g, 67.5% yield). The product was characterized by 1H-NMR (CDCl3): δppm 3.58-3.57 (t, 3H, J = 1.8Hz), 2.92-2.87 (m, 2H), 2.81-2.76 (m, 2H), 2.49 (s, 3H).

References

[1] Patent: US2013/144061, 2013, A1. Location in patent: Paragraph 0248; 0249; 0250
[2] Patent: EP1683800, 2006, A1. Location in patent: Page/Page column 56
[3] Patent: US2017/50983, 2017, A1. Location in patent: Paragraph 0142; 0143; 0144; 0145; 0146

2-BroMo-5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-BroMo-5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
2-Bromo-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine 143150-92-9
Price
US $2.00-6.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-07-30
WUHAN FORTUNA CHEMICAL CO., LTD
Product
2-Bromo-5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine 143150-92-9
Price
US $0.00/G
Min. Order
10G
Purity
98%min
Supply Ability
30kg/month
Release date
2023-01-29
Shaanxi Dideu New Materials Co. Ltd
Product
2-BroMo-5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine 143150-92-9
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-03-06

143150-92-9, 2-BroMo-5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridineRelated Search:

Polyacrylamide Chitosan Gelatin Edoxaban Impurity 45 Edoxaban Impurity 38 2-(((1S,2R,4S)-4-(dimethylcarbamoyl)-2-(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamido)cyclohexyl)amino)-2-oxoacetic acid carbamic acid, n-[(1r,2r,5s)-5-[(dimethylamino)carbonyl]-2-hydroxycyclohexyl]-, 1,1-dimethylethyl ester EthanediaMide, N1-(5-chlo... edoxaban (1S,3R,4S)-4-(2-((5-chloropyridin- 2-yl)amino)-2-oxoacetamido)-3-(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamido)cyclohexane-1-carboxylic acid (1R,2R,4S)-2-[(tert-butoxycarbonyl)aMino]-4-[(diMethylaMino)carbonyl]cyclohexyl Methanesulfonate tert-Butyl [(1R,2S,5S)-2-amino-5-[(dimethylamino)carbonyl]cyclohexyl]carbamate oxalate Ethyl 2-((5-chloropyridin-2-yl)amino)-2-oxoacetate hydrochloride (1R,3S,4R)-3-Amino-4-hydroxy-cyclohexanecarboxylic acid ethyl ester hydrochloride Edoxaban Impurity 37 Edoxaban Impurity 42 2-Amino-5-chloropyridine Clanfenur

  • 2-BroMo-5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine
  • Thiazolo[5,4-c]pyridine, 2-broMo-4,5,6,7-tetrahydro-5-Methyl-
  • 2-bromo-5-methyl-4H,5H,6H,7H-[1,3]thiazolo[5,4-c]pyridine
  • 2-bromo-4,5,6,7-tetrahydro-5-methyl-Thiazolo[5,4-c]pyridine
  • 2-bromo-5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine
  • 2-BroMo-5-Methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine
  • 2-Bromo-5-methyl-4H,6H,7H-[1,3]thiazolo[5,4-c]pyridine
  • Edoxaban Impurity 64
  • 143150-92-9