OLOMOUCINE

Product Name: OLOMOUCINE
CAS No.: 101622-51-9
Chemical Name: OLOMOUCINE
Synonyms: OLOMOUCINE;NSC 666096;Olomoucine,highpurity;OLOMOUCINE SYNTHETIC >95%;Olomoucine,98%,high purity;N2-[(2-HYDROXYETHYL)]-N6-BENZYLADENINE;Olomoucine - CAS 101622-51-9 - Calbiochem;5-Bromo-21-fluorobenzylamine&hydrochloride;2-(hydroxyethylamino)-6-benzylamino-9-methylpurine;6-BENYLAMINO-2-(2-HYDROXYETHYLAMINO)-9-METHYLPURINE
CBNumber: CB0309080
Molecular Formula: C15H18N6O
Formula Weight: 298.34
MOL File: 101622-51-9.mol

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OLOMOUCINE Property

Melting point:: 120-130 °C
Boiling point:: 579.6±60.0 °C(Predicted)
Density: 1.36
storage temp.: -20°C
solubility: DMSO, Methanol (Slightly)
form: Solid
pka: 14.55±0.10(Predicted)
color: White to off-white
CAS DataBase Reference: 101622-51-9(CAS DataBase Reference)

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Safety

Safety Statements: 24/25
WGK Germany: 3
HS Code: 29339980

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 495620
Product name: Olomoucine
Packaging: 1mg
Price: $71.1
Updated: 2024/03/01

Sigma-Aldrich

Product number: 495620
Product name: Olomoucine
Packaging: 5mg
Price: $272
Updated: 2024/03/01

Cayman Chemical

Product number: 10010240
Product name: Olomoucine
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 10010240
Product name: Olomoucine
Purity: ≥98%
Packaging: 5mg
Price: $70
Updated: 2024/03/01

Sigma-Aldrich

Product number: O0886
Product name: Olomoucine
Purity: ≥98% (HPLC)
Packaging: 1mg
Price: $87.5
Updated: 2024/03/01

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OLOMOUCINE Chemical Properties,Usage,Production

Chemical Properties

white to off-white solid

Uses

A purine derivative which inhibits cyclin-dependent kinases and induces G1 arrest.

Definition

ChEBI: Olomoucine is a 9H-purine that is substituted by a (2-hydroxyethyl)nitrilo, benzylnitrilo and a methyl group at positions 2,6 and 9, respectively. It is a cyclin-dependent kinase inhibitor. It has a role as an EC 2.7.11.22 (cyclin-dependent kinase) inhibitor. It is a member of 2,6-diaminopurines and a member of ethanolamines.

Biological Activity

Cyclin-dependent kinase inhibitor that competes for the ATP binding site of the kinase. Selectively inhibits cdc2/cyclin B (IC 50 = 7 μ M), cdk2/cyclin A (IC 50 = 7 μ M), cdk2/cyclin E (IC 50 = 7 μ M), cdk/p35 kinase (IC 50 = 3 μ M)? and ERK1/MAP kinase (IC 50 = 25 μ M). Arrests human fibroblasts in the G1 phase.

Biochem/physiol Actions

Olomoucine is a purine derivative which inhibits cyclin-dependent kinases and induces G arrest.

Enzyme inhibitor

This ATP site-competitive purine derivative (FW = 298.35 g/mol; CAS 101622-51-9), systematically named 6-benzylamino-2-[2-hydroxyethylamino]- 9-methylpurine, is a potent inhibitor of cyclin-dependent kinases, with an IC50 value of 7 μM for both cdk1 and cdk2 and an IC50 value of 3 μM for cdk5, arresting cells in G1. Olomoucine also inhibits cytokinin 7b-glucosyltransferase.

References

[1]. vesel j, havlicek l, strnad m, et al. inhibition of cyclin-dependent kinases by purine analogues. eur j biochem. 1994 sep 1;224(2):771-86.
[2]. abraham rt, acquarone m, andersen a, et al. cellular effects of olomoucine, an inhibitor of cyclin-dependent kinases. biol cell. 1995;83(2-3):105-20.
[3]. tian ds, xie mj, yu zy, et al. cell cycle inhibition attenuates microglia induced inflammatory response and alleviates neuronal cell death after spinal cord injury in rats. brain res. 2007 mar 2;1135(1):177-85.

OLOMOUCINE Preparation Products And Raw materials

Raw materials

Preparation Products

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OLOMOUCINE Suppliers

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View Lastest Price from OLOMOUCINE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: OLOMOUCINE 101622-51-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

101622-51-9, OLOMOUCINERelated Search:

SU 9516 NU6102 6-Benzylaminopurine PURVALANOL A OLOMOUCINE II 2(BIS-(HYDROXYETHYL)AMINO)-6-(4-METHOXYBENZYLAMINO)-9-ISOPROPYL-PURINE AMINOPURVALANOL A ARCYRIAFLAVIN A Roscovitine SELICICLIB (S)-ROSCOVITINE OLOMOUCINE, N9-ISOPROPYL-,N9-ISOPROPYL-OLOMOUCINE OLOMOUCINE ISO-OLOMOUCINE,OLOMOUCINE, ISO- OLOMOUCINE, DIMETHYLAMINO,DIMETHYLAMINO-OLOMOUCINE OLOMOUCINE (DRY ICE) N-G-PROPYL OLOMOUCINE OLOMOUCINE II

6-BENYLAMINO-2-(2-HYDROXYETHYLAMINO)-9-METHYLPURINE

6-BENZYLAMINO-2-(2-HYDROXYETHYLAMINO)-9-METHYLPURINE

2-(2'-Hydroxyethylamino)-9-methyl-6-(benzylamino)purine

2-(hydroxyethylamino)-6-benzylamino-9-methylpurine

2-[[9-METHYL-6[(PHENYLMETHYL)AMINO]-9H-PURIN-2-YL]AMINO]-ETHANOL

2-(2-HYDROXYETHYLAMINO)-6-BENZYLAMINO-9-METHYLPURINE

N2-[(2-HYDROXYETHYL)]-N6-BENZYLADENINE

OLOMOUCINE

OLOMOUCINE SYNTHETIC >95%

Olomoucine,highpurity

Olomoucine - CAS 101622-51-9 - Calbiochem

2-[(2-Hydroxyethyl)amino]-6-benzylamino-9-methyl-9H-purine

2-[[9-Methyl-6-(benzylamino)-9H-purine-2-yl]amino]ethanol

N-(2-Hydroxyethyl)-N'-benzyl-9-methyl-9H-purine-2,6-diamine

Olomoucine,98%,high purity

Olomoucine6-Benzylamino-2-(2-hydroxyethylamino)-9-methylpurine

2-(6-Benzylamino-9-methyl-9H-purin-2-ylamino)-ethanol Olomoucine

NSC 666096

2-((6-(Benzylamino)-9-methyl-9H-purin-2-yl)amino)ethanol

Ethanol, 2-[[9-methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-

5-Bromo-21-fluorobenzylamine&hydrochloride

Olomoucine,Inhibitor,cyclindependent kinases,cdc2,purines,cell cycle,non-small cell lung cancer cell line,MR6.5,protein kinases,Cyclin dependent kinase,CDK,xenopus laevis oocytes,proliferation,inhibit,cdk2

101622-51-9

C15H18N6O

Cell Signaling and Neuroscience

Cell Cycle Regulators

Cell Cycle

Cell Biology

Apoptosis and Cell Cycle

BioChemical

Heterocyclic Compounds

Bases & Related Reagents

Heterocycles

Inhibitors

inhibitor

Nucleotides

Protein Kinase