Description Uses Dosage Interactions Side Effects Warning
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Camphor

Description Uses Dosage Interactions Side Effects Warning
Product Name
Camphor
CAS No.
76-22-2
Chemical Name
Camphor
Synonyms
Camphor;camphre;Kampfer;lphanon;Formosa;Caladryl;Radian B;Alphanon;2-CAMPHOR;2-Kamfanon
CBNumber
CB7159844
Molecular Formula
C10H16O
Formula Weight
152.23
MOL File
76-22-2.mol
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Camphor Property

Melting point:
175-177 °C(lit.)
Boiling point:
204 °C(lit.)
Density 
0.992
vapor density 
5.2 (vs air)
vapor pressure 
4 mm Hg ( 70 °C)
FEMA 
4513 | dl-CAMPHOR
refractive index 
1.5462 (estimate)
Flash point:
148 °F
storage temp. 
Store below +30°C.
solubility 
Soluble in acetone, ethanol, diethylether, chloroform and acetic acid.
form 
neat
explosive limit
0.6-4.5%(V)
optical activity
[α]20/D +0.15 to -0.15°, c = 10% in ethanol
Water Solubility 
0.12 g/100 mL (25 ºC)
JECFA Number
2199
Merck 
14,1732
BRN 
1907611
Henry's Law Constant
(x 10-5 atm?m3/mol): 3.00 at 20 °C (approximate - calculated from water solubility and vapor pressure)
Exposure limits
TLV-TWA 12 mg/m3 (2 ppm), STEL 18 mg/m3 (3 ppm) (ACGIH); IDLH 200 mg/m3 (NIOSH). .
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents, metallic salts, combustible materials, organics.
InChIKey
DSSYKIVIOFKYAU-MHPPCMCBSA-N
CAS DataBase Reference
76-22-2(CAS DataBase Reference)
NIST Chemistry Reference
Camphor(76-22-2)
EPA Substance Registry System
Camphor (76-22-2)
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Safety

Hazard Codes 
F,Xn,Xi
Risk Statements 
11-22-36/37/38-20/21/22
Safety Statements 
16-26-37/39
RIDADR 
UN 2717 4.1/PG 3
WGK Germany 
1
RTECS 
EX1225000
Autoignition Temperature
870 °F
TSCA 
Yes
HazardClass 
4.1
PackingGroup 
III
HS Code 
29142910
Hazardous Substances Data
76-22-2(Hazardous Substances Data)
Toxicity
LD50 orally in mice: 1.3 g/kg (PB293505)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H228Flammable solid

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

H360May damage fertility or the unborn child

H370Causes damage to organs

H371May cause damage to organs

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P307+P311IF exposed: call a POISON CENTER or doctor/physician.

P370+P378In case of fire: Use … for extinction.

P405Store locked up.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
148075
Product name
Camphor
Purity
96%
Packaging
100g
Price
$31.4
Updated
2021/03/22
Sigma-Aldrich
Product number
21293
Product name
(−)-Camphor
Purity
analytical standard
Packaging
1 g
Price
$58.6
Updated
2021/03/22
Sigma-Aldrich
Product number
CRM40393
Product name
(±)-Camphor solution
Purity
certified reference material, 2000?μg/mL in methanol, ampule of 1?mL
Packaging
1 mL
Price
$99
Updated
2021/03/22
Sigma-Aldrich
Product number
02070595
Product name
Camphor (dl)
Purity
primary reference standard
Packaging
100mg
Price
$126
Updated
2020/08/18
Sigma-Aldrich
Product number
1087508
Product name
Camphor
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
1 g
Price
$366
Updated
2021/03/22
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Camphor Chemical Properties,Usage,Production

Description

Camphor is a white, waxy organic compound that is incorporated in lotions, ointments, and creams. Camphor is also an active ingredient that is integrated into a majority of over-the-counter medications for cold and cough relief. Camphor oil is obtained from camphor tree wood, where the extract is processed through steam distillation. It has a pungent odor and a strong taste, and it can be absorbed into the skin easily. Currently, synthetic camphor is extracted from turpentine, and it is considered safe for use as long as appropriate indications are upheld.

