5-Fluoro-2-iodobenzoic acid
- Product Name
- 5-Fluoro-2-iodobenzoic acid
- CAS No.
- 52548-63-7
- Chemical Name
- 5-Fluoro-2-iodobenzoic acid
- Synonyms
- 5-Fluoro-2-iodobenzoic acid;5-Flluoro-2-iodobenzoic acid;Benzoic acid, 5-fluoro-2-iodo-
- CBNumber
- CB7947162
- Molecular Formula
- C7H4FIO2
- Formula Weight
- 266.01
- MOL File
- 52548-63-7.mol
5-Fluoro-2-iodobenzoic acid Property
- Melting point:
- 145-149 °C
- Boiling point:
- 307.9±27.0 °C(Predicted)
- Density
- 2.074±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 2.52±0.10(Predicted)
- color
- White to Light yellow to Light orange
- Sensitive
- Light Sensitive
- InChI
- InChI=1S/C7H4FIO2/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3H,(H,10,11)
- InChIKey
- XPFMQYOPTHMSJJ-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC(F)=CC=C1I
Safety
- Hazard Codes
- T
- Risk Statements
- 25-36/37/38
- Safety Statements
- 26-45
- RIDADR
- UN 2811
- WGK Germany
- 3
- HazardClass
- 6.1
- PackingGroup
- Ⅲ
- HS Code
- 2916310090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 678902
- Product name
- 5-Fluoro-2-iodobenzoic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $141
- Updated
- 2025/07/31
- Product number
- F1113
- Product name
- 5-Fluoro-2-iodobenzoic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $87
- Updated
- 2025/07/31
- Product number
- F1113
- Product name
- 5-Fluoro-2-iodobenzoic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $347
- Updated
- 2025/07/31
- Product number
- F592003
- Product name
- 5-Fluoro-2-iodobenzoic acid
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- F592003
- Product name
- 5-Fluoro-2-iodobenzoic acid
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
5-Fluoro-2-iodobenzoic acid Chemical Properties,Usage,Production
Uses
5-Fluoro-2-iodobenzoic acid is an important intermediate for the production of pharmaceuticals and agrochemicals.
Synthesis
446-08-2
52548-63-7
Step 1: 2-Amino-5-fluorobenzoic acid (25 g, 0.162 mol) was dissolved in 2N HCl solution (350 mL) and cooled to 0-5°C. At this temperature, a solution of sodium nitrite (11.2 g, 0.16 mol) in water (150 mL) was slowly added dropwise. After the dropwise addition was completed, the reaction mixture was continued to be stirred at 0-5°C for 90 min. Subsequently, the resulting diazonium salt solution was added dropwise to a solution of potassium iodide (53 g, 0.32 mol) and cuprous(I) iodide (15.2 g, 0.081 mol) in water (150 mL) that had been pre-cooled to about 5 °C. After completion of the dropwise addition, the reaction mixture was transferred to room temperature and stirred for 18 hours. The completion of the reaction was monitored by TLC (unfolding agent: EtOAc). At the end of the reaction, the mixture was filtered and the solid product was collected. The solid residue was diluted with methyl tert-butyl ether (MTBE, 500 mL), refluxed for 20 min and filtered. The filtrate was concentrated to give 5-fluoro-2-iodobenzoic acid (30 g, 75% yield) as a yellow solid. The product was characterized by 1H NMR (400 MHz, methanol-d4): δ 8.04-8.00 (m, 1H), 7.59-7.56 (m, 1H), 7.08-7.03 (m, 1H).
References
[1] Patent: WO2013/132376, 2013, A1. Location in patent: Page/Page column 151
[2] Chemistry--A European Journal, 2014, vol. 20, # 36, p. 11336 - 11339,4
[3] Patent: US2006/52378, 2006, A1. Location in patent: Page/Page column 146
[4] Patent: US2003/187014, 2003, A1
[5] Patent: WO2010/31, 2010, A1. Location in patent: Page/Page column 70
5-Fluoro-2-iodobenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Fluoro-2-iodobenzoic acid manufacturers
- Product
- 5-Fluoro-2-iodobenzoic acid 52548-63-7
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-08
- Product
- 5-Fluoro-2-iodobenzoic acid 52548-63-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-08
- Product
- 5-Fluoro-2-iodobenzoic acid 52548-63-7
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-09