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Savolitinib

Product Name
Savolitinib
CAS No.
1313725-88-0
Chemical Name
Savolitinib
Synonyms
Savolitinib;HMPL-504;Savolitinib (AZD6094);CS-2676;Volitinib;AZD-6094);EOS-60799;HMPL0-504;Volitinib USP/EP/BP;AZD-6094 (VOLITINIB)
CBNumber
CB02731160
Molecular Formula
C17H15N9
Formula Weight
345.36
MOL File
1313725-88-0.mol
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Savolitinib Property

Melting point:
205-207°C
Density 
1.55±0.1 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
5.67±0.50(Predicted)
form 
Solid
color 
Pale Beige
InChI
InChI=1S/C17H15N9/c1-11(12-3-4-15-18-5-6-25(15)10-12)26-17-16(22-23-26)19-8-14(21-17)13-7-20-24(2)9-13/h3-11H,1-2H3/t11-/m0/s1
InChIKey
XYDNMOZJKOGZLS-NSHDSACASA-N
SMILES
C12N=NN([C@H](C3=CN4C=CN=C4C=C3)C)C1=NC(C1=CN(C)N=C1)=CN=2
CAS DataBase Reference
1313725-88-0
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
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N-Bromosuccinimide Price

TRC
Product number
S142903
Product name
Savolitinib
Packaging
100mg
Price
$1215
Updated
2021/12/16
ChemScene
Product number
CS-4062
Product name
Savolitinib
Purity
99.56%
Packaging
100mg
Price
$850
Updated
2021/12/16
ChemScene
Product number
CS-4062
Product name
Savolitinib
Purity
99.56%
Packaging
5mg
Price
$100
Updated
2021/12/16
Biosynth Carbosynth
Product number
BV160378
Product name
Volitinib
Packaging
5mg
Price
$100
Updated
2021/12/16
Biosynth Carbosynth
Product number
BV160378
Product name
Volitinib
Packaging
50mg
Price
$600
Updated
2021/12/16
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Savolitinib Chemical Properties,Usage,Production

Description

Savolitinib selectively inhibits the MET receptor, blocking the PI3K/AKT/MAPK-signaling pathway as well as downregulating MYC.

Uses

Savolitinib is a potent and highly selective c-Met inhibitor. Savoltinib demonstrated anti-tumor efficacy in a panel of cMet-dysregulated gastric cancer PDX models. Savolitinib also demonstrated good antitmuor activities.

Clinical Use

It is currently being evaluated in phase I clinical trials in combination with EGFR TKIs in NSCLC patients.

Synthesis

The synthesis of savolitinib started with 6-amino-3-carboxypyridine (20.1), which was treated with chloroacetaldehyde to generate the imidazopyridine 20.2. The carboxylic acid was converted to the Weinreb amide 20.3 and treated with methylmagnesium bromide to give the methyl ketone 20.4. The ketone was converted to the chiral amine 20.5 using a commercially available aminotransferase with the cofactors pyridoxal phosphate and isopropylamine as a nitrogen source. After process workup, the amine was isolated as the dihydrochloride salt (20.5). The free base was obtained by treatment with alkaline conditions, which was subsequently reacted with commercially available 3,5-dibromopyrazin-2-amine (20.6) to give the secondary amine 20.7. Next, nitrosyl ion formation and cyclization gave the 1,2,3-triazole 20.8. Finally, Suzuki coupling with 20.9 completed the construction of savolitinib (20). The boronic acid ester 20.9 was obtained from 4-bromo-1-methyl-1H-pyrazole by lithium-halogen exchange and workup with triisopropylborate quenching.

in vivo

Savolitinib (Compound 28; 1-10.0 mg/kg; oral administration; daily; for 21 days; athymic nude mice) demonstrates dose-dependent tumor growth inhibition in a U87MG subcutaneous xenograft model. In addition, none of the mice in the dosing groups exhibits body weight loss during the experiment[1].

Animal Model:U87MG xenograft model in athymic nude mice[1]
Dosage:1 mg/kg, 2.5 mg/kg and 10.0 mg/kg
Administration:Oral administration; daily; for 21 days
Result:Demonstrated dose-dependent tumor growth inhibition in a U87MG subcutaneous xenograft model.

Savolitinib Preparation Products And Raw materials

Raw materials

Preparation Products

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Savolitinib Suppliers

China 140 India 1 United States 8 Global 149
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19552
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
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View Lastest Price from Savolitinib manufacturers

Sinoway Industrial co., ltd.
Product
Volitinib 1313725-88-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20tons
Release date
2025-04-07
Hong Kong Tiansheng New Material Trading Co., Ltd
Product
Savolitinib 1313725-88-0
Price
US $38.99/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2021-12-27
Dideu Industries Group Limited
Product
Volitinib 1313725-88-0
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-07-05

1313725-88-0, SavolitinibRelated Search:

Selumetinib Sulfate Ibrutinib SU 6668 3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione INCB39110 X-376 Filgotinib Masitinib Lestaurtinib CAL-101 PLX3397 (Pexidartinib) CO-1686 Momelotinib Verteporfin PLX4032 1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-2-propanol ARRY-334543 Decernotinib

  • AZD6094,Volitinib, HMPL-504, Savolitinib
  • 1-[(1S)-1-Imidazo[1,2-a]pyridin-6-ylethyl]-6-(1-methyl-1H-pyrazol-4-yl)-1H-1,2,3-triazolo[4,5-b]pyrazine
  • (S)-1-(1-(imidazo[1,2-a]pyridin-6-yl)ethyl)-6-(1-methyl-1H-pyrazol-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine
  • Volitinib
  • Savolitinib
  • HMPL-504(AZD6094, Volitinib)
  • EOS-60799
  • AZD-6094)
  • HMPL-504
  • Savolitinib (Volitinib
  • (S)-1-(1-(imidazo[1,2-a] yridine-6-yl)ethyl)-6-(1-methyl-1H-pyrazol-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine
  • Savolitinib (AZD6094)
  • (S)-1-(1-(IMIDAZO[1,2-A]
  • HMPL-504; HMPL504; HMPL504; AZD-6094; AZD 6094; AZD6094
  • Volitinib (Savolitinib, AZD-6094)
  • CS-2676
  • VOLITINIB; HMPL504; AZD-6094;VOLITINIB; HMPL-504; AZD6094; HMPL 504; AZD 6094
  • Savolitinib(AZD6094, HMPL-504)
  • 1H-1,2,3-Triazolo[4,5-b]pyrazine, 1-[(1S)-1-imidazo[1,2-a]pyridin-6-ylethyl]-6-(1-methyl-1H-pyrazol-4-yl)-
  • Volitinib USP/EP/BP
  • 4-{1-[(1S)-1-{imidazo[1,2-a]pyridin-6-yl}ethyl]-1H-[ 1,2,3]triazolo[4,5-b]pyrazin-6-yl}-1-methyl-1H-pyra zole
  • Pharmaceutical Intermediate Volitinib
  • AZD-6094 (VOLITINIB)
  • VOLITINIB (AZD6094, SAVOLITINIB)
  • HMPL0-504
  • Savolitinib, 10 mM in DMSO
  • 1313725-88-0
  • API