Rucaparib Camsylate

Product Name: Rucaparib Camsylate
CAS No.: 1859053-21-6
Chemical Name: Rucaparib Camsylate
Synonyms: Rucaparib Camsylate;Asciminib Impurity 1;Rucaparib monocamsylate;Rucaparib Camphosulfonate;Rucaparib monocamsylate, 10 mM in DMSO;6-fluoro-2-[4-(methylaminomethyl)phenyl]-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4,6,8(13)-tetraen-9-one;8‐Fluoro‐2‐(4‐methylaminomethyl‐phenyl)‐1,3,4,5‐tetrahydro‐azepino[5,4,3‐cd] indol‐6‐one (S)‐camphorsulfonate Salt;8-Fluoro-5-(4-((methylamino)methyl)phenyl)-2,3,4,6-tetrahydro-1H-azepino[5,4,3-cd]indol-1-one ((1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonate;8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H- azepino[5,4,3-cd]indol-6-one ((1S,4R)-7,7dimethyl-2-oxobicyclo [2.2.1] hept-1-yl) methanesulfonic acid salt;Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-, (1S,4R)-, compd. with 8-fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one (1:1)
CBNumber: CB03147535
Molecular Formula: C29H34FN3O5S
Formula Weight: 555.67
MOL File: 1859053-21-6.mol

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Rucaparib Camsylate Property

storage temp.: Store at -20°C
solubility: DMSO:79.63(Max Conc. mg/mL);143.31(Max Conc. mM)
form: Solid
color: Light yellow to gray

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H341Suspected of causing genetic defects

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PZ0036
Product name: Rucaparib camsylate
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $108
Updated: 2025/07/31

Sigma-Aldrich

Product number: PZ0036
Product name: Rucaparib camsylate
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $436
Updated: 2025/07/31

Tocris

Product number: 6230
Product name: Rucaparibcamsylate
Purity: ≥98%(HPLC)
Packaging: 10
Price: $133
Updated: 2021/12/16

TRC

Product number: R701585
Product name: RucaparibCamsylate
Packaging: 10mg
Price: $115
Updated: 2021/12/16

ChemScene

Product number: CS-6939
Product name: Rucaparib(Camsylate)
Purity: 99.92%
Packaging: 5mg
Price: $84
Updated: 2021/12/16

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Rucaparib Camsylate Chemical Properties,Usage,Production

Uses

Rucaparib Camsylate is a novel DNA repair enzyme poly-ADP ribose polymerase-1 (PARP-1) inhibitor.

Definition

ChEBI: Rucaparib camsylate is a camphorsulfonate salt obtained by reaction of rucaparib with one molar equivalent of (1S,4R)-camphorsulfonic acid. It is an inhibitor of poly (ADP-ribose) polymerase and is used as monotherapy for advanced ovarian cancer and deleterious germline or somatic BRCA mutation. It has a role as an EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor. It is a camphorsulfonate salt and an azepinoindole. It contains a (S)-camphorsulfonate and a rucaparib(1+).

Biological Activity

Rucaparib is an inhibitor of the DNA repair enzyme poly-ADP ribose polymerase-1 (PARP-1). It has been found to have anticancer activity in a number of cancers and has been approved for treatment of previously treated, BRCA-mutant ovarian cancer.

in vivo

Rucaparib (AG014699) monocamsylate and AG14584 significantly increase Temozolomide toxicity. Rucaparib (1 mg/kg) monocamsylate significantly increases Temozolomide-induced body weight loss. Rucaparib (0.1 mg/kg) monocamsylate results in a 50% increase in the temozolomide-induced tumor growth delay^[1].
Rucaparib (10 mg/kg for i.p. or 50, 150 mg/kg for p.o.; daily for 5 days per week for 6 weeks) monocamsylate significantly inhibits the growth of the tumor, and there is one complete tumor regression and two persistent partial regressions^[2].
Rucaparib (150 mg/kg; p.o.; once per week for 6 weeks or three times per week for 6 weeks) monocamsylate has greatest antitumor effect with three complete regressions^[2].
Rucaparib monocamsylate enhances the antitumor activity of temozolomide and indicates complete and sustained tumor regression in NB1691 and SHSY5Y xenografts^[6].

