MLS-573151

Product Name: MLS-573151
CAS No.: 10179-57-4
Chemical Name: MLS-573151
Synonyms: MLS-573151;4-(3,5-Diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide;4-(4,5-dihydro-3,5-diphenyl-1H-pyrazol-1-yl)-benzenesulfonamide;Benzenesulfonamide, 4-(4,5-dihydro-3,5-diphenyl-1H-pyrazol-1-yl)-;MLS-573151,granulocytes,Inhibitor,Ras,inhibit,MLS-000573151,MLS 000573151,GTPase,MLS 573151,Cdc42,MLS573151,MLS000573151
CBNumber: CB03152689
Molecular Formula: C21H19N3O2S
Formula Weight: 377.46
MOL File: 10179-57-4.mol

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MLS-573151 Property

storage temp.: RT
solubility: Soluble in DMSO (up to 20 mg/ml).
form: solid
color: Yellow
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 15269
Product name: MLS-573151
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 15269
Product name: MLS-573151
Purity: ≥98%
Packaging: 5mg
Price: $117
Updated: 2024/03/01

Cayman Chemical

Product number: 15269
Product name: MLS-573151
Purity: ≥98%
Packaging: 10mg
Price: $201
Updated: 2024/03/01

Cayman Chemical

Product number: 15269
Product name: MLS-573151
Purity: ≥98%
Packaging: 25mg
Price: $426
Updated: 2024/03/01

ChemScene

Product number: CS-0062951
Product name: MLS-573151
Purity: 99.74%
Packaging: 5mg
Price: $100
Updated: 2021/12/16

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MLS-573151 Chemical Properties,Usage,Production

Description

The Rho family of GTPases regulates diverse signal transduction pathways. One member, the cell division control protein 42 homolog (Cdc42), is involved in filopodia function, cell polarity, cell cycling, and other processes. MLS-573151 is a specific, cell permeable inhibitor of Cdc42 (IC₅₀ = 2 μM). It has no effect on other GTPases, including the related Rho family members RhoA, Rac1, and Rac2. It acts by blocking the binding of GTP to Cdc42.

Uses

The Rho family of GTPases regulates diverse signal transduction pathways. One member, the cell division control protein 42 homolog (Cdc42), is involved in filopodia function, cell polarity, cell cycling, and other processes. MLS-573151 is a specific, cell permeable inhibitor of Cdc42 (IC50 = 2 μM). It has no effect on other GTPases, including the related Rho family members RhoA, Rac1, and Rac2. It acts by blocking the binding of GTP to Cdc42.[Cayman Chemical]

in vitro

mls-573151 was a specific, cell permeable inhibitor of cdc42 with an ic50 of 2 μm [1]. mls-573151 showed no effect on other gtpases, including the related rho family members rhoa, rac1, and rac2. mls-573151 functioned by blocking the binding of gtp to cdc42 [1]. in marrow-derived mesenchymal stem cells, mls-573151 showed no effect on cell migration [3].

References

1) Surviladze et al. (2010), Identification of a small GTPase inhibitor using a high-throughput flow cytometry bead-based multiplex assay; J. Biomol. Screening, 15 10 2) Wang et al. (2017), Cannabinoid Receptor 1 Mediates Homing of Bone Marrow-Derived Mesenchymal Stem Cells Triggered by Chronic Liver Injury; J. Cell Physiol., 232 110

MLS-573151 Preparation Products And Raw materials

Raw materials

Preparation Products

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MLS-573151 Suppliers

China 50 Ukraine 1 United States 8 Global 59

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 4553
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Shanghai Chaolan Chemical Technology Center

Tel: QQ:65489617 15618227136
Fax: 21-5161 9052
Email: info@SuperLan-chem.com
Country: China
ProdList: 6527
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32063
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Shanghai Dongyang Biotechnology Co., Ltd.

Tel: 0512-0512-13601744364 13601744364
Email: chemsharker@126.com
Country: China
ProdList: 917
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11217
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 62163
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InvivoChem

Tel: 13549236410
Email: sales@invivochem.cn
Country: China
ProdList: 6753
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24648
Advantage: 58

10179-57-4, MLS-573151Related Search:

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MLS-573151

Benzenesulfonamide, 4-(4,5-dihydro-3,5-diphenyl-1H-pyrazol-1-yl)-

4-(3,5-Diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide

MLS-573151,granulocytes,Inhibitor,Ras,inhibit,MLS-000573151,MLS 000573151,GTPase,MLS 573151,Cdc42,MLS573151,MLS000573151

4-(4,5-dihydro-3,5-diphenyl-1H-pyrazol-1-yl)-benzenesulfonamide

10179-57-4