Cabotegravir (GSK744, GSK1265744)
- Product Name
- Cabotegravir (GSK744, GSK1265744)
- CAS No.
- 1051375-10-0
- Chemical Name
- Cabotegravir (GSK744, GSK1265744)
- Synonyms
- Cabotegravir;GSK1265744;GSK744;CS-2197;Cabotwe;Caboteve;Cabot wei;SureCN82803;S/GSK1265744;Cabotegravin
- CBNumber
- CB02668664
- Molecular Formula
- C19H17F2N3O5
- Formula Weight
- 405.35
- MOL File
- 1051375-10-0.mol
Cabotegravir (GSK744, GSK1265744) Property
- Boiling point:
- 664.0±55.0 °C(Predicted)
- Density
- 1.57±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- insoluble in H2O; insoluble in EtOH; ≥19.35 mg/mL in DMSO with gentle warming
- form
- solid
- pka
- 4.50±1.00(Predicted)
- color
- White to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H400Very toxic to aquatic life
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P273Avoid release to the environment.
P391Collect spillage. Hazardous to the aquatic environment
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 27215
- Product name
- GSK744
- Packaging
- 5mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 27215
- Product name
- GSK744
- Packaging
- 10mg
- Price
- $61
- Updated
- 2024/03/01
- Product number
- 27215
- Product name
- GSK744
- Packaging
- 25mg
- Price
- $131
- Updated
- 2024/03/01
- Product number
- 27215
- Product name
- GSK744
- Packaging
- 50mg
- Price
- $243
- Updated
- 2024/03/01
- Product number
- C050100
- Product name
- Cabotegravir
- Packaging
- 100mg
- Price
- $910
- Updated
- 2021/12/16
Cabotegravir (GSK744, GSK1265744) Chemical Properties,Usage,Production
Uses
Cabotegravir is a long acting HIV-1 integrase inhibitor with action against a broad range of HIV subtypes.
Definition
ChEBI: Cabotegravir is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of (3S,11aR)-6-hydroxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydro[1,3]oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxylic acid with the amino group of 2,4-difluorobenzylamine. Used (as its sodium salt) for treatment of HIV-1. It has a role as a HIV-1 integrase inhibitor. It is a difluorobenzene, a secondary carboxamide, a monocarboxylic acid amide and an organic heterotricyclic compound. It is a conjugate acid of a cabotegravir(1-).
Biological Activity
Cabotegravir (GSK744, GSK1265744) is a long-acting HIV integrase inhibitor against a broad range of HIV subtypes, inhibiting HIV-1 integrase-catalyzed strand transfer with IC50 of 3 nM. Phase 2.
Mechanism of action
Caboggravir is a potent inhibitor of HIV integrase, which prevents the HIV virus from infecting human cells, while rilpivirine prevents the virus from replicating itself.
target
HIV integrase
Cabotegravir (GSK744, GSK1265744) Preparation Products And Raw materials
Raw materials
Preparation Products
Cabotegravir (GSK744, GSK1265744) Suppliers
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- @pharmaffiliates.com
- Country
- India
- ProdList
- 6754
- Advantage
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- sales@ajchem.in
- Country
- India
- ProdList
- 6100
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View Lastest Price from Cabotegravir (GSK744, GSK1265744) manufacturers
- Product
- Cabotegravir (GSK744, GSK1265744) 1051375-10-0
- Price
- US $240.00/g
- Min. Order
- 10g
- Purity
- 99% Purity (What/sapp: +86 18145728414)
- Supply Ability
- 1000 Tons/Month
- Release date
- 2023-11-16
- Product
- SureCN82803 1051375-10-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-26
- Product
- Cabotegravir 1051375-10-0
- Price
- US $20.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000KG
- Release date
- 2020-11-11