Uses

Camphor has a wide range of uses based on its anti-inflammatory, anti-fungal, and anti-bacterial properties. It can be used for the treatment of certain skin conditions, enhance respiratory function and as a pain reliever.
Camphor may also be indicated for the treatment of low libido, muscle spasms, anxiety, depression, flatulence, and poor blood circulation, corns, symptoms of heart disease, cold sores, earaches, acne, and hair loss.
Camphor is considered effective for coughs, pain, skin irritation or itching relief, and osteoarthritis. However, there is insufficient evidence that reinforces its effectiveness as a treatment for hemorrhoids, warts, and low blood pressure and as a remedy for insect bites.

Dosage

The topical dose of camphor is 3-11% as an ointment. For skin irritation, itching and pain, 3-11% of the ointment should be applied to the skin 3-4times per day. For coughs and cold relief, a dense layer of 4.7-5.3% of Camphor ointment can be spread evenly onto the chest. For Osteoarthritis, a topical combination comprising 32mg/g of camphor, 50mg/g of chondroitin sulfate, and 30mg/g of glucosamine sulfate can be applied based on one’s requirements for about 8 weeks.
To relieve respiratory congestion through inhalation, 1 tablespoon of Camphor for every quart of water should be placed in a vaporizer 3 times per day. The American Academy of Pediatrics suggests that Camphor should not exceed 11% for topical products and disqualifies the oral use of camphor in children as it may result in toxicity and death.

Interactions

There are no known mild, moderate or severe drug interactions associated with Camphor. However, if a doctor or pharmacist suggests that one can use camphor while on certain medications, then they are aware of potential drug interactions and they could be putting the patient on observation. One should always notify their doctor or pharmacist if they have health concerns or questions related to camphor.

Side Effects

Common side effects associated with Camphor include skin irritation and redness, burning sensation in the throat and mouth, vomiting, nausea, Lip dryness, rashes, eczema, seizures, respiratory issues, toxicity, scalp issues and chest problems.
In pregnant or lactating mothers, camphor may result in physical and neurological damage to the developing fetus as it can be absorbed through the placenta. It can also be absorbed through the skin hence it can contaminate milk in lactating women. Camphor is considered exceptionally harmful for people with Parkinson’s disease as it interacts negatively with medications for Parkinson and it can result in high toxicity levels.

Warning

Cinnamomum camphora, Lodine and cemphire should not be prescribed to a person who is allergic to camphor or its constituent ingredients.
Camphor is safe when used appropriately hence one should confirm that its composition in camphor products does not exceed 11%. A skin patch test is highly recommended before application of camphor products onto the skin.
Camphor products should not be applied onto injured or broken skin as toxic levels of the product may be absorbed into the body. Camphor may also induce respiratory issues such as wheezing when inhaled.

Chemical Properties

Both optical isomers are found widely in nature, with (+)-camphor being the more abundant. It is, for example, the main component of oils obtained from the camphor tree C. camphora. Camphor is produced by fractional distillation and crystallization of camphor oil or, synthetically, by dehydrogenation of isoborneol over a copper catalyst.
Due to its characteristic penetrating, slightly minty odor, camphor is only used in perfuming industrial products. It is far more important as a plasticizer.

Chemical Properties

Camphor, C1oH160, also known as d-2-camphanone, Japan camphor, laurel camphor,Formosa camphor,and gumcamphor,is a terpene ketone. It is colourless solid with a characteristic odour that is obtained from the wood and bark of the camphor tree and is soluble in water and alcohol. It has two optically active forms (dextro and levo) and an optically inactive mixture (racemic) of these two forms. Camphor is used in pharmaceuticals,in disinfectants, in explosives,and to harden nitrocellulose plastics.

Chemical Properties

Camphor is a colorless glassy solid. Penetrating, characteristic odor.

Physical properties

Colorless to white, flammable granules, crystals or waxy semi-solid with a strong, penetrating, fragrant or aromatic odor. Odor threshold concentration is 0.27 ppm (quoted, Amoore and Hautala, 1983).

