VBY-825

Product Name: VBY-825
CAS No.: 1310340-58-9
Chemical Name: VBY-825
Synonyms: VBY-825;VBY-825,VBY 825,Cathepsin,Inhibitor,VBY825,inhibit;Pentanamide, N-cyclopropyl-3-[[(2R)-3-[(cyclopropylmethyl)sulfonyl]-1-oxo-2-[[(1S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethyl]amino]propyl]amino]-2-oxo-, (3S)-
CBNumber: CB02736695
Molecular Formula: C23H29F4N3O5S
Formula Weight: 535.55
MOL File: 1310340-58-9.mol

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VBY-825 Property

Density: 1.39±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 125 mg/mL (233.40 mM);Water : < 0.1 mg/mL (insoluble)
form: Solid
pka: 11.83±0.20(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: V099605
Product name: VBY-825
Packaging: 0.5mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-3901
Product name: VBY-825
Purity: 99.84%
Packaging: 5mg
Price: $850
Updated: 2021/12/16

ChemScene

Product number: CS-3901
Product name: VBY-825
Purity: 99.84%
Packaging: 10mg
Price: $1450
Updated: 2021/12/16

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VBY-825 Chemical Properties,Usage,Production

Uses

VBY-825 is a novel, reversible cathepsin inhibitor which has high potency against cathepsins B, L, S and V. VBY-825 is also a new and effective anti-tumor drug.

in vivo

VBY-825 (10 mg/kg, via gavage, once daily, 14 days) reduces pain behaviors in a mouse bone cancer model^[2].
VBY-825 inhibits inflammation in mouse models of gout, peritonitis, and arthritis^[3].

Animal Model:	Mouse bone cancer model^[2]
Dosage:	10 mg/kg; daily; 14 days
Administration:	i.g.
Result:	Reduced withdrawal and guarding of spontaneous bone cancer-induced pain.

IC 50

cathepsin K; cathepsin S

VBY-825 Preparation Products And Raw materials

Raw materials

Preparation Products

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VBY-825 Suppliers

China 27 United States 4 Global 31

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VBY-825

Pentanamide, N-cyclopropyl-3-[[(2R)-3-[(cyclopropylmethyl)sulfonyl]-1-oxo-2-[[(1S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethyl]amino]propyl]amino]-2-oxo-, (3S)-

VBY-825,VBY 825,Cathepsin,Inhibitor,VBY825,inhibit

1310340-58-9

C23H29F4N3O5S