Mancozeb Property

Melting point:

192-194°C

Density 

1.92 g/cm3

vapor pressure 

Negligible at 20 °C

Flash point:

138 °C

storage temp. 

APPROX 4°C

solubility 

DMSO: 1 mg/mL (1.51 mM); Water: < 0.1 mg/mL (insoluble)

Water Solubility 

6-20 mgl^-1 (20 °C)

form 

Solid:particulate/powder

Merck 

13,5738

LogP

1.8-2.3 at 20℃ and pH6-10

Dissociation constant

12.09 at 20℃

CAS DataBase Reference

8018-01-7(CAS DataBase Reference)

EPA Substance Registry System

Mancozeb (8018-01-7)

Safety

Hazard Codes 

Xi,N,Xn

Risk Statements 

37-43-50-63

Safety Statements 

8-24/25-46-61-36/37

RIDADR 

UN 2210

RTECS 

ZB3200000

HazardClass 

9

PackingGroup 

III

HS Code 

29309090

Hazardous Substances Data

8018-01-7(Hazardous Substances Data)

Toxicity

LC50 (48-hour) for carp 4.0 mg/L (Hartley and Kidd, 1987), catfish 5.2 mg/L, goldfish 9.0 mg/L (21°C) and rainbow trout 2.2 mg/L (17°C) (Worthing and Hance, 1991); acute oral LD50 for rats >8,000 mg/kg (Hartley and Kidd, 1987), mouse 600 mg/kg (RTECS, 1985).

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H317May cause an allergic skin reaction

H351Suspected of causing cancer

H373May cause damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P281Use personal protective equipment as required.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P308+P313IF exposed or concerned: Get medical advice/attention.

P314Get medical advice/attention if you feel unwell.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P391Collect spillage. Hazardous to the aquatic environment

P405Store locked up.

P501Dispose of contents/container to..…

Mancozeb Chemical Properties,Usage,Production

Description

Mancozeb is a fungicide of the ethylene-bis-dit-hiocarbamate group. It is present in Rondo-M with pyrifenox. Occupational exposure occurs mainly in agricultural workers, in vineyard workers or in florists.

Chemical Properties

Grayish-yellow powder

Uses

Fungicide used as a foliar or seed treatment to control a wide variety of pathogens in many field crops, fruits, ornamentals and vegetables.

Uses

Mancozeb is a mixture of Maneb (M163500) and Zineb, a manganese and zinc (1:1) complex mixture with the ethylene bis(dithiocarbamate) anionic ligand. Mancozeb is a foliate fungicide used to protect cr ops in agriculture. Mancozeb has a broader and more effective fungacidal activity than either of its component on their own. Mancozeb also significantly enhances the copper activity against several ba cteriosis.

Uses

Fungicide.

Uses

Mancozeb is a contact fungicide that provides protection against a wide variety of fungal diseases (including rots, leaf spot, blight, rust, downy mildew, scab, etc.) in field crops, fruits, vines, vegetables, ornamentals, potatoes, turf, berries, rice, citrus and cereals. Mancozeb is a mixture containing zineb and maneb as active ingredients.

Agricultural Uses

Fungicide: Mancozeb is used to control a wide variety of fungal diseases, including potato blight, leaf spot, scab (on apples and pears), and rust (on roses). It is used on fruits, vegetables, nuts and field crops, and many more. It is also used as a seed treatment of cotton, potatoes, corn, safflower, sorghum, peanuts, tomatoes, flax, and cereal grains.

Trade name

ACROBAT® (mancozeb + dimethomorph); ASHLAND SOLACE® (cymoxanil + mancozeb); CARMAZINE®; CUPROFIX®; DITHANE®; EMCARB® (mancozeb + carbendez); EMTHANE M-15®; EVOLVE®; F 2966®; FORE®; FORMEC®; GAUCHO® (imidacloprid + mancozeb); GAVEL® (mancozeb + zoxamide); GREEN-DAISEN M®; KARAMATE®; KENCOZEB®; MANCOFOL®; MANOSEB®; MANTOX®; MANZATE 200®; MANZEB®; MANZIN 80®; MARZIN®; MAXIM®; MILOR®; NEMISPOR®; PACE® fungicide (mixture of mancozeb and metalaxyl); PENNCOZEB®; POLICAR®; TRIZIMAN®; TRIZIMAN-D®; VONDOZEB PLUS®; ZIMANAT®; ZIMMAN-DITHANE®; ZIMANEB®

Contact allergens

Mancozeb is a fungicide of the ethylene-bis-dithiocarbamate group. It is present in Rondo-M? with pyrifenox.Occupational exposure occurs mainly in agriculturalworkers, in vineyard workers, or in florists.

