NOC-18 Property

Melting point:

98-106 °C

Boiling point:

290.26°C (rough estimate)

Density 

1.3102 (rough estimate)

refractive index 

1.8000 (estimate)

storage temp. 

-20°C

solubility 

H₂O: >20 mg/mL

form 

solid

pka

4.50±0.69(Predicted)

color 

off-white

Stability:

Stable for 1 year from date of purchase as supplied. Store under inert gas. Solutions must be made fresh immediately before use and cannot be stored.

CAS DataBase Reference

146724-94-9

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

RTECS 

KH2502500

HS Code 

29270000

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H242Heating may cause a fire

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P234Keep only in original container.

P235Keep cool.

P240Ground/bond container and receiving equipment.

P370+P378In case of fire: Use … for extinction.

P403Store in a well-ventilated place.

NOC-18 Chemical Properties,Usage,Production

Description

DETA NONOate (146724-94-9) is a nitric oxide donor and dissociates to the free amine and NO in a pH dependent manner. The half-life of DETA NONOate in 0.1 M phosphate buffer at pH 7.4 is 20 hours at 37°C, or 56 hours at room temperature.1?Dissociation is essentially instantaneous at a pH of 5.0.

Chemical Properties

White Powder

Uses

A stable NO-amine complex which can release NO spontaneously under physiological conditions. The half life of NO release in 0.1 M PBS at (pH7.4) at 37?C for 0.1mM NOC 5 is 21 hours. Other applications include the induction of dose dependent apoptosis in macrophages, and inhibition of lipoprotein oxidation induced by Cu2+ in vitro.

Uses

3,3-Bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene has been used as a nitric oxide donor supplement for neuronal culture. It has also been used as a nitric oxide donor to study the effects of protein S-nitrosation (SNO) after nitrite treatment.

Definition

ChEBI: A nitroso compound that is triazane in which the the nitrogen at position 1 is substituted by two 2-aminoethyl groups, that at position 2 is substituted by a hydroxy group, and that at position 3 is substituted by an oxo group.

Biochem/physiol Actions

3,3-Bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene is a long-acting nitric oxide donor. It might exhibit nociceptive effects in rats.

References

1) Keefer?et al. (1996),?‘NONOates’ (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: Convenient nitric oxide dosage forms; Methods Enzymol.,?268?281