Uses

dl-Camphor is used as a plasticizer for celluloseesters and ethers; in the manufacture ofplastics and cymene; in cosmetics, lacquers,medicine, explosives, and pyrotechnics; andas a moth repellent.

Uses

Antipruritic.

Uses

camphor (Cinnamomum camphora) is credited with anesthetic, antiinflammatory, antiseptic, astringent, cooling, and refreshing properties, and thought to be slightly stimulating to blood circulation and function. once absorbed by the subcutaneous tissue, it combines in the body with glucoronic acid and is released through the urine. Camphor is effective for oily and acne skin treatment, and has a scent similar to eucalyptus. In high concentrations, it can be an irritant and numb the peripheral sensory nerves. natural camphor is derived from an evergreen tree indigenous to Asia, although now its synthetic substitute is often used.

Definition

A ketone occurring naturally in the wood of the cam- phor tree (Cinnamomum camphora).

Definition

A naturally- occurring white organic compound with a characteristic penetrating odor. It is a cyclic compound and a ketone, formerly obtained from the wood of the camphor tree but now made synthetically. Camphor is used as a platicizer for celluloid and as an insecticide against clothes moths.

Definition

camphor: A white crystalline cyclicketone, C10H16O; r.d. 0.99; m.p.179°C; b.p. 204°C. It was formerly obtainedfrom the wood of the Formosancamphor tree, but can now besynthesized. The compound has acharacteristic odour associated withits use in mothballs. It is a plasticizerin celluloid.

Indications

Camphor is a ketone which, when applied in 1% to 3% concentration, has mild antipruritic effects through its anesthetic and counterirritant properties. Counterirritants are substances that, by inducing other sensations such as coolness or warmth, ‘‘crowd out’’ the perception of pain or itch. Camphor is used in various OTC topical analgesic products in concentrations as high as 9%.

brand name

Anbesol;Cresophene;Dasin;Ddd;Endrine;Makatussin;Mentol sedans sulfamidad;Nasello;Resol;Root bark oil;Spirit of camphor;Tcp;Tetesept;Topic.

World Health Organization (WHO)

Camphor, an aromatic crystalline substance with mild local anaesthetic activity, is available in preparations for both external application and inhalation. The use of such preparations has precipitated convulsions in susceptible infants. This has led several regulatory authorities to require the inclusion of appropriate warnings on labelling.

Synthesis Reference(s)

The Journal of Organic Chemistry, 41, p. 3329, 1976 DOI: 10.1021/jo00882a030

General Description

A colorless or white colored crystalline powder with a strong mothball-like odor. About the same density as water. Emits flammable vapors above 150°F. Used to make moth proofings, pharmaceuticals, and flavorings.

Air & Water Reactions

Highly flammable. Slightly soluble in water.

Reactivity Profile

Naphthalene, Camphor, glycerol, or turpentine will react violently with chromic anhydride [Haz. Chem. Data 1967 p. 68].

Hazard

Evolves flammable and explosive vapors when heated. Eye and upper respiratory tract irri- tant, and anosmia. Questionable carcinogen.

Health Hazard

Vapors of camphor can irritate the eyes, nose,and throat. In humans, such irritation may be felt at >3 ppm concentration. Prolongedexposure can cause headache, dizziness, andloss of sense of smell. Ingestion can causeheadache, nausea, vomiting, and diarrhea,and at high dosages can lead to convulsion,dyspnea, and coma. High dosages can beharmful to gastrointestinal tracts, kidney,and brain.
LD50 value, intraperitoneal (mice): 3000mg/kg.

Health Hazard

Fire may produce irritating and/or toxic gases. Contact may cause burns to skin and eyes. Contact with molten substance may cause severe burns to skin and eyes. Runoff from fire control may cause pollution.

Fire Hazard

Flammable/combustible material. May be ignited by friction, heat, sparks or flames. Some may burn rapidly with flare burning effect. Powders, dusts, shavings, borings, turnings or cuttings may explode or burn with explosive violence. Substance may be transported in a molten form at a temperature that may be above its flash point. May re-ignite after fire is extinguished.