Potential Exposure

Mancozeb is a dithiocarbamate fungicide. It is used to control a wide variety of fungal diseases, including potato blight, leaf spot, scab (on apples and pears), and rust (on roses). It is used on fruits, vegetables, nuts and field crops, and many more. It is also used as a seed treatment of cotton, potatoes, corn, safflower, sorghum, peanuts, tomatoes, flax, and cereal grains

Environmental Fate

Plant. Undergoes metabolism in plants to ethyl thiourea, ethylene thiuram disulfide, thiuram monosulfide and sulfur (Hartley and Kidd, 1987).
Chemical/Physical. Decomposes in acids releasing carbon disulfide. In oxygenated waters, mancozeb degraded to ethylene thiuram monosulfide, ethylene diisocyanate, ethylene thiourea, ethylenediamine and sulfur (Worthing and Hance, 1991).

Metabolic pathway

Mancozeb is a mixture containing maneb and zineb as the active ingredients. Maneb and zineb and other alkylenebis( dithiocarbamate) fungicides are degraded and metabolised via a common pathway. The primary degradation reaction of maneb and zineb in water, soil, plants and animals involves the initial dissociation of the metal complex and decomposition to numerous degradation products including ethylenethiourea (ETU) and ethyleneurea (EU) as major products. See zineb and maneb summaries for detailed descriptions.

Shipping

UN2771 Dithiocarbamate and Thiocarbamate pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1- Poisonous materials.

Degradation

Mancozeb (1) was readily hydrolysed in neutral and alkaline solution with DT9 values of 20 days (pH 5), 17 hours (pH 7) and 34 hours (pH 9) (PM). See zineb and maneb summaries for the hydrolytic degradation pathway.

Toxicity evaluation

The mechanism of toxicity for MZ is similar to other EBDC fungicides like maneb. EBDC are able to modify and inactivate redox-sensitive proteins. Because of the thiol reactivity of these compounds, redox-sensitive processes like transcription, translation, and other metabolic processes can be altered, resulting in cytotoxicity. It is due to this multitarget mode of action that MZ and other EBDC compounds are used in fungicide resistance management programs. In contrast to other fungicidal agents, in over 40 years of use, resistance to any of the EBDC compounds has never developed. MZ has also been reported to cause oxidative stress, DNA damage, and apoptosis in rat cells. Additionally, like all EBDC, MZ can act as a chelating agent, allowing it to interfere with enzymes that contain metals which are essential for activity, like dopamine b-hydroxylase.

Incompatibilities

Combustible material. Dust may form explosive mixture in air. Decomposes in temperatures above 170C. Keep away from water, acid, oxidizing materials. Dithiocarbamate esters are combustible. They react violently with powerful oxidizers such as calcium hypochlorite. Poisonous gases are generated by the thermal decomposition of Dithiocarbamate compounds, including carbon disulfide, oxides of sulfur, oxides of nitrogen, hydrogen sulfide, ammonia, and methylamine. Thio and dithiocarbamates slowly decompose in aqueous solution to form carbon disulfide and methylamine or other amines. Such decompositions are accelerated by acids. Flammable gases are generated by the combination of dithiocarbamate with aldehydes, nitrides, and hydrides. Dithiocarbamate are incompatible with acids, peroxides, and acid halides. Corrosive to iron, copper brass, and zinc metals, especially in the presence of moisture. Contact with lime, moisture can cause decomposition. Decomposes on prolonged storage. Degradation produces ethylene thiourea.

Waste Disposal

Disposal Method Suggested: Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number N450, must conform to USEPA regulations for storage, transportation, treatment, and disposal of waste. Dispose of waste material as hazardous waste using a licensed disposal contractor to an approved landfill. Dispose of contents and container to an approved waste disposal plant. Containers must be disposed of properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office. All federal, state, and local environmental regulations must be observed. Do not discharge into drains or sewers. A potential candidate for liquid injection incineration at a temperature range of 650 to 1600C and a residence time 0.1 to 2 seconds. Also, a potential candidate for rotary kiln incineration at a temperature range of 820 to 1600C and residence times of seconds for liquids and gases, and hours for solids.