ChemicalBook > CAS DataBase List > NOC-18
NOC-18
- Product Name
- NOC-18
- CAS No.
- 146724-94-9
- Chemical Name
- NOC-18
- Synonyms
- NOC-18;NOC 18;DETA/NO;DETA NONOATE;DETA NONOate,97%;DETA-NONOate,NOC-18;NOC 18, DETA NONOate,;DIETHYLENETRIAMINE NONOATE;DETA NONOate（Diethylamine NONOate;NOC-18 - CAS 146724-94-9 - Calbiochem
- CBNumber
- CB1665312
- Molecular Formula
- C4H13N5O2
- Formula Weight
- 163.18
- MOL File
- 146724-94-9.mol
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NOC-18 Property
- Melting point:
- 98-106 °C
- Boiling point:
- 290.26°C (rough estimate)
- Density
- 1.3102 (rough estimate)
- refractive index
- 1.8000 (estimate)
- storage temp.
- -20°C
- solubility
- H2O: >20 mg/mL
- form
- solid
- pka
- 4.50±0.69(Predicted)
- color
- off-white
- Stability:
- Stable for 1 year from date of purchase as supplied. Store under inert gas. Solutions must be made fresh immediately before use and cannot be stored.
- CAS DataBase Reference
- 146724-94-9
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H242Heating may cause a fire
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P234Keep only in original container.
P235Keep cool.
P240Ground/bond container and receiving equipment.
P370+P378In case of fire: Use … for extinction.
P403Store in a well-ventilated place.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- A5581
- Product name
- 3,3-Bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $262
- Updated
- 2022/05/15
Sigma-Aldrich
- Product number
- 487957
- Product name
- NOC-18
- Packaging
- 10mg
- Price
- $205
- Updated
- 2022/05/15
Cayman Chemical
- Product number
- 82120
- Product name
- DETA NONOate
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $37
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 82120
- Product name
- DETA NONOate
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $116
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- D185
- Product name
- Diethylenetriamine/nitric oxide adduct
- Purity
- ≥97% (NMR), solid
- Packaging
- 10mg
- Price
- $47.5
- Updated
- 2022/05/15
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NOC-18 Chemical Properties,Usage,Production
Description
DETA NONOate (146724-94-9) is a nitric oxide donor and dissociates to the free amine and NO in a pH dependent manner. The half-life of DETA NONOate in 0.1 M phosphate buffer at pH 7.4 is 20 hours at 37°C, or 56 hours at room temperature.1?Dissociation is essentially instantaneous at a pH of 5.0.
Chemical Properties
White Powder
Uses
A stable NO-amine complex which can release NO spontaneously under physiological conditions. The half life of NO release in 0.1 M PBS at (pH7.4) at 37?C for 0.1mM NOC 5 is 21 hours. Other applications include the induction of dose dependent apoptosis in macrophages, and inhibition of lipoprotein oxidation induced by Cu2+ in vitro.
Uses
3,3-Bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene has been used as a nitric oxide donor supplement for neuronal culture. It has also been used as a nitric oxide donor to study the effects of protein S-nitrosation (SNO) after nitrite treatment.
Definition
ChEBI: A nitroso compound that is triazane in which the the nitrogen at position 1 is substituted by two 2-aminoethyl groups, that at position 2 is substituted by a hydroxy group, and that at position 3 is substituted by an oxo group.
Biochem/physiol Actions
3,3-Bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene is a long-acting nitric oxide donor. It might exhibit nociceptive effects in rats.
References
1) Keefer?et al. (1996),?‘NONOates’ (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: Convenient nitric oxide dosage forms; Methods Enzymol.,?268?281
NOC-18 Preparation Products And Raw materials
Raw materials
Preparation Products
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NOC-18
1-HYDROXY-2-OXO-3,3-BIS(2-AMINO ETHYL)-1-TRIAZENE (NOC-18)
NOC 18