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NOC-18

Product Name
NOC-18
CAS No.
146724-94-9
Chemical Name
NOC-18
Synonyms
NOC-18;NOC 18;DETA/NO;DETA NONOATE;DETA NONOate,97%;DETA-NONOate,NOC-18;NOC 18, DETA NONOate,;DIETHYLENETRIAMINE NONOATE;NOC-18 - CAS 146724-94-9 - Calbiochem;2,2'-(HYDROXYNITROSOHYDRAZINO)BIS-ETHAMINE
CBNumber
CB1665312
Molecular Formula
C4H13N5O2
Formula Weight
163.18
MOL File
146724-94-9.mol
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NOC-18 Property

Melting point:
98-106 °C
Boiling point:
290.26°C (rough estimate)
Density 
1.3102 (rough estimate)
refractive index 
1.8000 (estimate)
storage temp. 
-20°C
solubility 
H2O: >20 mg/mL
form 
solid
pka
4.50±0.69(Predicted)
color 
off-white
Stability:
Stable for 1 year from date of purchase as supplied. Store under inert gas. Solutions must be made fresh immediately before use and cannot be stored.
CAS DataBase Reference
146724-94-9
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
KH2502500
HS Code 
29270000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H242Heating may cause a fire

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P234Keep only in original container.

P235Keep cool.

P240Ground/bond container and receiving equipment.

P370+P378In case of fire: Use … for extinction.

P403Store in a well-ventilated place.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A5581
Product name
3,3-Bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene
Purity
≥95%
Packaging
10mg
Price
$262
Updated
2022/05/15
Sigma-Aldrich
Product number
487957
Product name
NOC-18
Packaging
10mg
Price
$205
Updated
2022/05/15
Cayman Chemical
Product number
82120
Product name
DETA NONOate
Purity
≥98%
Packaging
10mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
82120
Product name
DETA NONOate
Purity
≥98%
Packaging
50mg
Price
$116
Updated
2024/03/01
Sigma-Aldrich
Product number
D185
Product name
Diethylenetriamine/nitric oxide adduct
Purity
≥97% (NMR), solid
Packaging
10mg
Price
$47.5
Updated
2022/05/15
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NOC-18 Chemical Properties,Usage,Production

Description

DETA NONOate (146724-94-9) is a nitric oxide donor and dissociates to the free amine and NO in a pH dependent manner. The half-life of DETA NONOate in 0.1 M phosphate buffer at pH 7.4 is 20 hours at 37°C, or 56 hours at room temperature.1?Dissociation is essentially instantaneous at a pH of 5.0.

Chemical Properties

White Powder

Uses

A stable NO-amine complex which can release NO spontaneously under physiological conditions. The half life of NO release in 0.1 M PBS at (pH7.4) at 37?C for 0.1mM NOC 5 is 21 hours. Other applications include the induction of dose dependent apoptosis in macrophages, and inhibition of lipoprotein oxidation induced by Cu2+ in vitro.

Uses

3,3-Bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene has been used as a nitric oxide donor supplement for neuronal culture. It has also been used as a nitric oxide donor to study the effects of protein S-nitrosation (SNO) after nitrite treatment.

Definition

ChEBI: A nitroso compound that is triazane in which the the nitrogen at position 1 is substituted by two 2-aminoethyl groups, that at position 2 is substituted by a hydroxy group, and that at position 3 is substituted by an oxo group.

Biochem/physiol Actions

3,3-Bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene is a long-acting nitric oxide donor. It might exhibit nociceptive effects in rats.

