L-Camphorsulfonic acid Chemical properties Uses Production method
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(1R)-(-)-10-Camphorsulfonic acid

L-Camphorsulfonic acid Chemical properties Uses Production method
Product Name
(1R)-(-)-10-Camphorsulfonic acid
CAS No.
35963-20-3
Chemical Name
(1R)-(-)-10-Camphorsulfonic acid
Synonyms
(-)-CSA;(-)-10-CSA;(-)-CamphorsuL;(-)-CamphorsuL;L(-)-Camphorsulfonic;Camphor-sulphonicacid;(R)-camphorsulfonicaci;L-CAMPHORSULPHONIC ACID;CLOPIDOGREL INTERMEDIATES;L-(-)-CAMPHORSULFONIC ACID
CBNumber
CB0365888
Molecular Formula
C10H16O4S
Formula Weight
232.3
MOL File
35963-20-3.mol
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(1R)-(-)-10-Camphorsulfonic acid Property

Melting point:
198 °C (dec.)(lit.)
alpha 
-22 º (c=20,H2O)
Boiling point:
344.46°C (rough estimate)
Density 
1.2981 (rough estimate)
refractive index 
-21.5 ° (C=5, H2O)
storage temp. 
2-8°C
pka
1.17±0.50(Predicted)
form 
Crystalline Powder
color 
White to slightly beige
PH
1.2-1.4 (20g/l, H2O)
optical activity
[α]20/D 21°, c = 2 in H2O
Water Solubility 
soluble
Sensitive 
Hygroscopic
BRN 
2809676
Stability:
Stable. Hygroscopic. Incompatible with strong bases, strong oxidizing agents.
InChIKey
MIOPJNTWMNEORI-XVKPBYJWSA-N
CAS DataBase Reference
35963-20-3(CAS DataBase Reference)
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Safety

Hazard Codes 
C
Risk Statements 
34
Safety Statements 
26-36/37/39-45-24/25-27
RIDADR 
UN 3261 8/PG 2
WGK Germany 
3
3-10
TSCA 
Yes
HazardClass 
8
PackingGroup 
III
HS Code 
29147090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H290May be corrosive to metals

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

Precautionary statements

P234Keep only in original container.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P310Immediately call a POISON CENTER or doctor/physician.

P390Absorb spillage to prevent material damage.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

P406Store in corrosive resistant/… container with a resistant inner liner.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
21365
Product name
(?)-Camphor-10-sulfonic acid
Purity
purum, ≥98.0% (T)
Packaging
50g-f
Price
$76.4
Updated
2020/08/18
Sigma-Aldrich
Product number
8.40094
Product name
(1R)-(-)-Camphor-10-sulfonic acid
Purity
for synthesis
Packaging
100 g
Price
$130.42
Updated
2021/03/22
Sigma-Aldrich
Product number
21365
Product name
(?)-Camphor-10-sulfonic acid
Purity
purum, ≥98.0% (T)
Packaging
250g-f
Price
$265
Updated
2020/08/18
Sigma-Aldrich
Product number
1718063
Product name
Voriconazole Related Compound F
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
50 mg
Price
$1160
Updated
2021/03/22
TCI Chemical
Product number
C0972
Product name
(-)-10-Camphorsulfonic Acid
Purity
>98.0%(T)
Packaging
25g
Price
$18
Updated
2021/03/22
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(1R)-(-)-10-Camphorsulfonic acid Chemical Properties,Usage,Production

L-Camphorsulfonic acid

Camphor sulfonic acid includes L-camphor sulfonic acid, D-camphor sulfonic acid and racemic camphor sulfonic acid these three isomers.
It is a kind of white columnar crystals with the melting point of 193°C (decomposition). [α]D20+24° (water). It is Slightly soluble in ethanol, insoluble in ether, soluble in sodium hydroxide and sodium carbonate solution. L-camphor sulfonic acid could be produced from reaction between camphor, sulfuric acid and acetic anhydride.It has a lot of functions such as exciting the respiratory center, the vascular movement center and myocardium. Its sodium salt plays pharmaceutical role in medicine.
Camphor sulfonic acid sodium salt is a kind of white crystalline powder. It is odorless and tastes bitter and then sweet. It is easily absorb moisture and easily dissolve in the water and hot ethanol. So it should be shading confined preservation. it can Directly excite the medulla oblongata respiratory center and vascular movement center, and quicken and deepen the breath, rise the blood pressure; it also can directly excite the myocardium and strength the contraction of cardiac muscle as well as could increase the output.
It is applied the treatment of infectious disease, as well as the disease like central inhibition of poisoning caused by respiratory depression, fatigue, high fever, poisoning, heat stroke and other acute heart failure.

