Varenicline-d4
- Product Name
- Varenicline-d4
- CAS No.
- 2183239-01-0
- Chemical Name
- Varenicline-d4
- Synonyms
- Varenicline-d4;D4-Varenicline;Varenicline Nitroso D4;7,8,9,10-tetrahydro-6H-6,10-methanoazepino[4,5-g]quinoxaline-7,7,9,9-d4
- CBNumber
- CB02675994
- Molecular Formula
- C13H13N3
- Formula Weight
- 211.27
- MOL File
- 2183239-01-0.mol
Varenicline-d4 Property
- storage temp.
- Store at -20°C
- solubility
- Water: 0.0877 mg/mL
- form
- A solid
- Water Solubility
- Water: 0.0877 mg/mL
N-Bromosuccinimide Price
- Product number
- 26102
- Product name
- Varenicline-d4
- Purity
- ≥99% deuterated forms (d1-d4)
- Packaging
- 500μg
- Price
- $93
- Updated
- 2024/03/01
- Product number
- 26102
- Product name
- Varenicline-d4
- Purity
- ≥99% deuterated forms (d1-d4)
- Packaging
- 1mg
- Price
- $166
- Updated
- 2024/03/01
- Product number
- 5896DV
- Product name
- 13,13,15,15-Tetradeuterio-5,8,14-triazatetracyclo[10.3.1.02,11.04,9]hexadeca-2,4,6,8,10-pentaene
- Packaging
- 1mg
- Price
- $282
- Updated
- 2021/12/16
- Product number
- D37660
- Product name
- Varenicline-d4
- Packaging
- 1mg
- Price
- $490
- Updated
- 2021/12/16
Varenicline-d4 Chemical Properties,Usage,Production
Description
Varenicline-d4 is intended for use as an internal standard for the quantification of varenicline by GC- or LC-MS. Varenicline is a full agonist of α7 subunit-containing neuronal nicotinic acetylcholine receptors (nAChRs; EC50 = 18 μM) and a partial agonist of α4β2 subunit-containing nAChRs (EC50 = 2.3 μM). Formulations containing varenicline have been used as aids in smoking cessation.
Uses
Varenicline-d4 is deuterium labeled Varenicline. Varenicline (CP 526555) is a potent partial agonist for α4β2 nicotinic acetylcholine receptor (nAChR) with an EC50 value of 2.3 μM. Varenicline is a full agonist for α3β4 and α7 nAChRs with EC50 values of 55 μM and 18 μM, respectively[1]. Varenicline is a nicotinic ligand based on the structure of cytisine, has the potential for smoking cessation treatment[2].
References
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Mihalak KB, et al. Varenicline is a partial agonist at alpha4beta2 and a full agonist at alpha7 neuronal nicotinic receptors.Mol Pharmacol.?2006 Sep;70(3):801-5. Epub 2006 Jun 9. DOI:10.1124/mol.106.025130
[3] Bagdas D, et al. New insights on the effects of?varenicline?on nicotine reward, withdrawal and hyperalgesia in mice.Neuropharmacology.?2018 Aug;138:72-79. DOI:10.1016/j.neuropharm.2018.05.025
Varenicline-d4 Preparation Products And Raw materials
Raw materials
Preparation Products
Varenicline-d4 Suppliers
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9803
- Advantage
- 58
- Tel
- +86-400-002-6226 +86-13028896684;
- sales@rrkchem.com
- Country
- China
- ProdList
- 57422
- Advantage
- 58
- Tel
- 0551-66336380 18956014586
- Fax
- 055166336380
- 983438788@qq.com
- Country
- China
- ProdList
- 2297
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- sales@chemegen.com
- Country
- China
- ProdList
- 11218
- Advantage
- 58
- Tel
- +86-0755-66853366 +86-13670046396
- export03@qcsrm.com
- Country
- China
- ProdList
- 24342
- Advantage
- 58
- Tel
- 021-51600108 13062666369
- sales@isotopechem.com
- Country
- China
- ProdList
- 5000
- Advantage
- 58
- Tel
- 17301488900
- Fax
- 025-85560043
- judy.xia@synzest.com
- Country
- China
- ProdList
- 12582
- Advantage
- 58
- Tel
- 800-364-9897
- sales@caymanchem.com
- Country
- China
- ProdList
- 6838
- Advantage
- 58
- Tel
- 021-58056897 15399714481
- info@zsklab.com
- Country
- China
- ProdList
- 7190
- Advantage
- 58
- Tel
- 13631342304
- Country
- CHINA
- ProdList
- 188
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@neobioscience.com
- Country
- CHINA
- ProdList
- 6207
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@zzsrm.com
- Country
- CHINA
- ProdList
- 6650
- Advantage
- 58