ChemicalBook > CAS DataBase List > VERRUCULOGEN

VERRUCULOGEN

Product Name
VERRUCULOGEN
CAS No.
12771-72-1
Chemical Name
VERRUCULOGEN
Synonyms
tr1;T1R1;TRXR1;GPR70;TAS1R1;NA 209A;GRIM-12;MGC9145;TR-1TOXIN;VERRUCOLOGEN
CBNumber
CB0294003
Molecular Formula
C27H33N3O7
Formula Weight
511.57
MOL File
12771-72-1.mol
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VERRUCULOGEN Property

Flash point:
2℃
storage temp. 
2-8°C
form 
buffered aqueous solution
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Safety

Hazard Codes 
T,Xn,F
Risk Statements 
23/24/25-36-20/21/22-11
Safety Statements 
36/37/39-45-36/37-26-16
RIDADR 
UN 2811 6.1/PG 2
WGK Germany 
3
RTECS 
JH4920000
HS Code 
38220090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SAB2700535
Product name
Anti-TAS1R1 (N-terminal) antibody produced in rabbit
Purity
affinity isolated antibody, buffered aqueous solution
Packaging
100ul
Price
$368
Updated
2018/11/23
Sigma-Aldrich
Product number
SAB2700382
Product name
Anti-TAS1R1 (C-terminal) antibody produced in rabbit
Purity
affinity isolated antibody, buffered aqueous solution
Packaging
100ul
Price
$368
Updated
2018/11/23
Sigma-Aldrich
Product number
SAB2700382
Product name
Anti-TAS1R1 (C-terminal) antibody produced in rabbit
Purity
affinity isolated antibody, buffered aqueous solution
Packaging
100 μL
Price
$401
Updated
2021/03/22
Sigma-Aldrich
Product number
SAB2700535
Product name
Anti-TAS1R1 (N-terminal) antibody produced in rabbit
Purity
affinity isolated antibody, buffered aqueous solution
Packaging
100 μL
Price
$401
Updated
2021/03/22
Cayman Chemical
Product number
11351
Product name
Verruculogen
Purity
≥95%
Packaging
1mg
Price
$79
Updated
2021/03/22
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VERRUCULOGEN Chemical Properties,Usage,Production

Uses

Verruculogen is a tremorgenic mycotoxin, first isolated from Penicillium verruculosum in 1972. The structure was resolved as an indole alkaloid in 1974. Verruculogen is produced by several species of Penicillium and Aspergillus and its presence is a useful taxonomic phenotypic marker. The tremorgenic action of verruculogen is associated with increases in spontaneous glutamate and aspartate release, decreases in GABA levels and, at toxic doses, an increase in the number and decrease in the affinity of DHP receptors in rat cortex. In in vitro guinea pig ileum preparations, verruculogen causes an increase in contractile responses due to electrical field stimulation, attributed to enhancement of acetylcholine from presynaptic nerve terminals. Verruculogen also inhibits Ca2+-activated K+ channels, and is a cell cycle inhibitor blocking division at the M phase.

Uses

Verruculogen is a tremorgenic mycotoxin isolated from species of Penicillium, Aspergillus, and other fungi. It selectively inhibits the activation of Maxi-K potassium channels by charybdotoxin with a K1/2 value of 170 nM. Verruculogen also promotes the release of excitatory neurotransmitters when injected directly into the brain of rats and, at high doses, arrests mouse mammary carcinoma cells in M phase of the cell cycle (MIC = 12.2 μM).[Cayman Chemical]

Definition

ChEBI: An organic heterohexacyclic compound that is a mycotoxic indole alkaloid isolated from Penicillium and Aspergillus species.

