Mn(III) Meso-Tetra (4-carboxyphenyl) porphine chloride
- Product Name
- Mn(III) Meso-Tetra (4-carboxyphenyl) porphine chloride
- CAS No.
- 55266-18-7
- Chemical Name
- Mn(III) Meso-Tetra (4-carboxyphenyl) porphine chloride
- Synonyms
- Mn(III)TBAP (chloride);MnTBAP chloride, 10 mM in DMSO;MnTBAP chloride, Superoxide dismutase (SOD) mimetic;Mn(III) Meso-Tetra (4-carboxyphenyl) porphine chloride;Manganese(III) meso-tetra(4-carboxyphenyl)porphine chloride;5,10,15,20-Tetrakis(4-carboxyphenyl)porphyrin-Mn(III) chloride (MnTBAP);5,10,15,20-Tetrakis(4-carboxyphenyl)-21H,23H-porphine]manganese(III) chloride
- CBNumber
- CB02709192
- Molecular Formula
- C48H28ClMnN4O8
- Formula Weight
- 879.148969
- MOL File
- 55266-18-7.mol
Mn(III) Meso-Tetra (4-carboxyphenyl) porphine chloride Property
- storage temp.
- -20C
- solubility
- Soluble in 0.1M NaOH
- form
- Brown solid
- color
- Black
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in 0.1M NaOH may be stored at -20° for up to 1 month.
- InChIKey
- XHVDAQLNUQLQKW-PTJHDCLZSA-K
- SMILES
- [Mn]1([n]2c3c(c5nc(c(c7[n]1c(c(c9nc(c(c2cc3)c%10ccc(cc%10)C(=O)O)cc9)c8ccc(cc8)C(=O)O)cc7)c6ccc(cc6)C(=O)O)cc5)c4ccc(cc4)C(=O)O)Cl
Safety
- WGK Germany
- WGK 1
- Storage Class
- 11 - Combustible Solids
N-Bromosuccinimide Price
- Product number
- 475870
- Product name
- MnTBAP - Calbiochem<br />MnTBAP, CAS 55266-18-7, is a cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger., Cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger.
- Packaging
- 25mg
- Price
- $114
- Updated
- 2025/07/31
- Product number
- 75850
- Product name
- Mn(III)TBAP (chloride)
- Packaging
- 25mg
- Price
- $41
- Updated
- 2024/03/01
- Product number
- 75850
- Product name
- Mn(III)TBAP (chloride)
- Packaging
- 50mg
- Price
- $78
- Updated
- 2024/03/01
- Product number
- 75850
- Product name
- Mn(III)TBAP (chloride)
- Packaging
- 10mg
- Price
- $19
- Updated
- 2024/03/01
- Product number
- 75850
- Product name
- Mn(III)TBAP (chloride)
- Packaging
- 100mg
- Price
- $138
- Updated
- 2024/03/01
Mn(III) Meso-Tetra (4-carboxyphenyl) porphine chloride Chemical Properties,Usage,Production
Description
MnTBAP (55266-18-7) is a superoxide dismutase (SOD) mimetic. Potent peroxynitrite scavenger but does not scavenge nitric oxide.
Uses
MnTBAP chloride is a cell permeable superoxide dismutase mimetic and peroxynitrite scavenger.
General Description
Cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. Protects endothelial cells in a dose-dependent manner (EC50 ~40 μM) against paraquat (2 mM). Inhibits the oxidation of Dihydrorhodamine 123 (Cat. No. 309825) by peroxynitrite, but does not scavenge nitric oxide (NO).
Biochem/physiol Actions
Cell permeable: yes
in vivo
MnTBAP chloride (10 mg/kg; IP; three times per week for twelve weeks) attenuates renal fibrosis in 5/6 Nx mice[1].
| Animal Model: | C57BL/6J mice with 5/6 nephrectomy (Nx)[1] |
| Dosage: | 10?mg/kg |
| Administration: | IP; three times per week for twelve weeks |
| Result: | Attenuated renal fibrosis in 5/6 Nx mice and reduced protein expressions of fibronectin, collagen III in remnant kidneys. |
IC 50
NFκB
References
[1] CSABA SZABÓ Andrew L S Brian J Day. Evaluation of the relative contribution of nitric oxide and peroxynitrite to the suppression of mitochondrial respiration in immunostimulated macrophages using a manganese mesoporphyrin superoxide dismutase mimetic and peroxynitrite scavenger[J]. FEBS Letters, 1996, 381 1-2: 82-86. DOI:10.1016/0014-5793(96)00087-7
[2] K M FAULKNER I F S I Liochev. Stable Mn(III) porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo.[J]. The Journal of Biological Chemistry, 1994, 269 38: 23471-23476.
Mn(III) Meso-Tetra (4-carboxyphenyl) porphine chloride Preparation Products And Raw materials
Raw materials
Preparation Products
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