Animal Model:	Female CD-1 nude mice aged 10-12 weeks with Capan-1 cells^[2]
Dosage:	10?mg/kg or 50, 150 mg/kg
Administration:	10?mg/kg for i.p. or 50, 150 mg/kg for p.o.
Result:	Significantly inhibited the growth of the tumor.

IC 50

PARP-1: 1.4 nM (Ki); PARP-2; PARP-3

storage

Store at -20°C

Rucaparib Camsylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Rucaparib Camsylate Suppliers

China 106 India 4 United Kingdom 1 United States 6 USA 1 Global 118

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ShangHai Biochempartner Co.,Ltd

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View Lastest Price from Rucaparib Camsylate manufacturers

Wuhan JiyunZen Tech Co., Ltd.

Product: Rucaparib Camsylate 1859053-21-6
Price: US $5.00-0.50/KG
Min. Order: 1KG
Purity: 99% hplc
Supply Ability: 500TONS
Release date: 2025-05-14

Henan Aochuang Chemical Co.,Ltd.

Product: Rucaparib Camsylate 1859053-21-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-30

Shaanxi Dideu New Materials Co. Ltd

Product: Rucaparib Camsylate 1859053-21-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-02-19

1859053-21-6, Rucaparib CamsylateRelated Search:

DL-CAMPHORIC ANHYDRIDE (+/-)-EXO EXO-2 3-CAMPHANEDIOL (+)-10-CAMPHORSULFONIMINE (-)-(8,8-DICHLOROCAMPHORYLSULFONYL)OXAZIRIDINE (1S)-(+)-Camphor-10-sulphonic acid (1R)-(-)-10-Camphorsulfonic acid L(-)-10-Camphorsulfonyl chloride D-CAMPHOR (+)-(8,8-DICHLOROCAMPHORYLSULFONYL)OXAZIRIDINE (7,7-DIMETHYL-2-OXO-BICYCLO[2.2.1]HEPT-1-YL)-METHANESULFONYL CHLORIDE EUROPIUM D-3-TRIFLUOROACETYLCAMPHORATE EUROPIUM TRIS[3-(HEPTAFLUOROPROPYLHYDROXYMETHYLENE)-(+)-CAMPHORATE] PF-01367338 (-)-3-(Trifluoroacetyl)camphor (2S)-Bornane-10,2-sultam [(1S)-ENDO]-(+)-3-BROMO-10-CAMPHORSULFONIC ACID MONOHYDRATE Rucaparib (1S)-(-)-Camphorsulfonylimine

Rucaparib Camsylate

8‐Fluoro‐2‐(4‐methylaminomethyl‐phenyl)‐1,3,4,5‐tetrahydro‐azepino[5,4,3‐cd] indol‐6‐one (S)‐camphorsulfonate Salt

Rucaparib Camphosulfonate

Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-, (1S,4R)-, compd. with 8-fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one (1:1)

8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H- azepino[5,4,3-cd]indol-6-one ((1S,4R)-7,7dimethyl-2-oxobicyclo [2.2.1] hept-1-yl) methanesulfonic acid salt

Rucaparib monocamsylate

8-Fluoro-5-(4-((methylamino)methyl)phenyl)-2,3,4,6-tetrahydro-1H-azepino[5,4,3-cd]indol-1-one ((1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonate

Asciminib Impurity 1

Rucaparib monocamsylate, 10 mM in DMSO

6-fluoro-2-[4-(methylaminomethyl)phenyl]-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4,6,8(13)-tetraen-9-one

1859053-21-6

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