GSK-3326595
- Product Name
- GSK-3326595
- CAS No.
- 1616392-22-3
- Chemical Name
- GSK-3326595
- Synonyms
- GSK3326595;6-[(1-acetylpiperidin-4-yl)amino]-N-[(2S)-2-hydroxy-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]pyrimidine-4-carboxamide;EPZ-015938;GSK-3326595,EPZ-015938;EPZ-015938 (GSK3326595);EPZ015938(pemrametostat);Pemrametostat (GSK3326595);EPZ015938; EPZ 015938; EPZ-015938;Pemrametostat, GSK3326595, EPZ015938;6-[(1-acetylpiperidin-4-yl)amino]-N-[(2S)-2-hydroxy-3-(1
- CBNumber
- CB03121890
- Molecular Formula
- C24H32N6O3
- Formula Weight
- 452.55
- MOL File
- 1616392-22-3.mol
GSK-3326595 Property
- Boiling point:
- 760.3±60.0 °C(Predicted)
- Density
- 1.275±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- Soluble in DMSO (up to 20 mg/ml).
- pka
- 12.44±0.46(Predicted)
- form
- solid
- color
- Off-white
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 27305
- Product name
- GSK3326595
- Packaging
- 5mg
- Price
- $116
- Updated
- 2024/03/01
- Product number
- 27305
- Product name
- GSK3326595
- Packaging
- 25mg
- Price
- $343
- Updated
- 2024/03/01
- Product number
- 27305
- Product name
- GSK3326595
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 27305
- Product name
- GSK3326595
- Packaging
- 10mg
- Price
- $199
- Updated
- 2024/03/01
- Product number
- CS-6451
- Product name
- GSK3326595
- Purity
- 99.55%
- Packaging
- 50mg
- Price
- $250
- Updated
- 2021/12/16
GSK-3326595 Chemical Properties,Usage,Production
Description
GSK3326595 (1616395-22-3) is a potent (IC50?= 6.2nM), selective (>4000-fold over 20 other methyltransferases), SAM uncompetitive, peptide competitive inhibitor of PRMT5.1?PRMT5 inhibition activated the p53 pathway?via?induction of alternative splicing of MDM4 leading to a potent anti-proliferative response both?in vitro?and?in vivo. Combination therapy with palbociclib (CDK4/6 inhibitor, Focus Cat.# 10-4760) and GSK3326595 lead to increased efficacy of palbociclib in treating native and resistant models of melanoma via regulation of the PRMT5-MDM4 axis.2?Currently in clinical trials.3
Uses
GSK-3326595 is a protein arginine methyltransferase 5(PRMT5) inhibitor under clinical trial.
References
1) Gerhart?et al.?(2018),?Activation of the p53-MDM4 regulatory axis defines the anti-tumor response to PRMT5 inhibition through its role in regulating cellular splicing; Sci. Rep.?8?9711 2) AbuHammad?et al.?(2019),?Regulation of PRMT5-MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma; Proc. Natl. Acad. Sci. USA?116?179909 3) NCT02783300
GSK-3326595 Preparation Products And Raw materials
Raw materials
Preparation Products
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