References

1) Keefer?et al. (1996),?‘NONOates’ (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: Convenient nitric oxide dosage forms; Methods Enzymol.,?268?281

NOC-18 Preparation Products And Raw materials

Raw materials

Preparation Products

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NOC-18 Suppliers

Belgium 1 Canada 1 China 34 Europe 2 Germany 1 Japan 2 Switzerland 3 United Kingdom 6 United States 16 Global 66
J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
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86-10-82849933
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jkinfo@jkchemical.com
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Meryer (Shanghai) Chemical Technology Co., Ltd.
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021-61259108 18621169097
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86-21-61259102
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market03@meryer.com
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3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801 18930552037
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86-21-50328109
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3bsc@sina.com
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China
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Thermo Fisher Scientific
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800-810-5118
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+86-10-84193589
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cnchemical@thermofisher.com
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China
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Shanghai Macklin Biochemical Co.,Ltd.
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15221275939 15221275939
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021-50706099
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shenlinxing@macklin.cn
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China
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Sigma-Aldrich
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021-61415566 800-8193336
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orderCN@merckgroup.com
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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021-65675885
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info@efebio.com
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Guangdong wengjiang Chemical Reagent Co., Ltd.
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0751-2886750 13927877953
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0751-2886750
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3005811397@qq.com
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China
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Shandong Ono Chemical Co., Ltd.
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0539-6362799 20）
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0539-6362799（To 20）
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China
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Beijing OKA biological technology co., LTD
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010-010-62971590 18548936886
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010-62340519
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3462612863@qq.com
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146724-94-9, NOC-18Related Search:

DEA NONOate GEA 5024 Sodium nitroprusside dihydrate DPTA NONOATE SPERMINE NONOATE NOC-7 MAHMA NONOATE 4-(N-CYANOMETHYL-N-NITROSO)AMINOMORPHOLINE S-NITROSOGLUTATHIONE NOC-5 BETA-GAL-NONOATE NOR-3 PAPA NONOATE GEA 3162 V-PYRRO/NO NOC-18 1-HYDROXY-2-OXO-3,3-BIS(2-AMINO ETHYL)-1-TRIAZENE (NOC-18) NOC 18

  • DETA NONOate,97%
  • NOC-18;DIETHYLENETRIAMINE NONOATE;3,3-BIS(AMINOETHYL)-1-HYDROXY-2-OXO-1-TRIAZENE
  • DIETHYLENETRIAMINE NONOATE
  • DETA/NO
  • DETA NONOATE
  • NOC-18
  • (Z)-1-[N-(2-AMINOETHYL)-N-(2-AMMONIOETHYL)AMINO]DIAZEN-1-IUM-1,2-DIOLATE
  • (Z)-1-[2-(2-AMINOETHYL)-N-(2-AMMONIOETHYL)AMINO]DIAZEN-1-IUM-1,2-DIOLATE
  • 3,3-BIS(AMINOETHYL)-1-HYDROXY-2-OXO-1-TRIAZENE
  • 2,2'-(HYDROXYNITROSOHYDRAZINO)BIS-ETHAMINE
  • 2,2'-(HYDROXYNITROSOHYDRAZINO)BIS-ETHANAMINE
  • 1-HYDROXY-2-OXO-3,3-BIS(3-AMINOETHYL)-1-TRIAZENE
  • NOC 18
  • DETA-NONOate,NOC-18
  • NOC 18, DETA NONOate,
  • 2,2μ-(Hydroxynitrosohydrazono)bis-ethanimine, DETA/NO
  • 2,2μ-(Hydroxynitrosohydrazino)bis-ethanamine, DETA NONOate, NOC-18
  • 1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane
  • 2-[2-aminoethyl-[nitroso(oxido)amino]amino]ethylazanium
  • 2,2'-(2-Hydroxy-2-nitrosohydrazinylidene)bis-ethanamine
  • NOC-18 - CAS 146724-94-9 - Calbiochem
  • Ethanamine, 2,2'-(2-hydroxy-2-nitrosohydrazinylidene)bis-
  • 146724-94-9
  • Biochemicals and Reagents
  • Application Index
  • BioChemical
  • Cell Signaling Enzymes
  • NO Donors
  • Nitric Oxide Metabolism
  • Enzymes, Inhibitors, and Substrates
  • Nitric Oxide Reagents