1-Fluoro-3-iodobenzene
- Product Name
- 1-Fluoro-3-iodobenzene
- CAS No.
- 1121-86-4
- Chemical Name
- 1-Fluoro-3-iodobenzene
- Synonyms
- 3-FLUOROIODOBENZENE;m-Fluorobenzene;M-FLUOROIODOBENZENE;3-Iodofluorobenzene;m-Iodofluorobenzene;3- Fluoriodobenzene;1-fluoro-3-iodo-benzen;3-Fluoro-1-iodobenzene;1-Iodo-3-fluorobenzene;1-FLUORO-3-IODOBENZENE
- CBNumber
- CB0284196
- Molecular Formula
- C6H4FI
- Formula Weight
- 222
- MOL File
- 1121-86-4.mol
1-Fluoro-3-iodobenzene Property
- Melting point:
- -42°C
- Boiling point:
- 77-78 °C/19 mmHg (lit.)
- Density
- 1.89 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.584(lit.)
- Flash point:
- 153 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- Liquid
- Specific Gravity
- 1.890
- color
- Clear yellow or pink
- Sensitive
- Light Sensitive
- BRN
- 2039305
- InChI
- 1S/C6H4FI/c7-5-2-1-3-6(8)4-5/h1-4H
- InChIKey
- VSKSBSORLCDRHS-UHFFFAOYSA-N
- SMILES
- Fc1cccc(I)c1
- CAS DataBase Reference
- 1121-86-4(CAS DataBase Reference)
- NIST Chemistry Reference
- Benzene, 1-fluoro-3-iodo-(1121-86-4)
- EPA Substance Registry System
- m-Fluoroiodobenzene (1121-86-4)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-37/39
- WGK Germany
- 3
- TSCA
- TSCA listed
- HazardClass
- IRRITANT
- HS Code
- 29039990
- Storage Class
- 10 - Combustible liquids
- Hazard Classifications
- Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 219398
- Product name
- 3-Fluoroiodobenzene
- Purity
- 99%
- Packaging
- 25g
- Price
- $73.22
- Updated
- 2025/07/31
- Product number
- F0260
- Product name
- 1-Fluoro-3-iodobenzene (stabilized with Copper chip)
- Purity
- >99.0%(GC)
- Packaging
- 25g
- Price
- $103
- Updated
- 2025/07/31
- Product number
- B434808
- Product name
- 1-fluoro-3-iodobenzene
- Packaging
- 2.5g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 409780
- Product name
- 1-fluoro-3-iodobenzene
- Packaging
- 500mg
- Price
- $305
- Updated
- 2021/12/16
- Product number
- 278213
- Product name
- 1-Fluoro-3-iodobenzene
- Packaging
- 25g
- Price
- $350
- Updated
- 2021/12/16
1-Fluoro-3-iodobenzene Chemical Properties,Usage,Production
Chemical Properties
clear yellow or pink liquid
Uses
3-Fluoroiodobenzene was used to prepare methyl 4-iodobenzo[b]thiophene-2-carboxylate, key intermediate for the synthesis of 4-substituted benzo[b]thiophene-2-carboxamidines.
General Description
3-Fluoroiodobenzene participates in palladium-catalyzed hydroarylation of arylpropiolamides.
Synthesis
372-19-0
1121-86-4
The general procedure for the synthesis of m-fluoroiodobenzene from 3-fluoroaniline was as follows: an aqueous solution (20 mL) of NaNO2 (6.4 g, 92.75 mmol) was slowly added dropwise at 0 °C to a solution of 3-fluoroaniline (10 g, 90.09 mmol) dissolved in 32% H2SO4 (179 g). The reaction mixture was stirred continuously at 0 °C for 1 hour. Subsequently, an aqueous solution (30 mL) of KI (22.4 g, 134.94 mmol) was added while maintaining 0 °C and stirring was continued at 0 °C for 1 hour. After completion of the reaction, the aqueous phase was extracted with EtOAc (2 x 250 mL). The organic phases were combined and washed sequentially with water (5×200mL) and 10% NaHSO3 solution (3×200mL), dried over Na2SO4 and concentrated under reduced pressure to remove the solvent, yielding 17.7 g of 1-fluoro-3-iodobenzene as a yellow solid in 82% yield.
References
[1] Patent: WO2008/103615, 2008, A1. Location in patent: Page/Page column 40
[2] Journal of the American Chemical Society, 1963, vol. 85, p. 709 - 724
1-Fluoro-3-iodobenzene Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-Fluoro-3-iodobenzene manufacturers
- Product
- 1-Fluoro-3-iodobenzene 1121-86-4
- Price
- US $4.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10000
- Release date
- 2024-09-06
- Product
- 1-Fluoro-3-iodobenzene 1121-86-4
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-12-02
- Product
- 3-iodofluorobenzene 1121-86-4
- Price
- US $250.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 20 tons
- Release date
- 2019-12-24