Safety Profile

A human poison by ingestion and possibly other routes. An experimental poison by inhalation, subcutaneous, and intraperitoneal routes. A local irritant. Ingestion causes nausea, vomiting, dizziness, excitation, and convulsions. Mutation data reported. Used

Potential Exposure

Camphor, a natural product, is used as a plasticizer for cellulose esters and ethers; it is used in lacquers and varnishes; and in explosives and pyrotechnics formulations. It is used as a moth repellent and as a medicinal.

Carcinogenicity

Camphor was not teratogenic to rats or rabbits when administered orally during the fetal period of organogenesis at doses up to 1000mg/kg body weight (bw)/day or 681mg/kg bw/day, respectively.9 Signs of maternal toxicity included clonic convulsions, reduced motility, and reduced body weight gain in rats and reduced food consumption and body weight gain in rabbits.

Source

Major component in pine oil (quoted, Verschueren, 1983). Also present in a variety of rosemary shoots (330–3,290 ppm) (Soriano-Cano et al., 1993), anise-scented basil leaves (1,785 ppm) (Brophy et al., 1993), Iberian savory leaves (2,660 ppm) (Arrebola et al., 1994), African blue basil shoots (7,000 ppm), Greek sage (160–5,040 ppm), Montane Mountain mint (3,395–3,880 ppm), yarrow leaves (45–1,780 ppm), and coriander (100–1,300 ppm) (Duke, 1992).

Shipping

UN2717 Camphor, synthetic, Hazard Class: 4.1; Labels: 4.1-Flammable solid. UN1130 camphor oil, Hazard Class: 3; Labels: 3-Flammable liquid

Incompatibilities

May form explosive mixture with air. Violent, possibly explosive, reaction with strong oxidizers, especially chromic anhydride, potassium permanganate. May accumulate static electrical charges, and may cause ignition of its vapors.

Waste Disposal

ncineration of a solution in a flammable solven.

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Camphor Suppliers

AbaChemScene
Tel
732-484-9848
Fax
888-484-5008
Email
sales@chemscene.com
Country
United States
ProdList
3989
Advantage
60
Jishui County Yikang Natural Flavor Oil Refinery
Tel
0796-8128936
Fax
0796-8128936
Email
201999698@qq.com
Country
China
ProdList
159
Advantage
58
Jiangxi Xinsen Natural Vegetable Oil Co., Ltd.
Tel
0796-8284836-
Fax
0796-8284836
Email
592432494@qq.com;
Country
China
ProdList
200
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58
Suzhou Nuowo Kang Chemical Co., Ltd.
Tel
;
Fax
0512-68228771
Email
occasion_peter@126.com;occasion_peter@126.com
Country
China
ProdList
31
Advantage
58
Hebei Zhongbei Jiamei Biological Technology Co., Ltd.
Tel
0311-89171450- ;0311-89171450- ;0311-89171450-
Email
3367228949@qq.com;3265217077@qq.com;2168832571@qq.com
Country
China
ProdList
80
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58
Jinan Wald Chemical Co., Ltd.
Tel
0531-88773586-
Fax
053188773586
Email
304264064@qq.com
Country
China
ProdList
145
Advantage
58
PCL - Business, Laboratory Pharmaceutical
Tel
Fax
QQ:3008022628
Email
Hu.xinyue@purechemland.com
Country
China
ProdList
3571
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58
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
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jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96500
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76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
21-61259100-
Fax
86-21-61259102
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sh@meryer.com
Country
China
ProdList
40264
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62
Alfa Aesar
Tel
400-610-6006; 021-67582000
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30159
Advantage
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View Lastest Price from Camphor manufacturers

Wuhan wingroup Pharmaceutical Co., Ltd
Product
Camphor 76-22-2
Price
US $10.00/KG
Min. Order
100g
Purity
99%
Supply Ability
1000MT/Month
Release date
2021-07-08
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Camphor 76-22-2
Price
US $0.00/KG
Min. Order
1KG
Purity
96%min,USP/BP
Supply Ability
10tons/month
Release date
2021-06-19
Hebei Crovell Biotech Co Ltd
Product
Camphor 76-22-2
Price
US $10.70/Kg/Drum
Min. Order
10g
Purity
99%
Supply Ability
10000kg
Release date
2021-06-29

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