Chemical properties

It is a kind of prismatic crystals and its melting point is 193-195 ° C (decompose). It is Insoluble in ether and slightly soluble in glacial acetic acid and ethyl acetate. And it is and moisture in wet air.

Uses

(1) It is also used for the racemization of optical isomers.
(2) It can be applied to the resolution of intermediate or isomer in medicine.
(3) It also could play a role as organic synthesis intermediates and resolving agent.

Production method

Camphor sulfonic acid is obtained from camphor and sulfuric acid by irradiation.
This method involves:
1) Adding the camphor and acetic anhydride to the pot.
2) Mixing it and making it dissolved.
3) Dripping sulfuric acid after cooling. And the reaction should be maintained at 44-45 °C for 48 hours. Then cool it to 6-7 °C.
4) Crystallizing, filtrating, washing with a small amount of acetic acid crystals, and dry it to get camphor sulfonic acid.

Chemical Properties

white to light yellow crystal powde

Uses

1R)-(-)-10-Camphorsulfonic acid is a chiral derivative of Camphor.It has the following uses:
(1)It is also used for the racemization of optical isomers.
(2) It can be applied to the resolution of intermediate or isomer in medicine.
(3) It also could play a role as organic synthesis intermediates and resolving agent.

Definition

ChEBI: The R enantiomer of camphorsulfonic acid.

Purification Methods

It forms prisms from AcOH or EtOAc, and is deliquescent in moist air. Store it in tightly stoppered bottles. The NH4 salt forms needles from H2O [] D ±20.5o (c 5, H2O). [Burgess & Lowry J Chem Soc 127 279 1925, Marsi et al. J Am Chem Soc [ 78 3063 1956.] The RS-acid recrystallises from AcOH. [60g of (±)-acid in 60mL of AcOH at 105o gave 40g of crystals has m 202-203o [Bartlett & Knox Org Synth 45 12 1965.] [Beilstein 11 IV 642.]

(1R)-(-)-10-Camphorsulfonic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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(1R)-(-)-10-Camphorsulfonic acid Suppliers

Hebei zeshuo pharmaceutical technology co. LTD
Tel
0319-4869289-
Email
export@zeshuobiotec.com
Country
China
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Lihe Wuhan New Chemical Materials Co., Ltd.
Tel
027-88395709,15071332665
Fax
027-88391805
Email
gjing@51chemall.com
Country
China
ProdList
430
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Beijing Bainiannuan Sci.&Tec. Co., Ltd
Tel
10-51765162
Fax
+86-10-51765262
Email
marymeng@bdnchem.com
Country
China
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Lihe Wuhan New Chemical Materials Co., Ltd.
Tel
027-88395717;18171232964 QQ 3344947379
Fax
027-88391805
Email
lling@51chemall.com
Country
China
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Shanghai Hongbang Pharmaceutical Co., Ltd.
Tel
021-24280809-
Fax
021-24280809
Email
1377976036@qq.com;
Country
China
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Wuhan Yidu Shangpai Pharmaceutical Chemical Co., Ltd.
Tel
027-87371123
Fax
027-87371123
Email
yidushangpai@163.com
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China
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Shouguang Jiasheng Chemical Co., Ltd.
Tel
0536-7971999- ;0536-7971999- ;536-7971999-
Fax
0536-7971999
Email
sgjiasheng@hotmail.com;sgjiasheng@hotmail.com;sgjiasheng@hotmail.com
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China
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Hubei Baidu Chemical Co., Ltd
Tel
027-59223020- ;027-59223020-
Fax
027-59223020
Email
1438180055@qq.com;1438580055@qq.com
Country
China
ProdList
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Weifang luze new material co., ltd
Tel
Email
2332680879@qq.com
Country
China
ProdList
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Shanghai Boyle Chemical Co., Ltd.
Tel
Mr Qiu:021-50182298(Demestic market) Miss Xu:021-50180596(Abroad market)
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2213
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View Lastest Price from (1R)-(-)-10-Camphorsulfonic acid manufacturers

career henan chemical co
Product
L(-)Camphor Sulfonic Acid 35963-20-3
Price
US $100.00-90.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg/month or Customized
Release date
2018-07-25

35963-20-3, (1R)-(-)-10-Camphorsulfonic acidRelated Search:


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