VERRUCULOGEN Preparation Products And Raw materials

Raw materials

Preparation Products

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VERRUCULOGEN Suppliers

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12771-72-1, VERRUCULOGENRelated Search:


  • VERRUCULOGEN
  • VERRUCULOGEN, PENICILLIUM VERRUCULOSUM
  • 3h)-dione,1,10,10a,14,14a,15b-hexahydro-10,10a-dihydroxy-7-methoxy-2,2-dimeth
  • 5h,12h-3,4-dioxa-5a,11a,15a-triazacyclooct(lm)indeno(5,6-b)fluorene-11,15(2h,1
  • tr1
  • verruculogentr1
  • yl-5-(2-methyl-1-propenyl)-,(5r-(5-alpha,10-alpha,10a-alpha,14a-alpha-15b-alp
  • verruculogen from penicillium*verruculosum
  • VERRUCULOGEN FROM PENICILLIUM VERRUCULOS
  • VERRUCOLOGEN
  • TR-1TOXIN
  • (5R)-1,10,10a,14,14aα,15bα-Hexahydro-10α,10aα-dihydroxy-7-methoxy-2,2-dimethyl-5α-(2-methyl-1-propenyl)-12H-3,4-dioxa-5a,11a,15a-triazacyclooct[lm]indeno[5,6-b]fluorene-11,15(2H,13H)-dione
  • (5R)-2,5,10,10a,11,12,13,14,14aα,15bα-Decahydro-10α,10aα-dihydroxy-7-methoxy-2,2-dimethyl-5α-(2-methyl-1-propenyl)-3,4-dioxa-5a,11a,15a-triaza-1H-cyclooct[lm]indeno[5,6-b]fluorene-11,15-dione
  • (5R-(5alpha,10 alpha,10Aalpha,14aalpha,15balpha))-1,10,10A,14,14A,15B-hexahydro-10,10A-dihydroxy-7-methoxy-2,2-dimethyl-5-(2-methyl-1-propenyl)-5H,12H-3,4-dioxa-5A,11A,15A-triaza cyclooct (1m) indeno (5,6-B)fluorene-11,15(2H,13H)-dione
  • 5H,12H-3,4-Dioxa-5A,11A,15A-triazacyclooct(lm)indeno(5,6-B)fluorene-11,15(2H,13H)-dione, 1,10,10A,14,14A,15B-hexahydro-10,10A-dihydroxy-7-methoxy-2,2-dimethyl-5-(2-methyl-1-propenyl)-, (5R,10S,10ar,14as,15bs)-
  • 5H,12H-3,4-Dioxa-5A,11A,15A-triazacyclooct(lm)indeno(5,6-B)fluorene-11,15(2H,13H)-dione, 1,10,10A,14,14A,15B-hexahydro-10,10A-dihydroxy-7-methoxy-2,2-dimethyl-5-(2-methyl-1-propenyl)-,(5R-(5-alpha,10-alpha,10A-alpha,14A-alpha-15B-alpha))-
  • Verruculogenresearch grade
  • NA 209A
  • Verruculogen NA 209A TR 1 toxin
  • Verruculogen solution
  • GRIM-12
  • MGC9145
  • TRXR1
  • TXNRD1 human
  • Anti-TAS1R1 (N-terminal) antibody produced in rabbit
  • GPR70
  • T1R1
  • TAS1R1
  • ANTI-TAS1R1 (CENTER) antibody produced in rabbit
  • Taste receptor type 1 member 1
  • Anti-TAS1R1 (C-terminal) antibody produced in rabbit
  • GWIWVUJHTCZBOP-FCXIIMTCSA-N
  • 5H,12H-3,4-Dioxa-5a,11a,15a-triazacyclooct[lm]indeno[5,6-b]fluorene-11,15(2H,13H)-dione, 1,10,10a,14,14a,15b-hexahydro-10,10a-dihydroxy-7-methoxy-2,2-dimethyl-5-(2-methyl-1-propen-1-yl)-, (5R,10S,10aR,14aS,15bS)-
  • 12771-72-1
  • C27H35N3O7
  • C27H33N3O7
  • antibiotic