2-FLUORO-6-IODOBENZOIC ACID
- Product Name
- 2-FLUORO-6-IODOBENZOIC ACID
- CAS No.
- 111771-08-5
- Chemical Name
- 2-FLUORO-6-IODOBENZOIC ACID
- Synonyms
- CAS:111771-08-5;TIMTEC-BB SBB006699;RARECHEM AL BO 0280;2-Fluoro-6-iodobenzoic;2-FLUORO-6-IODOBENZOATE;2-FLUORO-6-IODOBENZOIC ACID;2-Fluoro-6-iodobenzoicAcid>2-Fluoro-6-iodobenzoicacid98%;Benzoic acid, 2-fluoro-6-iodo-;2-Fluoro-6-iodobenzoic acid 98%
- CBNumber
- CB9716814
- Molecular Formula
- C7H4FIO2
- Formula Weight
- 266.01
- MOL File
- 111771-08-5.mol
2-FLUORO-6-IODOBENZOIC ACID Property
- Melting point:
- 123-126 °C (lit.)
- Boiling point:
- 301.6±27.0 °C(Predicted)
- Density
- 1.9575 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- pka
- 1.93±0.10(Predicted)
- form
- Powder
- color
- Yellow to light brown
- Sensitive
- Light Sensitive
- BRN
- 4982371
- InChI
- 1S/C7H4FIO2/c8-4-2-1-3-5(9)6(4)7(10)11/h1-3H,(H,10,11)
- InChIKey
- CYCXAPWOBWWNRK-UHFFFAOYSA-N
- SMILES
- OC(=O)c1c(F)cccc1I
- CAS DataBase Reference
- 111771-08-5(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 429910
- Product name
- 2-Fluoro-6-iodobenzoic acid
- Purity
- 97%
- Packaging
- 5g
- Price
- $214
- Updated
- 2025/07/31
- Product number
- F0796
- Product name
- 2-Fluoro-6-iodobenzoic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $26
- Updated
- 2025/07/31
- Product number
- F0796
- Product name
- 2-Fluoro-6-iodobenzoic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $73
- Updated
- 2025/07/31
- Product number
- F591983
- Product name
- 2-Fluoro-6-iodobenzoic Acid
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- F591983
- Product name
- 2-Fluoro-6-iodobenzoic Acid
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
2-FLUORO-6-IODOBENZOIC ACID Chemical Properties,Usage,Production
Chemical Properties
yellow to light brown powder
Uses
2-Fluoro-6-iodobenzoic acid may be used for the synthesis of fluoro-substituted benzoyl chlorides. It may be used for the one-pot regioselective synthesis of isocoumarins.
General Description
2-Fluoro-6-iodobenzoic acid is loose white crystal. It can be synthesized by using 2-amino-6-fluorobenzoic acid as the starting material.
Synthesis
124-38-9
1121-86-4
111771-08-5
At -70°C, n-butyllithium (n-BuLi, 120 mL) was slowly added dropwise to an ether (300 mL) solution of diisopropylamine (33.33 g, 330.00 mmol). The resulting solution was stirred continuously at -70 °C for 1 h. Subsequently, a solution of 1-fluoro-3-iodobenzene (22.2 g, 100.00 mmol) in ether (100 mL) was added. After continued stirring at -70 °C for 1 h, carbon dioxide (CO2, gas) was passed into the reaction mixture. The reaction mixture was stirred at -50°C for 1 hour. After the reaction was completed, the reaction mixture was extracted with deionized water (1 x 300 mL). The pH of the aqueous layer was adjusted to 1 by dropwise addition of 4 M hydrochloric acid (HCl), followed by extraction of the aqueous layer with ethyl acetate (EtOAc, 3 × 300 mL). The organic layers were combined, washed with saturated saline (2 × 100 mL), dried over anhydrous sodium sulfate (Na2SO4), and concentrated to dryness under reduced pressure to afford 8 g (33% yield) of 2-fluoro-6-iodobenzoic acid as a yellow solid.
References
[1] European Journal of Organic Chemistry, 2002, # 19, p. 3351 - 3358
[2] Synthesis, 2005, # 4, p. 617 - 621
[3] Patent: WO2008/103615, 2008, A1. Location in patent: Page/Page column 41
2-FLUORO-6-IODOBENZOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-FLUORO-6-IODOBENZOIC ACID manufacturers
- Product
- 2-FLUORO-6-IODOBENZOIC ACID 111771-08-5
- Price
- US $8.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg
- Release date
- 2019-07-12