Paramethasone

Product Name: Paramethasone
CAS No.: 53-33-8
Chemical Name: Paramethasone
Synonyms: Cortiden;PARAMETHASONE;Picaridin Impurity 9;6a-Fluoro-16a-methylprednisolone;16a-Methyl-6a-fluoroprednisolone;6-alpha-fluoro-16-alpha-methylprednisolone;Methylprednisolone Impurity 30 (Paramethasone);1, 4-PREGNADIEN-6α-FLUORO-16α-METHYL-11β, 17, 21-TRIOL-3, 20-DIONE;6α-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione;6a-fluoro-11b,17a,21-trihydroxy-16a-methyl-1,4-pregnadiene-3,20-dione
CBNumber: CB0301372
Molecular Formula: C22H29FO5
Formula Weight: 392.46
MOL File: 53-33-8.mol

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Paramethasone Property

Melting point:: 228-241°C
Boiling point:: 573.5±50.0 °C(Predicted)
Density: 1.32±0.1 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 12.34±0.70(Predicted)
color: White to Pale Beige
CAS DataBase Reference: 53-33-8

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Safety

Hazardous Substances Data: 53-33-8(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: P191840
Product name: Paramethasone
Packaging: 2.5mg
Price: $185
Updated: 2021/12/16

TRC

Product number: P191840
Product name: Paramethasone
Packaging: 25mg
Price: $1455
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 60958
Product name: Paramethasone
Packaging: 25mg
Price: $2200
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: SHG0007268
Product name: PARAMETHASONE
Purity: 95.00%
Packaging: 5G
Price: $909.56
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: SHG0007268
Product name: PARAMETHASONE
Purity: 95.00%
Packaging: 10G
Price: $1334.03
Updated: 2021/12/16

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Paramethasone Chemical Properties,Usage,Production

Originator

Haldrone,Lilly,US,1961

Uses

Paramethasone, is a fluorinated glucocorticoid, having anti-inflammatory and immunosuppressant properties.

Uses

Glucocorticoid.

Definition

ChEBI: Paramethasone is a fluorinated steroid.

Manufacturing Process

A solution of 0.144 g of the 3-ethylene glycol ketal of 5α,11β,17α,21 tetrahydroxy-6β-fluoro-16α-methylallopregnane-3,20-dione-21 acetate in 12 ml of chloroform and 0.1 ml of absolute alcohol was cooled to -10°C in an icesalt bath and a stream of anhydrous hydrochloric acid was gently bubbled through the solution for 2.5 hours while the temperature was maintained between -5°C and -15°C. The solution was then diluted with 25 ml of chloroform, washed with dilute sodium bicarbonate and water, dried over anhydrous sodium sulfate, and evaporated to dryness under reduced pressure at 60°C or less to give 6α-fluoro-11β,17α,21-trihydroxy-16α-methyl-4-pregnene3,20-dione 21-acetate.

brand name

Haldrone (Lilly).

Therapeutic Function

Glucocorticoid

Paramethasone Preparation Products And Raw materials

Raw materials

Preparation Products

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Paramethasone Suppliers

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53-33-8, ParamethasoneRelated Search:

Methylparaben Bensulfuron methyl Kresoxim-methyl Methyl acrylate BECLOMETHASONE Methyl Methylprednisolone Methyl bromide Fluorine paramethasone21-acetat Prednisolone Dexamethasone Fluocortolone Fluprednisolone Paramethasone PARAMETHASONE AC&Eacute PARAMETHASONE ACETATE USP(CRM STANDARD) PARAMETHASONE ACéTATE FPC(CRM STANDARD)

16a-Methyl-6a-fluoroprednisolone

6a-Fluoro-16a-methylprednisolone

Cortiden

Pregna-1,4-diene-3,20-dione, 6a-fluoro-11b,17,21-trihydroxy-16a-methyl- (8CI)

Pregna-1,4-diene-3,20-dione, 6a-fluoro-11b,17,21-trihydroxy-16-methyl- (7CI)

Pregna-1,4-diene-3,20-dione, 6-fluoro-11,17,21-trihydroxy-16-methyl-, (6a,11b,16a)- (9CI)

(6S,8S,9S,10R,11S,13S,14S,16R,17R)-6-Fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one

6α-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione

PARAMETHASONE

6a-fluoro-11b,17a,21-trihydroxy-16a-methyl-1,4-pregnadiene-3,20-dione

6-alpha-fluoro-11-beta,17-alpha,21-trihydroxy-16-alpha-methylpregna-1,4-diene-3,20-dione

6-alpha-fluoro-16-alpha-methylprednisolone

1,4-PREGNADIEN-6-ALPHA-FLUORO-16-ALPHA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE

(6S,8S,9S,10R,11S,13S,14S,16R,17R)-6-fluoro-11,17-dihydroxy-17-(2-hydroxyethanoyl)-10,13,16-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one

(6S,8S,9S,10R,11S,13S,14S,16R,17R)-6-fluoro-17-glycoloyl-11,17-dihydroxy-10,13,16-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one

6-fluoro-11,17-dihydroxy-17-(2-hydroxy-1-oxoethyl)-10,13,16-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one

Pregna-1,4-diene-3,20-dione, 6-fluoro-11,17,21-trihydroxy-16-methyl-, (6α,11β,16α)-

Pregna-1,4-diene-3,20-dione,6-fluoro-11,17,21-trihydroxy-16-methyl-, (6a,11b,16a)-

Methylprednisolone Impurity 30 (Paramethasone)

Picaridin Impurity 9

1, 4-PREGNADIEN-6α-FLUORO-16α-METHYL-11β, 17, 21-TRIOL-3, 20-DIONE

53-33-8