ChemicalBook > CAS DataBase List > Mal-Amido-PEG4-acid

Mal-Amido-PEG4-acid

Product Name
Mal-Amido-PEG4-acid
CAS No.
1263045-16-4
Chemical Name
Mal-Amido-PEG4-acid
Synonyms
BMPA-PEG4-Acid;Mal-NH-PEG4-COOH;Mal-NH-PEG4-acid;Mal-Amido-PEG4-acid;MAL-AMIDO-PEG4-COOH;Mal-dPEG4-CH2CH2COOH;Mal-NH-PEG4-CH2CH2COOH;MAL-dPEG??-acid (QBD-10338);Maleimide-NH-PEG4-CH2CH2COOH;Mal-amido-PEG4-propionic acid
CBNumber
CB03062522
Molecular Formula
C18H28N2O9
Formula Weight
416.42
MOL File
1263045-16-4.mol
More
Less

Mal-Amido-PEG4-acid Property

Boiling point:
659.1±55.0 °C(Predicted)
Density 
1.270±0.06 g/cm3(Predicted)
storage temp. 
-20°C, protect from light
solubility 
Soluble in Water, DMSO, DMF, DCM
pka
4.28±0.10(Predicted)
form 
powder to crystal
color 
White to Gray to Brown
InChI
InChI=1S/C18H28N2O9/c21-15(3-6-20-16(22)1-2-17(20)23)19-5-8-27-10-12-29-14-13-28-11-9-26-7-4-18(24)25/h1-2H,3-14H2,(H,19,21)(H,24,25)
InChIKey
IAJVEYLYYHOZEY-UHFFFAOYSA-N
SMILES
C(O)(=O)CCOCCOCCOCCOCCNC(=O)CCN1C(=O)C=CC1=O
CAS DataBase Reference
1263045-16-4
More
Less

Safety

HS Code 
3822000000
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

More
Less

N-Bromosuccinimide Price

TCI Chemical
Product number
M2666
Product name
19-Maleimido-17-oxo-4,7,10,13-tetraoxa-16-azanonadecanoic Acid
Purity
>95.0%(HPLC)
Packaging
25mg
Price
$55
Updated
2025/07/31
TCI Chemical
Product number
M2666
Product name
19-Maleimido-17-oxo-4,7,10,13-tetraoxa-16-azanonadecanoic Acid
Purity
>95.0%(HPLC)
Packaging
100mg
Price
$154
Updated
2025/07/31
TRC
Product number
M157503
Product name
19-Maleimido-17-oxo-4,7,10,13-tetraoxa-16-azanonadecanoic Acid
Packaging
50mg
Price
$60
Updated
2021/12/16
Chem-Impex
Product number
39665
Product name
19-Maleimido-17-oxo-4,7,10,13-tetraoxa-16-azanonadecanoicacid,95%(HPLC)
Purity
95%(HPLC)
Packaging
25MG
Price
$63.84
Updated
2021/12/16
dPEG
Product number
10338
Product name
MAL-dPEG®₄-acid
Packaging
1000mg
Price
$125
Updated
2021/12/16
More
Less

Mal-Amido-PEG4-acid Chemical Properties,Usage,Production

Description

Mal-amido-PEG4-acid is a PEG linker containing a maleimide group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.

Uses

Mal-amido-PEG4-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005

Mal-Amido-PEG4-acid Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Mal-Amido-PEG4-acid Suppliers

Americas 1 China 80 Europe 1 India 1 Japan 1 United Kingdom 1 United States 8 Global 93
TCI Europe
Tel
320-37350700
Fax
+32 (0)37350701
Email
sales@tcieurope.eu
Country
Europe
ProdList
23671
Advantage
75
More
Less

View Lastest Price from Mal-Amido-PEG4-acid manufacturers

LAURENT
Product
Mal-NH-PEG4-CH2CH2COOH 1263045-16-4
Price
US $465.00/g
Min. Order
1g
Purity
98%
Supply Ability
300kg
Release date
2025-11-15
Xian confluore Biological Technology Co., Ltd.
Product
Mal-amido-PEG4-acid 1263045-16-4
Price
US $0.00/g
Min. Order
1g
Purity
>98.00%
Supply Ability
1g
Release date
2024-03-27

1263045-16-4, Mal-Amido-PEG4-acidRelated Search:

alpha-MaleiMidopropionyl-oMega-succiniMidyl-10(ethylene glycol) alpha-MaleiMidopropionyl-oMega-succiniMidyl-6(ethylene glycol) Mal-PEG2-amine Mal-PEG3-NHS ester Mal-PEG6-COOH N-Succinimidyl 3-maleimidopropionate Mal-PEG4-NHS ester 3,4-Dibromo-Mal-PEG2-Amine Maleimido-Tri(Ethylene Glycol)-Propionic Acid Mal-PEG2-COOH N-[4-(-Carboxycyclohexylmethyl)]maleimide Mal-PEG4-Acid Mal-PEG2-NHS ester Bis-Mal-Lysine-PEG4-TFP ester Maleimide-PEG4-NHS Ester Maleimide-PEG2-NHS Ester 3-Maleimidopropionic acid Mal-PEG2-acid

  • Mal-CH2CH2CONH-PEG4-CH2CH2COOH
  • 1-[3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido]-3,6,9,12-tetraoxapentadecan-15-oic acid
  • 19-Maleimido-17-oxo-4,7,10,13-tetraoxa-16-azanonadecanoic Acid
  • Maleimide-NH-PEG4-CH2CH2COOH
  • Maleimide-PEG4-propionic acid
  • MAL-AMIDO-PEG4-COOH
  • Mal-NH-PEG4-COOH
  • Mal-Amido-PEG4-acid
  • Mal-NH-PEG4-acid
  • 4,7,10,13-Tetraoxa-16-azanonadecanoic acid, 19-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-17-oxo-
  • Mal-amido-PEG4-propionic acid
  • 1-Maleimido-3-oxo-7,10,13,16-tetraoxa-4-azanonadecan-19-oic Acid
  • 1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-oxo-7,10,13,16-tetraoxa-4-azanonadecan-19-oic acid
  • BMPA-PEG4-Acid
  • Mal-CH2CH2CONH-PEG4-CH2CH2COOH/4,7,10,13-Tetraoxa-16-azanonadecanoic acid, 19-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-17-oxo-
  • 3-[2-[2-[2-[2-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
  • Mal-dPEG4-CH2CH2COOH
  • MAL-dPEG??-acid (QBD-10338)
  • 3-Amino(peg4)propionic acid 3-maleimidopropionamide
  • Mal-NH-PEG4-CH2CH2COOH
  • 1263045-16-4
  • C18H28N2O9
  • peg