ChemicalBook > CAS DataBase List > Cabotegravir (GSK744, GSK1265744)

Cabotegravir (GSK744, GSK1265744)

Product Name
Cabotegravir (GSK744, GSK1265744)
CAS No.
1051375-10-0
Chemical Name
Cabotegravir (GSK744, GSK1265744)
Synonyms
Cabotegravir;GSK1265744;GSK744;CS-2197;Caboteve;Cabot wei;SureCN82803;S/GSK1265744;Cabotegravin;SK744, GSK1265744
CBNumber
CB02668664
Molecular Formula
C19H17F2N3O5
Formula Weight
405.35
MOL File
1051375-10-0.mol
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Cabotegravir (GSK744, GSK1265744) Property

Boiling point:
664.0±55.0 °C(Predicted)
Density 
1.57±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
insoluble in H2O; insoluble in EtOH; ≥19.35 mg/mL in DMSO with gentle warming
form 
solid
pka
4.50±1.00(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H400Very toxic to aquatic life

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
27215
Product name
GSK744
Packaging
5mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
27215
Product name
GSK744
Packaging
10mg
Price
$61
Updated
2024/03/01
Cayman Chemical
Product number
27215
Product name
GSK744
Packaging
25mg
Price
$131
Updated
2024/03/01
Cayman Chemical
Product number
27215
Product name
GSK744
Packaging
50mg
Price
$243
Updated
2024/03/01
TRC
Product number
C050100
Product name
Cabotegravir
Packaging
100mg
Price
$910
Updated
2021/12/16
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Cabotegravir (GSK744, GSK1265744) Chemical Properties,Usage,Production

Uses

Cabotegravir is a long acting HIV-1 integrase inhibitor with action against a broad range of HIV subtypes.

Definition

ChEBI: Cabotegravir is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of (3S,11aR)-6-hydroxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydro[1,3]oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxylic acid with the amino group of 2,4-difluorobenzylamine. Used (as its sodium salt) for treatment of HIV-1. It has a role as a HIV-1 integrase inhibitor. It is a difluorobenzene, a secondary carboxamide, a monocarboxylic acid amide and an organic heterotricyclic compound. It is a conjugate acid of a cabotegravir(1-).

Biological Activity

Cabotegravir (GSK744, GSK1265744) is a long-acting HIV integrase inhibitor against a broad range of HIV subtypes, inhibiting HIV-1 integrase-catalyzed strand transfer with IC50 of 3 nM. Phase 2.

Mechanism of action

Caboggravir is a potent inhibitor of HIV integrase, which prevents the HIV virus from infecting human cells, while rilpivirine prevents the virus from replicating itself.

target

HIV integrase

Cabotegravir (GSK744, GSK1265744) Preparation Products And Raw materials

Raw materials

Preparation Products

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Cabotegravir (GSK744, GSK1265744) Suppliers

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View Lastest Price from Cabotegravir (GSK744, GSK1265744) manufacturers

Guangzhou Tengyue Chemical Co., Ltd.
Product
Cabotegravir (GSK744, GSK1265744) 1051375-10-0
Price
US $240.00/g
Min. Order
10g
Purity
99% Purity (What/sapp: +86 18145728414)
Supply Ability
1000 Tons/Month
Release date
2023-11-16
Zhuozhou Wenxi import and Export Co., Ltd
Product
SureCN82803 1051375-10-0
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-26
Longyan Tianhua Biological Technology Co., Ltd
Product
Cabotegravir 1051375-10-0
Price
US $20.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000KG
Release date
2020-11-11

1051375-10-0, Cabotegravir (GSK744, GSK1265744)Related Search:

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  • (3S,11aR)-N-[(2,4-Difluorophenyl)methyl]-2,3,5,7,11,11a-hexahydro-6-hydroxy-3-methyl-5,7-dioxo-oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide
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  • S/GSK1265744
  • (3S,11AR)-N-(2,4-DIFLUOROBENZYL)-6-HYDROXY-3-METHYL-5,7-DIOXO-2,3,5,7,11,11A-HEXAHYDROOXAZOLO[3,2-A]PYRIDO[1,2-D]PYRAZINE-8-CARBOXAMIDE
  • Cabotegravir(GSK1265744A,GSK-744)
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  • (3S,11aR)-N-[(2,4-Difluorophenyl)methyl]-2,3,5,7,11,11a-hexa...
  • Cabotegravir 13CD5
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  • (3R,6S)-N-[(2,4-difluorophenyl)methyl]-10-hydroxy-6-methyl-8,11-dioxo-4-oxa-1,7-diazatricyclo[7.4.0.03,7]trideca-9,12-diene-12-carboxamide
  • 1051375-10-0
  • C19H17F2N3O5
  • Inhibitors